PO3F4_MOUSE
ID PO3F4_MOUSE Reviewed; 361 AA.
AC P62515; P25216;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=POU domain, class 3, transcription factor 4;
DE AltName: Full=Brain-specific homeobox/POU domain protein 4;
DE Short=Brain-4;
DE Short=Brn-4;
DE AltName: Full=Octamer-binding protein 9;
DE Short=Oct-9;
DE AltName: Full=Octamer-binding transcription factor 9;
DE Short=OTF-9;
GN Name=Pou3f4; Synonyms=Brn-4, Brn4, Otf9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1565620; DOI=10.1073/pnas.89.8.3280;
RA Hara Y., Rovescalli C., Kim Y., Nirenberg M.;
RT "Structure and evolution of four POU domain genes expressed in mouse
RT brain.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:3280-3284(1992).
CC -!- FUNCTION: Probable transcription factor which exert its primary action
CC widely during early neural development and in a very limited set of
CC neurons in the mature brain.
CC -!- SUBUNIT: Interacts with HNRNPU. {ECO:0000250|UniProtKB:P49335}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Brain specific.
CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-3
CC subfamily. {ECO:0000305}.
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DR EMBL; M88301; AAA39962.1; -; Genomic_DNA.
DR CCDS; CCDS30355.1; -.
DR PIR; S31225; S31225.
DR RefSeq; NP_032927.1; NM_008901.2.
DR AlphaFoldDB; P62515; -.
DR SMR; P62515; -.
DR BioGRID; 202308; 1.
DR IntAct; P62515; 1.
DR STRING; 10090.ENSMUSP00000077354; -.
DR iPTMnet; P62515; -.
DR PhosphoSitePlus; P62515; -.
DR MaxQB; P62515; -.
DR PaxDb; P62515; -.
DR PRIDE; P62515; -.
DR ProteomicsDB; 289470; -.
DR Antibodypedia; 14273; 92 antibodies from 21 providers.
DR DNASU; 18994; -.
DR Ensembl; ENSMUST00000078229; ENSMUSP00000077354; ENSMUSG00000056854.
DR GeneID; 18994; -.
DR KEGG; mmu:18994; -.
DR UCSC; uc009ucv.1; mouse.
DR CTD; 5456; -.
DR MGI; MGI:101894; Pou3f4.
DR VEuPathDB; HostDB:ENSMUSG00000056854; -.
DR eggNOG; KOG3802; Eukaryota.
DR GeneTree; ENSGT00940000161429; -.
DR HOGENOM; CLU_013065_1_2_1; -.
DR InParanoid; P62515; -.
DR OMA; HNNHGSH; -.
DR OrthoDB; 752252at2759; -.
DR PhylomeDB; P62515; -.
DR TreeFam; TF316413; -.
DR BioGRID-ORCS; 18994; 2 hits in 71 CRISPR screens.
DR PRO; PR:P62515; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; P62515; protein.
DR Bgee; ENSMUSG00000056854; Expressed in rostral migratory stream and 86 other tissues.
DR ExpressionAtlas; P62515; baseline and differential.
DR Genevisible; P62515; MM.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; ISO:MGI.
DR GO; GO:0003680; F:minor groove of adenine-thymine-rich DNA binding; ISO:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0090103; P:cochlea morphogenesis; IGI:UniProtKB.
DR GO; GO:0021879; P:forebrain neuron differentiation; IMP:MGI.
DR GO; GO:0048839; P:inner ear development; IMP:MGI.
DR GO; GO:2001054; P:negative regulation of mesenchymal cell apoptotic process; IGI:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007605; P:sensory perception of sound; IMP:MGI.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISO:MGI.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013847; POU.
DR InterPro; IPR000327; POU_dom.
DR InterPro; IPR016362; TF_POU_3.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 1.
DR PIRSF; PIRSF002629; Transcription_factor_POU; 1.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00035; POU_1; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..361
FT /note="POU domain, class 3, transcription factor 4"
FT /id="PRO_0000100734"
FT DOMAIN 186..260
FT /note="POU-specific"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT DNA_BIND 278..337
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 99..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 265
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P20265"
SQ SEQUENCE 361 AA; 39417 MW; EA1D32DAA168D0BF CRC64;
MATAASNPYS ILSSSSLVHA DSAGMQQGSP FRNPQKLLQS DYLQGVPSNG HPLGHHWVTS
LSDGGPWSST LATSPLDQQD VKPGREDLQL GAIIHHRSPH VAHHSPHTNH PNAWGASPAP
NSSITSSGQP LNVYSQPGFT VSGMLEHGGL TPPPAAASTQ SLHPVLREPP DHGELGSHHC
QDHSDEETPT SDELEQFAKQ FKQRRIKLGF TQADVGLALG TLYGNVFSQT TICRFEALQL
SFKNMCKLKP LLNKWLEEAD SSTGSPTSID KIAAQGRKRK KRTSIEVSVK GVLETHFLKC
PKPAAQEISS LADSLQLEKE VVRVWFCNRR QKEKRMTPPG DQQPHEVYSH TVKTDASCHD
L
