PO4F3_RAT
ID PO4F3_RAT Reviewed; 338 AA.
AC D3ZTL1;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=POU domain, class 4, transcription factor 3;
GN Name=Pou4f3 {ECO:0000312|RGD:1310459};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RX PubMed=8637595; DOI=10.1038/381603a0;
RA Erkman L., McEvilly R.J., Luo L., Ryan A.K., Hooshmand F., O'Connell S.M.,
RA Keithley E.M., Rapaport D.H., Ryan A.F., Rosenfeld M.G.;
RT "Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual
RT system development.";
RL Nature 381:603-606(1996).
CC -!- FUNCTION: Acts as a transcriptional activator. Acts by binding to
CC sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the
CC regulatory regions of its target genes. Involved in the auditory system
CC development, required for terminal differentiation of hair cells in the
CC inner ear. {ECO:0000250|UniProtKB:Q63955}.
CC -!- SUBUNIT: Interacts with ISL1. {ECO:0000250|UniProtKB:Q63955}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15319}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q15319}. Note=Preferentially localized in the
CC nucleus. {ECO:0000250|UniProtKB:Q15319}.
CC -!- TISSUE SPECIFICITY: Expressed in the chochlea of the inner ear.
CC {ECO:0000269|PubMed:8637595}.
CC -!- DEVELOPMENTAL STAGE: At E14, strongly expressed in cochlear and
CC vestibular hair cells of the inner ear, in the cochlea at E18 and
CC coninues to the adulthood. {ECO:0000269|PubMed:8637595}.
CC -!- SIMILARITY: Belongs to the POU transcription factor family.
CC {ECO:0000255, ECO:0000255|RuleBase:RU361194}.
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DR EMBL; AABR07031849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH473974; EDL76485.1; -; Genomic_DNA.
DR RefSeq; NP_001102359.1; NM_001108889.1.
DR AlphaFoldDB; D3ZTL1; -.
DR SMR; D3ZTL1; -.
DR STRING; 10116.ENSRNOP00000025465; -.
DR PaxDb; D3ZTL1; -.
DR PRIDE; D3ZTL1; -.
DR Ensembl; ENSRNOT00000025465; ENSRNOP00000025465; ENSRNOG00000018842.
DR GeneID; 364855; -.
DR KEGG; rno:364855; -.
DR UCSC; RGD:1310459; rat.
DR CTD; 5459; -.
DR RGD; 1310459; Pou4f3.
DR eggNOG; KOG1168; Eukaryota.
DR GeneTree; ENSGT00940000160880; -.
DR HOGENOM; CLU_013065_0_0_1; -.
DR InParanoid; D3ZTL1; -.
DR OMA; MKYSAAH; -.
DR OrthoDB; 929123at2759; -.
DR PhylomeDB; D3ZTL1; -.
DR TreeFam; TF316413; -.
DR PRO; PR:D3ZTL1; -.
DR Proteomes; UP000002494; Chromosome 18.
DR Proteomes; UP000234681; Chromosome 18.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0048675; P:axon extension; ISO:RGD.
DR GO; GO:0042491; P:inner ear auditory receptor cell differentiation; ISO:RGD.
DR GO; GO:0048839; P:inner ear development; ISO:RGD.
DR GO; GO:0042472; P:inner ear morphogenesis; ISO:RGD.
DR GO; GO:0060113; P:inner ear receptor cell differentiation; ISO:RGD.
DR GO; GO:0050885; P:neuromuscular process controlling balance; ISO:RGD.
DR GO; GO:0051402; P:neuron apoptotic process; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0031290; P:retinal ganglion cell axon guidance; ISO:RGD.
DR GO; GO:0007605; P:sensory perception of sound; ISO:RGD.
DR GO; GO:0021562; P:vestibulocochlear nerve development; ISO:RGD.
DR CDD; cd00086; homeodomain; 1.
DR CDD; cd00093; HTH_XRE; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013847; POU.
DR InterPro; IPR032961; POU4F3.
DR InterPro; IPR000327; POU_dom.
DR PANTHER; PTHR11636:SF43; PTHR11636:SF43; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 1.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00035; POU_1; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 2: Evidence at transcript level;
KW Activator; Cytoplasm; Differentiation; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..338
FT /note="POU domain, class 4, transcription factor 3"
FT /id="PRO_0000438270"
FT DOMAIN 179..256
FT /note="POU-specific"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT DNA_BIND 274..333
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 91..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 56..65
FT /note="POU-IV box"
FT /evidence="ECO:0000250|UniProtKB:Q15319"
SQ SEQUENCE 338 AA; 37043 MW; 35059F2307DF4C4B CRC64;
MMAMNAKQPF GMHPVLQEPK FSSLHSGSEA MRRVCLPAPQ LQGNIFGSFD ESLLARAEAL
AAVDIVSHGK NHPFKPDATY HTMSSVPCTS TSPTVPISHP AALTSHPHHP VHQGLEGDLL
EHISPTLSVS GLGAPEHSVM PAQIHPHHLG AMGHLHQAMG MSHPHAVAPH SAMPACLSDV
ESDPRELEAF AERFKQRRIK LGVTQADVGA ALANLKIPGV GSLSQSTICR FESLTLSHNN
MIALKPVLQA WLEEAEAAYR EKNSKPELFN GSERKRKRTS IAAPEKRSLE AYFAIQPRPS
SEKIAAIAEK LDLKKNVVRV WFCNQRQKQK RMKYSAVH
