ID   PO3F3_PIG               Reviewed;         131 AA.
AC   Q29087;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=POU domain, class 3, transcription factor 3;
DE   AltName: Full=Brain-specific homeobox/POU domain protein 1;
DE            Short=Brain-1;
DE            Short=Brn-1;
DE   Flags: Fragment;
GN   Name=POU3F3; Synonyms=BRN1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hypothalamus;
RA   Woollard J., Schmitz C.B., Tuggle C.K.;
RL   Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that acts synergistically with SOX11 and
CC       SOX4. Plays a role in neuronal development. Is implicated in an
CC       enhancer activity at the embryonic met-mesencephalic junction; the
CC       enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By
CC       similarity). {ECO:0000250|UniProtKB:P31361,
CC       ECO:0000250|UniProtKB:Q63262}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P20264}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC       ECO:0000255|PROSITE-ProRule:PRU00530}.
CC   -!- TISSUE SPECIFICITY: Brain.
CC   -!- SIMILARITY: Belongs to the POU transcription factor family. Class-3
CC       subfamily. {ECO:0000305}.
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DR   EMBL; L28764; AAA31106.1; -; mRNA.
DR   AlphaFoldDB; Q29087; -.
DR   SMR; Q29087; -.
DR   STRING; 9823.ENSSSCP00000026394; -.
DR   PaxDb; Q29087; -.
DR   PRIDE; Q29087; -.
DR   eggNOG; KOG3802; Eukaryota.
DR   InParanoid; Q29087; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0072218; P:metanephric ascending thin limb development; ISS:UniProtKB.
DR   GO; GO:0072240; P:metanephric DCT cell differentiation; ISS:UniProtKB.
DR   GO; GO:0072236; P:metanephric loop of Henle development; ISS:UniProtKB.
DR   GO; GO:0072227; P:metanephric macula densa development; ISS:UniProtKB.
DR   GO; GO:0072233; P:metanephric thick ascending limb development; ISS:UniProtKB.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR013847; POU.
DR   InterPro; IPR000327; POU_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00157; Pou; 1.
DR   PRINTS; PR00028; POUDOMAIN.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00352; POU; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00035; POU_1; 1.
DR   PROSITE; PS00465; POU_2; 1.
DR   PROSITE; PS51179; POU_3; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Neurogenesis; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           <1..>131
FT                   /note="POU domain, class 3, transcription factor 3"
FT                   /id="PRO_0000100729"
FT   DOMAIN          <1..60
FT                   /note="POU-specific"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT   DNA_BIND        78..>131
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   NON_TER         1
FT   NON_TER         131
SQ   SEQUENCE   131 AA;  14724 MW;  ECD06A9A857B7127 CRC64;
     FTQRRMKLGF TQADVGLALG TLYGNVFSQT TICRFEALQL SFKNMCKLKP LLNKWLEEAD
     SSTGSPTSID KIAAQGRKRK KRTSIEVSVK GALESHFLKC PKPSAQEITN LADSLQLEKE
     VVRVWFCNNL Q