POC16_CHLRE
ID POC16_CHLRE Reviewed; 2083 AA.
AC A8JAN3;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Centriole proteome protein 16 {ECO:0000303|PubMed:28781053};
GN Name=POC16 {ECO:0000303|PubMed:28781053};
GN ORFNames=CHLRE_14g613400v5 {ECO:0000305}, CHLREDRAFT_18900;
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503, and cw92;
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and plant
RT functions.";
RL Science 318:245-250(2007).
RN [2]
RP FUNCTION, DISRUPTION PHENOTYPE, IDENTIFICATION BY MASS SPECTROMETRY, AND
RP SUBCELLULAR LOCATION.
RX PubMed=28781053; DOI=10.1016/j.cub.2017.07.011;
RA Hamel V., Steib E., Hamelin R., Armand F., Borgers S., Flueckiger I.,
RA Busso C., Olieric N., Sorzano C.O.S., Steinmetz M.O., Guichard P.,
RA Goenczy P.;
RT "Identification of chlamydomonas central core centriolar proteins reveals a
RT role for human WDR90 in ciliogenesis.";
RL Curr. Biol. 27:2486-2498(2017).
CC -!- FUNCTION: Required for flagellum assembly and/or maintenance.
CC {ECO:0000269|PubMed:28781053}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriole {ECO:0000269|PubMed:28781053}.
CC -!- DISRUPTION PHENOTYPE: Mutants display shorter flagella and cannot swim.
CC {ECO:0000269|PubMed:28781053}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR90/POC16 family. {ECO:0000305}.
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DR EMBL; DS496150; EDO99093.1; -; Genomic_DNA.
DR EMBL; CM008975; PNW72962.1; -; Genomic_DNA.
DR RefSeq; XP_001699039.1; XM_001698987.1.
DR AlphaFoldDB; A8JAN3; -.
DR STRING; 3055.EDO99093; -.
DR PaxDb; A8JAN3; -.
DR PRIDE; A8JAN3; -.
DR EnsemblPlants; PNW72962; PNW72962; CHLRE_14g613400v5.
DR GeneID; 5724591; -.
DR Gramene; PNW72962; PNW72962; CHLRE_14g613400v5.
DR KEGG; cre:CHLRE_14g613400v5; -.
DR eggNOG; KOG0266; Eukaryota.
DR eggNOG; KOG3213; Eukaryota.
DR HOGENOM; CLU_002454_0_0_1; -.
DR InParanoid; A8JAN3; -.
DR OMA; HATEYNI; -.
DR OrthoDB; 255317at2759; -.
DR Proteomes; UP000006906; Chromosome 14.
DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 6.
DR InterPro; IPR007714; CFA20_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF05018; DUF667; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 16.
DR SUPFAM; SSF50978; SSF50978; 2.
DR SUPFAM; SSF50998; SSF50998; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..2083
FT /note="Centriole proteome protein 16"
FT /id="PRO_0000445432"
FT REPEAT 482..523
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 526..569
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 579..620
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 689..726
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 728..767
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 770..809
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 812..853
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REPEAT 856..895
FT /note="WD 8"
FT /evidence="ECO:0000255"
FT REPEAT 990..1029
FT /note="WD 9"
FT /evidence="ECO:0000255"
FT REPEAT 1041..1079
FT /note="WD 10"
FT /evidence="ECO:0000255"
FT REPEAT 1326..1365
FT /note="WD 11"
FT /evidence="ECO:0000255"
FT REPEAT 1403..1444
FT /note="WD 12"
FT /evidence="ECO:0000255"
