ID   PO6F1_DANRE             Reviewed;         610 AA.
AC   P31367; B3DFR1;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=POU domain, class 6, transcription factor 1;
DE   AltName: Full=POU domain protein C;
DE            Short=POU[C];
DE            Short=ZfPOU[C];
GN   Name=pou6f1; Synonyms=pou[c], pouc;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   STRAIN=NC-1; TISSUE=Embryonic liver;
RX   PubMed=8441661; DOI=10.1093/nar/21.3.475;
RA   Johansen T., Moens U., Holm T., Fjose A., Krauss S.;
RT   "Zebrafish pou[c]: a divergent POU family gene ubiquitously expressed
RT   during embryogenesis.";
RL   Nucleic Acids Res. 21:475-483(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that binds with high affinity to the
CC       motif 5'-TAATGARAT-3'. {ECO:0000269|PubMed:8441661}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed during embryogenesis.
CC       {ECO:0000269|PubMed:8441661}.
CC   -!- SIMILARITY: Belongs to the POU transcription factor family. Class-6
CC       subfamily. {ECO:0000305}.
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DR   EMBL; X68432; CAA48481.1; -; mRNA.
DR   EMBL; BC162134; AAI62134.1; -; mRNA.
DR   EMBL; BC162146; AAI62146.1; -; mRNA.
DR   PIR; S30234; S30234.
DR   RefSeq; NP_571188.1; NM_131113.1.
DR   AlphaFoldDB; P31367; -.
DR   SMR; P31367; -.
DR   STRING; 7955.ENSDARP00000111302; -.
DR   PaxDb; P31367; -.
DR   Ensembl; ENSDART00000130338; ENSDARP00000111302; ENSDARG00000011570.
DR   GeneID; 30334; -.
DR   KEGG; dre:30334; -.
DR   CTD; 5463; -.
DR   ZFIN; ZDB-GENE-980526-530; pou6f1.
DR   eggNOG; KOG3802; Eukaryota.
DR   GeneTree; ENSGT00940000160106; -.
DR   HOGENOM; CLU_013065_6_3_1; -.
DR   InParanoid; P31367; -.
DR   OMA; SEMQPIQ; -.
DR   OrthoDB; 474850at2759; -.
DR   PhylomeDB; P31367; -.
DR   TreeFam; TF350705; -.
DR   PRO; PR:P31367; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 23.
DR   Bgee; ENSDARG00000011570; Expressed in mature ovarian follicle and 25 other tissues.
DR   ExpressionAtlas; P31367; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1905222; P:atrioventricular canal morphogenesis; IMP:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR013847; POU.
DR   InterPro; IPR000327; POU_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF00157; Pou; 1.
DR   PRINTS; PR00028; POUDOMAIN.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00352; POU; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS00035; POU_1; 1.
DR   PROSITE; PS00465; POU_2; 1.
DR   PROSITE; PS51179; POU_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..610
FT                   /note="POU domain, class 6, transcription factor 1"
FT                   /id="PRO_0000100770"
FT   DOMAIN          448..522
FT                   /note="POU-specific"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT   DNA_BIND        543..602
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          55..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..87
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   610 AA;  63124 MW;  51D7140A6F16DD66 CRC64;
     MDTEDLPANN APLTVNEQLL GSCTLKFPAQ DAQVIVMSGQ ETIRVLEVEV DTALSSAGAA
     ESGGDEEGSG QSLEATEEAQ LDGPVTTSST TAVTVEVSAP VVQTVVSKAA ISVSPAQQTS
     VPITVQACPQ VLTQDGLASL MTGMLAQQSS LGQPLLIPLS MAGSVGGQGG LAVLTLPTAT
     VATLPGLAAA SPAGGLLKLP FAGLQAATVL NSVQTQLQAP AQAVLQPQMS ALQAMQQTQT
     TAATTASIVQ KASEPSVSVA TLQTAGLSIN PAIISAASLG AQPQFISSLT TTPIITSAMS
     NVAGLTSQLI TNAQGQVIGT LPLLVNPASL AGAAAASALP AQGLQVQTVA PQLLLNSQGQ
     IIATIGNGPT AAIPSTASVL PKATVPLTLT KTTTQGPVGK VAPSKVIIAP QPSVVKPVTS
     LTAAGVIACG EMPTVGQLVN KPSAVKDEEA INLEEIREFA KNFKIRRLSL GLTQTQVGQA
     LTATEGPAYS QSAICRFEKL DITPKSAQKL KPVLERWLAE AELWNQKGQQ NLMEFVGGEP
     SKKRKRRTSF TPQAIEVLNT YFEKNSLPTG QEITEIAKEL NYDREVVRVW FCNRRQTLKN
     TSKINVFQSQ