PO6F2_MOUSE
ID PO6F2_MOUSE Reviewed; 691 AA.
AC Q8BJI4;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 133.
DE RecName: Full=POU domain, class 6, transcription factor 2;
GN Name=Pou6f2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Spinal ganglion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=11284034; DOI=10.1002/gcc.1116;
RA Perotti D., Testi M.A., Mondini P., Pilotti S., Green E.D., Pession A.,
RA Sozzi G., Pierotti M.A., Fossati-Bellani F., Radice P.;
RT "Refinement within single yeast artificial chromosome clones of a minimal
RT region commonly deleted on the short arm of chromosome 7 in Wilms
RT tumours.";
RL Genes Chromosomes Cancer 31:42-47(2001).
CC -!- FUNCTION: Probable transcription factor likely to be involved in early
CC steps in the differentiation of amacrine and ganglion cells. Recognizes
CC and binds to the DNA sequence 5'-ATGCAAAT-3' (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000255|PROSITE-ProRule:PRU00530}.
CC -!- TISSUE SPECIFICITY: Expressed in kidney, heart, muscle, spleen and
CC ovary, but not in lung. {ECO:0000269|PubMed:11284034}.
CC -!- DEVELOPMENTAL STAGE: At 18 dpc, expressed in kidney, adrenal gland,
CC heart, stomach, muscle and eye, but not in lung and skin.
CC {ECO:0000269|PubMed:11284034}.
CC -!- SIMILARITY: Belongs to the POU transcription factor family. Class-6
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK083772; BAC39017.1; -; mRNA.
DR RefSeq; NP_778171.2; NM_175006.2.
DR AlphaFoldDB; Q8BJI4; -.
DR SMR; Q8BJI4; -.
DR BioGRID; 229987; 1.
DR IntAct; Q8BJI4; 1.
DR STRING; 10090.ENSMUSP00000114173; -.
DR PhosphoSitePlus; Q8BJI4; -.
DR PaxDb; Q8BJI4; -.
DR PRIDE; Q8BJI4; -.
DR DNASU; 218030; -.
DR GeneID; 218030; -.
DR KEGG; mmu:218030; -.
DR UCSC; uc007poh.1; mouse.
DR CTD; 11281; -.
DR MGI; MGI:2443631; Pou6f2.
DR eggNOG; KOG3802; Eukaryota.
DR InParanoid; Q8BJI4; -.
DR OrthoDB; 474850at2759; -.
DR PhylomeDB; Q8BJI4; -.
DR BioGRID-ORCS; 218030; 0 hits in 21 CRISPR screens.
DR ChiTaRS; Pou6f2; mouse.
DR PRO; PR:Q8BJI4; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8BJI4; protein.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013847; POU.
DR InterPro; IPR033056; POU6F2.
DR InterPro; IPR000327; POU_dom.
DR PANTHER; PTHR11636:SF68; PTHR11636:SF68; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 2.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00035; POU_1; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..691
FT /note="POU domain, class 6, transcription factor 2"
FT /id="PRO_0000100763"
FT DOMAIN 476..586
FT /note="POU-specific"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00530"
FT DNA_BIND 607..666
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..234
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..294
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 691 AA; 73309 MW; 501A64262721A70D CRC64;
MIAGQVSKPL LSVRSEMNAE LRGEDKAATS DSELNEPLLA PAESNDSEDT PSKLFGARGN
TVLPDPGTPD QHQACQTHPT FPVGPQPLLT AQQLASAVAG VMPGGPPALN QPILIPFNMA
GQLGGQQGLV LTLPTANLTN IQGLVAAAAA GGIMTLPLQN LQATSSLNSQ LQQLQQLQLQ
QQQQQQQQQQ QQQQQQQQPP PPPTSQHPQP ASQAPPQSQP TPPHQPPPAS QQLPAPPAQL
EQATQPQQHQ PHSHPQNQTQ NQPSPTQQSS SPPQKPSPSP GHSLPSPLTP PNPLQLVNNP
LASQAAAAAA AMGSIASSQA FGNALSSLQG VTGQLVTNAQ GQIIGTIPLM PNPGPSSQAA
SGTQGLQVQP ITPQLLTNAQ GQIIATVIGN QILPVINTQG ITLSPIKPGQ QLHQSSQTSV
GQAGTQGNLL HLAHGQAATS HSPVRQASSS SSSSSSSSAL SVGQLVSNPQ TAAGEVDGVN
LEEIREFAKA FKIRRLSLGL TQTQVGQALS ATEGPAYSQS AICRHTILRS HFFLPQEAQE
NTIASSLTAK LNPGLLYPAR FEKLDITPKS AQKIKPVLER WMAEAEARHR AGMQNLTEFI
GSEPSKKRKR RTSFTPQALE ILNAHFEKNT HPSGQEMTEI AEKLNYDREV VRVWFCNKRQ
ALKNTIKRLK QHEPTSAAPL EPLADSPEEN C
