PO4F1_CHICK
ID PO4F1_CHICK Reviewed; 116 AA.
AC P55968;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=POU domain, class 4, transcription factor 1;
DE AltName: Full=Brain-specific homeobox/POU domain protein 3A;
DE Short=Brain-3A;
DE Short=Brn-3A;
DE Flags: Fragment;
GN Name=POU4F1; Synonyms=BRN-3A, BRN3A;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=White leghorn; TISSUE=Spleen;
RX PubMed=9363595; DOI=10.1111/j.1365-2052.1997.00160.x;
RA Heltemes L.M., Tuggle C.K., Lamont S.J.;
RT "Isolation and mapping of two chicken POU family genes and the
RT identification of a syntenic group with human and mouse.";
RL Anim. Genet. 28:346-350(1997).
CC -!- FUNCTION: Multifunctional transcription factor with different regions
CC mediating its different effects. Acts by binding (via its C-terminal
CC domain) to sequences related to the consensus octamer motif 5'-
CC ATGCAAAT-3' in the regulatory regions of its target genes. Regulates
CC the expression of specific genes involved in differentiation and
CC survival within a subset of neuronal lineages. It has been shown that
CC activation of some of these genes requires its N-terminal domain, maybe
CC through a neuronal-specific cofactor. {ECO:0000250|UniProtKB:P17208}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P17208}. Cytoplasm
CC {ECO:0000250|UniProtKB:P17208}.
CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-4
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U77642; AAD03154.1; -; mRNA.
DR AlphaFoldDB; P55968; -.
DR SMR; P55968; -.
DR VEuPathDB; HostDB:geneid_100857623; -.
DR InParanoid; P55968; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0003697; F:single-stranded DNA binding; ISS:UniProtKB.
DR GO; GO:0071345; P:cellular response to cytokine stimulus; ISS:UniProtKB.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; ISS:UniProtKB.
DR GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0045672; P:positive regulation of osteoclast differentiation; ISS:UniProtKB.
DR GO; GO:2000679; P:positive regulation of transcription regulatory region DNA binding; ISS:UniProtKB.
DR GO; GO:0051090; P:regulation of DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013847; POU.
DR InterPro; IPR015584; POU4-TF1.
DR InterPro; IPR000327; POU_dom.
DR PANTHER; PTHR11636:SF42; PTHR11636:SF42; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 1.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN <1..>116
FT /note="POU domain, class 4, transcription factor 1"
FT /id="PRO_0000100739"
FT DOMAIN <1..54
FT /note="POU-specific"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT DNA_BIND 72..>116
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 56..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT NON_TER 116
SQ SEQUENCE 116 AA; 12703 MW; D90A6E4C63CD12C9 CRC64;
VTQADVGSAL ANLKIPGVGS LSQSTICRFE SLTLSHNNMI ALKPILQAWL EEAEGAQREK
MNKPELFNGG EKKRKRTSIA APEKRSLEAY FAVQPRPSSE KIAAIAEKLD LKKNVV
