PO2F3_MOUSE
ID PO2F3_MOUSE Reviewed; 431 AA.
AC P31362;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 25-MAY-2022, entry version 160.
DE RecName: Full=POU domain, class 2, transcription factor 3;
DE AltName: Full=Epoc-1;
DE AltName: Full=Octamer-binding protein 11;
DE Short=Oct-11;
DE AltName: Full=Octamer-binding transcription factor 11;
DE Short=OTF-11;
GN Name=Pou2f3; Synonyms=Epoc1, Oct11, Otf-11, Otf11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Thymus;
RX PubMed=8441607; DOI=10.1093/nar/21.1.127;
RA Goldsborough A.S., Healy L.E., Copeland N.G., Gilbert D.J., Jenkins N.A.,
RA Willison K.R., Ashworth A.;
RT "Cloning, chromosomal localization and expression pattern of the POU domain
RT gene Oct-11.";
RL Nucleic Acids Res. 21:127-134(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Thymus;
RX PubMed=8224904; DOI=10.1016/0378-1119(93)90634-f;
RA Yukawa K., Yasui T., Yamamoto A., Shiku H., Kishimoto T., Kikutani H.;
RT "Epoc-1: a POU-domain gene expressed in murine epidermal basal cells and
RT thymic stromal cells.";
RL Gene 133:163-169(1993).
CC -!- FUNCTION: Transcription factor that binds to the octamer motif (5'-
CC ATTTGCAT-3').
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Skin, thymus, stomach and testis.
CC -!- DEVELOPMENTAL STAGE: During embryogenesis and in adults.
CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-2
CC subfamily. {ECO:0000305}.
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DR EMBL; Z18537; CAA79222.1; -; mRNA.
DR EMBL; L14677; AAA16855.1; -; mRNA.
DR CCDS; CCDS40596.1; -.
DR PIR; S35541; S35541.
DR AlphaFoldDB; P31362; -.
DR SMR; P31362; -.
DR STRING; 10090.ENSMUSP00000135115; -.
DR iPTMnet; P31362; -.
DR PhosphoSitePlus; P31362; -.
DR MaxQB; P31362; -.
DR PaxDb; P31362; -.
DR PRIDE; P31362; -.
DR ProteomicsDB; 289469; -.
DR MGI; MGI:102565; Pou2f3.
DR eggNOG; KOG3802; Eukaryota.
DR InParanoid; P31362; -.
DR PhylomeDB; P31362; -.
DR ChiTaRS; Pou2f3; mouse.
DR PRO; PR:P31362; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P31362; protein.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016604; C:nuclear body; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0005667; C:transcription regulator complex; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0008544; P:epidermis development; IGI:MGI.
DR GO; GO:0030216; P:keratinocyte differentiation; IGI:MGI.
DR GO; GO:0043922; P:negative regulation by host of viral transcription; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0042060; P:wound healing; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013847; POU.
DR InterPro; IPR000327; POU_dom.
DR InterPro; IPR000972; TF_octamer.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 1.
DR PRINTS; PR00029; OCTAMER.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00035; POU_1; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..431
FT /note="POU domain, class 2, transcription factor 3"
FT /id="PRO_0000100718"
FT DOMAIN 176..250
FT /note="POU-specific"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT DNA_BIND 274..333
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 139
FT /note="R -> A (in Ref. 1; CAA79222)"
FT /evidence="ECO:0000305"
FT CONFLICT 249
FT /note="P -> A (in Ref. 1; CAA79222)"
FT /evidence="ECO:0000305"
FT CONFLICT 396..431
FT /note="PTASQNNSKAAMNSSSSSSFNSSGSWYRWNHPTYLH -> SQVWALLT (in
FT Ref. 1; CAA79222)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 431 AA; 47071 MW; 7E283E797EA8D3FA CRC64;
MVNLEPMHTE IKMSGDVADS TDTRSTFGQV EPGNDRNGLD FNRQIKTEDL GDSLQQTLSH
RPCHLSQGPT MMPGNQMSGD MASLHPLQQL VLVPGHLQSV SQFLLSQTPP GQQGLQPNLL
SFPQQQSTLL LPQTGPGLRS QAVGRPGLSG SSLEPHLDAP QHLPGPKHLP GPGGNDEPTD
LEELEKFAKT FKQRRIKLGF TQGDVGLAMG KLYGNDFSQT TISRFEALNL SFKNMCKLKP
LLEKWLNDPE SSPSDPSAST PSSYPTLSEV FGRKRKKRTS IETNIRLTLE KRFQDNPKPS
SEEISMIAEQ LSMEKEVVRV WFCNRRQKEK RINCPVATPV KPPIYNSRLV SPSGSLGPLS
VPPVHSTMPG TVTSSCSPGN NSRPSSPGSG LHASSPTASQ NNSKAAMNSS SSSSFNSSGS
WYRWNHPTYL H
