PO3F4_RAT
ID PO3F4_RAT Reviewed; 361 AA.
AC P62516; P25216;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=POU domain, class 3, transcription factor 4;
DE AltName: Full=Brain-specific homeobox/POU domain protein 4;
DE Short=Brain-4;
DE Short=Brn-4;
DE AltName: Full=Octamer-binding protein 9;
DE Short=Oct-9;
DE AltName: Full=Octamer-binding transcription factor 9;
DE Short=OTF-9;
DE AltName: Full=RHS2 class III POU protein;
GN Name=Pou3f4; Synonyms=Brn-4, Brn4, Otf9;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=1628619; DOI=10.1002/j.1460-2075.1992.tb05320.x;
RA Mathis J.M., Simmons D.M., He X., Swanson L.W., Rosenfeld M.G.;
RT "Brain 4: a novel mammalian POU domain transcription factor exhibiting
RT restricted brain-specific expression.";
RL EMBO J. 11:2551-2561(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1348858; DOI=10.1073/pnas.89.8.3285;
RA le Moine C., Young W.S.;
RT "RHS2, a POU domain-containing gene, and its expression in developing and
RT adult rat.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:3285-3289(1992).
CC -!- FUNCTION: Probable transcription factor which exert its primary action
CC widely during early neural development and in a very limited set of
CC neurons in the mature brain.
CC -!- SUBUNIT: Interacts with HNRNPU. {ECO:0000250|UniProtKB:P49335}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Brain specific.
CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-3
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z11834; CAA77855.1; -; mRNA.
DR EMBL; M84645; AAA42042.1; -; mRNA.
DR PIR; A44144; A44144.
DR RefSeq; NP_058948.1; NM_017252.2.
DR AlphaFoldDB; P62516; -.
DR SMR; P62516; -.
DR BioGRID; 248222; 5.
DR STRING; 10116.ENSRNOP00000003724; -.
DR iPTMnet; P62516; -.
DR PhosphoSitePlus; P62516; -.
DR PaxDb; P62516; -.
DR Ensembl; ENSRNOT00000003724; ENSRNOP00000003724; ENSRNOG00000002784.
DR GeneID; 29589; -.
DR KEGG; rno:29589; -.
DR UCSC; RGD:61947; rat.
DR CTD; 5456; -.
DR RGD; 61947; Pou3f4.
DR eggNOG; KOG3802; Eukaryota.
DR GeneTree; ENSGT00940000161429; -.
DR HOGENOM; CLU_013065_1_2_1; -.
DR InParanoid; P62516; -.
DR OMA; HNNHGSH; -.
DR OrthoDB; 752252at2759; -.
DR PhylomeDB; P62516; -.
DR TreeFam; TF316413; -.
DR PRO; PR:P62516; -.
DR Proteomes; UP000002494; Chromosome X.
DR Bgee; ENSRNOG00000002784; Expressed in frontal cortex and 1 other tissue.
DR Genevisible; P62516; RN.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0003690; F:double-stranded DNA binding; IDA:RGD.
DR GO; GO:0003680; F:minor groove of adenine-thymine-rich DNA binding; IDA:RGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0090103; P:cochlea morphogenesis; ISS:UniProtKB.
DR GO; GO:0021879; P:forebrain neuron differentiation; ISO:RGD.
DR GO; GO:0048839; P:inner ear development; ISO:RGD.
DR GO; GO:2001054; P:negative regulation of mesenchymal cell apoptotic process; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007605; P:sensory perception of sound; ISO:RGD.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IDA:RGD.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013847; POU.
DR InterPro; IPR000327; POU_dom.
DR InterPro; IPR016362; TF_POU_3.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 1.
DR PIRSF; PIRSF002629; Transcription_factor_POU; 1.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00035; POU_1; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..361
FT /note="POU domain, class 3, transcription factor 4"
FT /id="PRO_0000100735"
FT DOMAIN 186..260
FT /note="POU-specific"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT DNA_BIND 278..337
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 99..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 265
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P20265"
SQ SEQUENCE 361 AA; 39417 MW; EA1D32DAA168D0BF CRC64;
MATAASNPYS ILSSSSLVHA DSAGMQQGSP FRNPQKLLQS DYLQGVPSNG HPLGHHWVTS
LSDGGPWSST LATSPLDQQD VKPGREDLQL GAIIHHRSPH VAHHSPHTNH PNAWGASPAP
NSSITSSGQP LNVYSQPGFT VSGMLEHGGL TPPPAAASTQ SLHPVLREPP DHGELGSHHC
QDHSDEETPT SDELEQFAKQ FKQRRIKLGF TQADVGLALG TLYGNVFSQT TICRFEALQL
SFKNMCKLKP LLNKWLEEAD SSTGSPTSID KIAAQGRKRK KRTSIEVSVK GVLETHFLKC
PKPAAQEISS LADSLQLEKE VVRVWFCNRR QKEKRMTPPG DQQPHEVYSH TVKTDASCHD
L
