A95EF_DROME
ID A95EF_DROME Reviewed; 52 AA.
AC P16548; A8E717; A8E740; Q9VCB0;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 18-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Accessory gland-specific peptide 95EF;
DE AltName: Full=Male accessory gland secretory protein 316;
DE Flags: Precursor;
GN Name=Acp95EF; Synonyms=MSP316, Mst95E; ORFNames=CG17924;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RC STRAIN=Canton-S;
RX PubMed=2109712; DOI=10.1016/0012-1606(90)90284-p;
RA Dibenedetto A.J., Harada H.A., Wolfner M.F.;
RT "Structure, cell-specific expression, and mating-induced regulation of a
RT Drosophila melanogaster male accessory gland gene.";
RL Dev. Biol. 139:134-148(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein may be a precursor of secreted proteins and
CC peptide hormones. {ECO:0000269|PubMed:2109712}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2109712}.
CC -!- TISSUE SPECIFICITY: Main cells of the accessory glands of males.
CC {ECO:0000269|PubMed:2109712}.
CC -!- DEVELOPMENTAL STAGE: In very late pupae and in adults.
CC {ECO:0000269|PubMed:2109712}.
CC -!- INDUCTION: By mating. {ECO:0000269|PubMed:2109712}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABV82341.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=ABV82364.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M32022; AAD13400.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF56263.2; -; Genomic_DNA.
DR EMBL; BT030959; ABV82341.1; ALT_INIT; mRNA.
DR EMBL; BT030982; ABV82364.2; ALT_INIT; mRNA.
DR PIR; A37354; A37354.
DR RefSeq; NP_524898.1; NM_080159.3.
DR AlphaFoldDB; P16548; -.
DR BioGRID; 71006; 4.
DR DIP; DIP-20377N; -.
DR IntAct; P16548; 2.
DR STRING; 7227.FBpp0083946; -.
DR PaxDb; P16548; -.
DR DNASU; 47852; -.
DR EnsemblMetazoa; FBtr0084561; FBpp0083946; FBgn0002863.
DR GeneID; 47852; -.
DR KEGG; dme:Dmel_CG17924; -.
DR CTD; 47852; -.
DR FlyBase; FBgn0002863; Acp95EF.
DR VEuPathDB; VectorBase:FBgn0002863; -.
DR HOGENOM; CLU_3052569_0_0_1; -.
DR PhylomeDB; P16548; -.
DR BioGRID-ORCS; 47852; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 47852; -.
DR PRO; PR:P16548; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0002863; Expressed in testis and 11 other tissues.
DR ExpressionAtlas; P16548; differential.
DR Genevisible; P16548; DM.
DR GO; GO:0005615; C:extracellular space; HDA:FlyBase.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR GO; GO:0019953; P:sexual reproduction; HEP:FlyBase.
PE 2: Evidence at transcript level;
KW Behavior; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PEPTIDE 23..52
FT /note="Accessory gland-specific peptide 95EF"
FT /id="PRO_0000020590"
FT CONFLICT 20
FT /note="T -> S (in Ref. 1; AAD13400)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 52 AA; 5405 MW; A44008BD6057FF2B CRC64;
MASVKLFFIA ILVVALSLNT SAAVLNPSST AKPRFETKDR KLSAGALQSL AG
