ID   PO2F3_XENLA             Reviewed;         111 AA.
AC   P20912;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=POU domain, class 2, transcription factor 3;
DE   AltName: Full=Homeotic protein NRL-16;
DE            Short=XlNRL-16;
DE   AltName: Full=Homeotic protein NRL-21;
DE            Short=XlNRL-21;
DE   Flags: Fragment;
GN   Name=pou2f3; Synonyms=nrl-16, nrl-21;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Neurula;
RX   PubMed=2235499; DOI=10.1093/nar/18.20.6131;
RA   Baltzinger M., Stiegler P., Remy P.;
RT   "Cloning and sequencing of POU-boxes expressed in Xenopus laevis neurula
RT   embryos.";
RL   Nucleic Acids Res. 18:6131-6131(1990).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the POU transcription factor family. Class-2
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X54678; CAA38492.1; -; mRNA.
DR   PIR; S12179; S12179.
DR   AlphaFoldDB; P20912; -.
DR   SMR; P20912; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR013847; POU.
DR   InterPro; IPR000327; POU_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00157; Pou; 1.
DR   PRINTS; PR00028; POUDOMAIN.
DR   SMART; SM00352; POU; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00465; POU_2; 1.
DR   PROSITE; PS51179; POU_3; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           <1..>111
FT                   /note="POU domain, class 2, transcription factor 3"
FT                   /id="PRO_0000100766"
FT   DOMAIN          <1..49
FT                   /note="POU-specific"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT   DNA_BIND        73..>111
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   NON_TER         1
FT   NON_TER         111
SQ   SEQUENCE   111 AA;  12530 MW;  F0F4899E700E6B51 CRC64;
     QGDVGLAMGK LYGNDFSQTT ISRFEALNLS FKNMCKLKPL LEKWLNDAES APSDTALTPS
     ANYAQLSEMF GRKRKKRTSI ETNIRLTLEK RFQDNPKPSS EEISMIAEQL V