FT REPEAT 1448..1486
FT /note="WD 13"
FT /evidence="ECO:0000255"
FT REPEAT 1497..1539
FT /note="WD 14"
FT /evidence="ECO:0000255"
FT REPEAT 1651..1691
FT /note="WD 15"
FT /evidence="ECO:0000255"
FT REPEAT 1736..1781
FT /note="WD 16"
FT /evidence="ECO:0000255"
FT REPEAT 1785..1824
FT /note="WD 17"
FT /evidence="ECO:0000255"
FT REPEAT 2035..2073
FT /note="WD 18"
FT /evidence="ECO:0000255"
FT REGION 205..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1113..1141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1225..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1713..1743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1832..1870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1226..1242
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1260..1276
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2083 AA; 214904 MW; 4BCCB4FDF6ABA400 CRC64;
MSLAPEWQHP FVNIFKLCDV DTMREFETKG DVTEHIDKII GKKVFKIRGM IPAGNYLRVP
RTKLQTLGLT GRLLYIQLKV TPIKVFAIHI EVVTEDHNIH RISISNMYNP ESMKRKSNGV
QLPFPKPSHR WCVLAVDLRE ALRGYTSSPF ASVKAVQTCS WMTVRTMFAS DYKFSLQSLP
GDMALSHALD SSLFEMVWLP AEPQDAPTMD FMPPPKRYGT RARRPGTAET ADTAGAAGRK
SLSGASAGGA GPAKGGAKAG AAAGGKRAVS SAGATRGTPS QRGSTAGAAT PGSGAGGGGH
DGEEDFEDDL SEDLDNGAPL PPSPAVPPPL SPSVAARIAG RATSANIGAA TAAGAIVGAA
AAHPRPGESD ASARPFPRPT TALLAGAATT ASLRPPIASA NVAKPEPGQP AAQPLLPDPA
LTLTRVNAYS GEFVRCLAWL PGTDEVVFAA ASVVVIMGVA DPGAAAQQQA AVTPGRQRYC
LGHTAFVCAL AVASDGRLLA SCQEGKEAIV RLWDTANCAC LAILNAHASG LSCVDLSPDL
RALAAVGLDV QGRQTIALWN IAELRAAGGP KVELVTRHAT EYNIKVLKFS AYQEDHLLTA
GRDSIRIYRL KAGQLRGTSV RLVPQDKRVT SFAGGVSAAV GPNIFTDIGF EAGVGVYGVD
AFKVYVSSAS GALFVVDYTT RQLDAIFQLH AAAINCLVVS DGLVLTGGDD RLLRAWPLDF
RDYLLEAEHE GAVTGLAMST DALRLAVGTE NGTLGVLAIP THAYTTLLRS HCGAVNAVAV
DPNRDQYCTV SSDGTLRIWH LATHQQLYEF DAPGEAVSAI AYHPHPSHHE LAAGFANGRL
RVFDVPSTTL LQEHHQHRAG ITELLFSPGG DRLFSGGADG ALVVYDTARM YAPAQYLSAG
VRDIKVCCAV SSNGAFFASL VRDPYRRTTS LLVFHGRTLD PFMRIETDAA AYVKLAFSAD
CNELWALTSG RRLDRYELKD GQLVQQIHEV SPLELTALCL DPAGRYAATA GADGLLRLWG
CVPLPALRGL KGLPPNSAFL GHPSAILGAA FHRSGYLVTV GDADCVCVWR VNADHMQQER
GHLAAAAHAL RGAAAGGGAA GASPLLLQGA AHHTQATGAL DPTDPRSRAH PSTALGPVAS
ARDHQLTTRA AALGTPLPAG VLGLVPAPSA FTGTYTQGMA APSLGSTVAS PTRVTAATAN
SMAALSLVAN SPAVAATAPG LPSHALVVPK PSPPPPSAAP ASPGRSPNRA LAGAGPARSR
LPVPLPPSPQ PLPPPPPPRC SWLLGYSPTG SSNVAWNATT GLFCYVVEDM VVMEKLATRQ
QRYLRGHNRP LSCLAASPDG ALVAAGPAAA EPAFTEPAAG ARAAQLQQQG VAVGPGGASP
TAPFADVVVW EAASGRELWR LRYHPLGVQA LAFSPDGRWL VSLGRDPERG VVVWDVAAGL
LVAAGRTEQS PRAAAWLWGG HNPAFATAGA DGLLLWTLQD NFLEQRTVPL SPTASPRDPR
PVTALAVDPH GALLAAEAPA APGSQVPVWQ VQVELQPPQE PGGEAAVAPG GGGGMSAAVV
QVAALPSGCV VTAMAAGLDF ALLATDGGSV VRYRRSTLSG TWLESSAVRL DGRVAALSAE
PNMCDAVAAT DTATIWFVGM QDASCVPIVC GQAAPVTGLV PAPHSGRVMA STAADGLLRV
WRLGPEDAEP ALELHSTSPA TAAAFLLRQP TDAPAHTLRH PPSAAPSSAA SSSPLDPLDP
LPAADAAPAR PVLLPAPHLL GGYGDGSLRL FALEPAVQLS WALARHPAPV VGVAPHPRRG
LVLSASSDGS LAVTDLSSTR LVSYITAFTA AGPTPHSPGG TGRRSPRGAA SPPPAPPRPG
TGPLQAMAVS SGPGAPLAAL AWRDRLVVFA APWDDPACSP LAEYDVTPSD GRTDAADSHG
LLSPDVPACL AFVNSSSGSS SSGTSAASPG LSAHLGGSSS GAPSSKLLAY ASPLLPGTVL
LYDVRLAAVA RRVRLPQMVR SLAVAPDGGA MVVGCMGRSV FLVHLASGNT EELGGHAGAV
AAASYTGDGG HAVTASGSVL MVWDAAQLLK GVTPPPPRML REF
