POB3_CANAL
ID POB3_CANAL Reviewed; 538 AA.
AC Q5ALL8; A0A1D8PGK5;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=FACT complex subunit POB3;
DE AltName: Full=Facilitates chromatin transcription complex subunit POB3;
GN Name=POB3; OrderedLocusNames=CAALFM_C202380WA;
GN ORFNames=CaO19.1560, CaO19.9133;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Component of the FACT complex, a general chromatin factor
CC that acts to reorganize nucleosomes. The FACT complex is involved in
CC multiple processes that require DNA as a template such as mRNA
CC elongation, DNA replication and DNA repair. During transcription
CC elongation the FACT complex acts as a histone chaperone that both
CC destabilizes and restores nucleosomal structure. It facilitates the
CC passage of RNA polymerase II and transcription by promoting the
CC dissociation of one histone H2A-H2B dimer from the nucleosome, then
CC subsequently promotes the reestablishment of the nucleosome following
CC the passage of RNA polymerase II (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms a stable heterodimer with SPT16. The SPT16-POB3 dimer
CC weakly associates with multiple molecules of NHP6 to form the FACT
CC complex (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q04636}.
CC Chromosome {ECO:0000250|UniProtKB:Q04636}. Note=Colocalizes with RNA
CC polymerase II on chromatin. Recruited to actively transcribed loci.
CC {ECO:0000250|UniProtKB:Q04636}.
CC -!- MISCELLANEOUS: In contrast to the orthologous protein in animals and
CC plants, this protein does not contain a HMG box DNA-binding domain.
CC This function may instead be provided by the HMG box of the associated
CC NHP6 protein in the FACT complex of fungi.
CC -!- SIMILARITY: Belongs to the SSRP1 family. {ECO:0000305}.
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DR EMBL; CP017624; AOW27278.1; -; Genomic_DNA.
DR RefSeq; XP_722602.1; XM_717509.1.
DR AlphaFoldDB; Q5ALL8; -.
DR SMR; Q5ALL8; -.
DR BioGRID; 1218921; 1.
DR STRING; 237561.Q5ALL8; -.
DR PRIDE; Q5ALL8; -.
DR GeneID; 3635827; -.
DR KEGG; cal:CAALFM_C202380WA; -.
DR CGD; CAL0000189327; POB3.
DR VEuPathDB; FungiDB:C2_02380W_A; -.
DR eggNOG; KOG0526; Eukaryota.
DR HOGENOM; CLU_017374_3_0_1; -.
DR InParanoid; Q5ALL8; -.
DR OrthoDB; 915055at2759; -.
DR PRO; PR:Q5ALL8; -.
DR Proteomes; UP000000559; Chromosome 2.
DR GO; GO:0035101; C:FACT complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR GO; GO:0009267; P:cellular response to starvation; IMP:CGD.
DR GO; GO:0140719; P:constitutive heterochromatin assembly; IEA:EnsemblFungi.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0036180; P:filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR GO; GO:0036170; P:filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
DR GO; GO:0034728; P:nucleosome organization; IEA:EnsemblFungi.
DR Gene3D; 2.30.29.220; -; 1.
DR Gene3D; 2.30.29.30; -; 2.
DR InterPro; IPR013719; DUF1747.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR035417; POB3_N.
DR InterPro; IPR000969; SSrcognition.
DR InterPro; IPR024954; SSRP1_dom.
DR InterPro; IPR038167; SSRP1_sf.
DR Pfam; PF17292; POB3_N; 1.
DR Pfam; PF08512; Rtt106; 1.
DR Pfam; PF03531; SSrecog; 1.
DR PRINTS; PR00887; SSRCOGNITION.
DR SMART; SM01287; Rtt106; 1.
PE 3: Inferred from homology;
KW Chromosome; DNA damage; DNA repair; DNA replication; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..538
FT /note="FACT complex subunit POB3"
FT /id="PRO_0000245202"
FT REGION 467..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..524
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 538 AA; 60895 MW; D1034962273FDEBE CRC64;
MVNTDFEKIY LNQSRAGGRM RIAESGLGWK ASASSGSTSQ PFLLPREEIL IASWSRGSKG
YELRVQTKNK GVVSLDGFDH DDFTQLKQEL TRNFHINLEH REHSLRGWNW GKTDLARNEL
IFNVNNKPAF EIPYSDISNS NLTGKNEVAL EFNLDNNKNG DEIVEMRFYV PGTIENETTI
VKNETNGDVI EEAVVNETSA AQQFYEQLKD KADIGQVAGE AIVSFSDVLF LTPRGRYDID
MYPSSLRLRG KTYDYKIQYE QIERIFSLPK PDETHHLIVL QIDPPLRQGQ TRYPFLVLQF
VKDEETELEL NVSDEDFEKK YKDRLKKTYD APTNVVMSHC LRGLTERKLI TPGAFQSRYL
QAGVPCSVKA SEGYLFPLDR CFLFVTKPTL YIPYSEISSV VMSRTGGGVS ASRTFDLEVN
VIGSNQPHVF SNIDREEQEF IESFCKEKGV KVKNEEKIAK ARLAKALEQE ANDDDDEDAD
MGSAGDEDED EDVDFQSGSD SDVAEEFDSD AAPSSDDDEE MADSKETDDR PPKKKAKN
