ID   POC1A_DANRE             Reviewed;         416 AA.
AC   Q7ZVF0;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=POC1 centriolar protein homolog A {ECO:0000250|UniProtKB:Q8NBT0};
DE   AltName: Full=WD repeat domain 51A {ECO:0000312|EMBL:AAH45888.1};
GN   Name=poc1a {ECO:0000312|ZFIN:ZDB-GENE-040426-1993};
GN   Synonyms=wdr51a {ECO:0000312|ZFIN:ZDB-GENE-040426-1993};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:AAH45888.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB {ECO:0000312|EMBL:AAH45888.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play an important role in centriole assembly and/or
CC       stability and ciliogenesis. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat POC1 family. {ECO:0000305}.
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DR   EMBL; BC045888; AAH45888.1; -; mRNA.
DR   RefSeq; NP_998214.1; NM_213049.1.
DR   AlphaFoldDB; Q7ZVF0; -.
DR   SMR; Q7ZVF0; -.
DR   STRING; 7955.ENSDARP00000099551; -.
DR   PRIDE; Q7ZVF0; -.
DR   GeneID; 406322; -.
DR   KEGG; dre:406322; -.
DR   CTD; 25886; -.
DR   ZFIN; ZDB-GENE-040426-1993; poc1a.
DR   eggNOG; ENOG502QSVJ; Eukaryota.
DR   InParanoid; Q7ZVF0; -.
DR   OrthoDB; 1196215at2759; -.
DR   PhylomeDB; Q7ZVF0; -.
DR   Reactome; R-DRE-8951664; Neddylation.
DR   Reactome; R-DRE-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   PRO; PR:Q7ZVF0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005814; C:centriole; IBA:GO_Central.
DR   GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 4.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 7.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cilium biogenesis/degradation; Coiled coil; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..416
FT                   /note="POC1 centriolar protein homolog A"
FT                   /id="PRO_0000395866"
FT   REPEAT          16..55
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          58..97
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          100..139
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          142..181
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          184..223
FT                   /note="WD 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          226..265
FT                   /note="WD 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          268..307
FT                   /note="WD 7"
FT                   /evidence="ECO:0000255"
FT   REGION          311..340
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          380..412
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        325..340
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   416 AA;  45728 MW;  9095C3151820AB79 CRC64;
     MSSALDDPTL ERNFKGHRDA ITSLDFSPSG KQIASGSVDA SVMVWNMKPQ SRAYRFTGHK
     DAVTCVQFSP SAHLLASSSR DKTVRLWVPS VKGESVLFRA HTGSVRSVCF SADGQSLLTA
     SDDQSIKLWS VHRQKIICTL REHNNWVRCA RFSPDGQLMV SVSDDRTVKL WDASSRQLIH
     TFCEPGGYSS YVDFHPSSTC IATASSDNTV RVWDIRTHTL LQHYQVHSAA VNALSFHPSG
     NHLLTASSDS TLKILDLLEG RLLYTLHGHQ GSASCVSFSR SGDQFASAGS DQQVMVWRTN
     FDSVDYSRVL QQKRDHRTPS AQASGAAGDP ESRSGQKTEV SPLLGVSAER SVREPTPQQQ
     TDADGVPAAL TSTLQHIIGQ LDVLTQTVAI LEQRLTLTED KLKECLEQQH QALTEH