PO2F3_RAT
ID PO2F3_RAT Reviewed; 430 AA.
AC P42571; P42572;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 25-MAY-2022, entry version 150.
DE RecName: Full=POU domain, class 2, transcription factor 3;
DE AltName: Full=Octamer-binding protein 11;
DE Short=Oct-11;
DE AltName: Full=Octamer-binding transcription factor 11;
DE Short=OTF-11;
DE AltName: Full=Transcription factor Skn-1;
GN Name=Pou2f3; Synonyms=Otf11, Skn-1, Skn1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Fischer; TISSUE=Skin;
RX PubMed=7682011; DOI=10.1126/science.7682011;
RA Andersen B., Schonemann M.D., Flynn S.E., Pearse R.V. II, Singh H.,
RA Rosenfeld M.G.;
RT "Skn-1a and Skn-1i: two functionally distinct Oct-2-related factors
RT expressed in epidermis.";
RL Science 260:78-82(1993).
RN [2]
RP ERRATUM OF PUBMED:7682011.
RX PubMed=8248794;
RA Andersen B., Schonemann M.D., Flynn S.E., Pearse R.V. II, Singh H.,
RA Rosenfeld M.G.;
RL Science 262:1499-1499(1993).
CC -!- FUNCTION: Transcription factor that binds to the octamer motif (5'-
CC ATTTGCAT-3'). Activates cytokeratin 10 (K10) gene expression. May serve
CC a regulatory function with respect to epidermal development. Isoform 2
CC inhibits transactivation by OCT-1.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=Skn-1a;
CC IsoId=P42571-1; Sequence=Displayed;
CC Name=2; Synonyms=Skn-1i;
CC IsoId=P42571-2; Sequence=VSP_002332;
CC -!- TISSUE SPECIFICITY: Expressed in epidermis.
CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-2
CC subfamily. {ECO:0000305}.
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DR EMBL; L23862; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; L23863; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; A46216; A46216.
DR AlphaFoldDB; P42571; -.
DR SMR; P42571; -.
DR STRING; 10116.ENSRNOP00000012170; -.
DR PaxDb; P42571; -.
DR UCSC; RGD:621691; rat. [P42571-1]
DR RGD; 621691; Pou2f3.
DR eggNOG; KOG3802; Eukaryota.
DR InParanoid; P42571; -.
DR PhylomeDB; P42571; -.
DR PRO; PR:P42571; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0005667; C:transcription regulator complex; ISO:RGD.
DR GO; GO:0003677; F:DNA binding; ISO:RGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0008544; P:epidermis development; IDA:RGD.
DR GO; GO:0030216; P:keratinocyte differentiation; ISO:RGD.
DR GO; GO:0043922; P:negative regulation by host of viral transcription; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:RGD.
DR GO; GO:0042060; P:wound healing; ISO:RGD.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013847; POU.
DR InterPro; IPR000327; POU_dom.
DR InterPro; IPR000972; TF_octamer.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 1.
DR PRINTS; PR00029; OCTAMER.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00035; POU_1; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..430
FT /note="POU domain, class 2, transcription factor 3"
FT /id="PRO_0000100719"
FT DOMAIN 176..250
FT /note="POU-specific"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT DNA_BIND 274..333
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 129..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..113
FT /note="MVNLEPMHTEIKMSGDVADSTDARSTFGQVESGNDRNGLDFNRQIKTEDLGD
FT TLHESLSHRPCHLTEGPTMMPGNQMSGDMASLHPLQQLVLVPGHLQSVSQFLLSQTPPG
FT QQ -> MVSMFSLSFKWPGFCLFVCLFLCPFVLPCHS (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_002332"
SQ SEQUENCE 430 AA; 46814 MW; 9B538CBD9743B96F CRC64;
MVNLEPMHTE IKMSGDVADS TDARSTFGQV ESGNDRNGLD FNRQIKTEDL GDTLHESLSH
RPCHLTEGPT MMPGNQMSGD MASLHPLQQL VLVPGHLQSV SQFLLSQTPP GQQGLQPNLL
SFPQQQSTLL LPQTGPGLTS QAVGRPGLSG SSLEPHLEAS QHLPGPKHLP GPGGNDEPTD
LEELEKFAKT FKQRRIKLGF TQGDVGLAMG KLYGNDFSQT TISRFEALNL SFKNMCKLKP
LLEKWLNDAE SSPADPSAST PSSYPTLSEV FGRKRKKRTS IETNIRLTLE KRFQDNPKPS
SEEISMIAEQ LSMEKEVVRV WFCNRRQKEK RINCPVATPV KPPIYNSRLV SPSGSLGSLS
VPPVHSTMPG TVTSSCSPGN NSRPSSPGSG LHASSPTASQ NNSKAAMNPS SAAFNSSGSW
YRWNHPAYLH
