ID   POC1A_XENLA             Reviewed;         441 AA.
AC   Q7T0P4;
DT   28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2012, sequence version 2.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=POC1 centriolar protein homolog A;
DE   AltName: Full=Pat-interacting protein 2;
DE            Short=Pix2;
DE            Short=xPix2;
DE   AltName: Full=WD repeat-containing protein 51A;
GN   Name=poc1a; Synonyms=wdr51a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   INTERACTION WITH PAT, AND SUBCELLULAR LOCATION.
RX   PubMed=18068700; DOI=10.1016/j.yexcr.2007.10.019;
RA   Hames R.S., Hames R., Prosser S.L., Euteneuer U., Lopes C.A., Moore W.,
RA   Woodland H.R., Fry A.M.;
RT   "Pix1 and Pix2 are novel WD40 microtubule-associated proteins that
RT   colocalize with mitochondria in Xenopus germ plasm and centrosomes in human
RT   cells.";
RL   Exp. Cell Res. 314:574-589(2008).
CC   -!- FUNCTION: May play an important role in centriole assembly and/or
CC       stability and ciliogenesis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with pat. {ECO:0000269|PubMed:18068700}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000269|PubMed:18068700}. Note=Colocalizes with mitochondria in
CC       cortical germ plasm islands. The mitochondrial localization may be
CC       microtubule-dependent.
CC   -!- SIMILARITY: Belongs to the WD repeat POC1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH56099.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC056099; AAH56099.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001079883.2; NM_001086414.1.
DR   AlphaFoldDB; Q7T0P4; -.
DR   SMR; Q7T0P4; -.
DR   MaxQB; Q7T0P4; -.
DR   DNASU; 379573; -.
DR   GeneID; 379573; -.
DR   KEGG; xla:379573; -.
DR   CTD; 379573; -.
DR   Xenbase; XB-GENE-5767146; poc1a.L.
DR   OrthoDB; 1196215at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 379573; Expressed in egg cell and 15 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 7.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..441
FT                   /note="POC1 centriolar protein homolog A"
FT                   /id="PRO_0000420364"
FT   REPEAT          16..55
FT                   /note="WD 1"
FT   REPEAT          58..97
FT                   /note="WD 2"
FT   REPEAT          100..139
FT                   /note="WD 3"
FT   REPEAT          142..181
FT                   /note="WD 4"
FT   REPEAT          184..223
FT                   /note="WD 5"
FT   REPEAT          226..265
FT                   /note="WD 6"
FT   REPEAT          268..307
FT                   /note="WD 7"
FT   REGION          347..376
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          400..427
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        358..376
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   441 AA;  48842 MW;  E7226BB1BBCC52AD CRC64;
     MAGQSEDPSL ERHFKGHRDT VTAVDFNANT KQLASGSMDS CLMVWNMKTQ MRAYRFVGHK
     DAILSVDFSP SGHLIASASR DKTVRLWVPS VKGESTAFKA HTGTVRSVSF SGDGQSLVTA
     SDDKTIKVWT VHRQKFLFSL NQHINWVRCA KFSPDGRLIV SASDDKTIKL WDKTSRECIQ
     SFCEHGGFVN FVDFHPSGTC IAAAATDNTV KVWDIRMNKL IQHYQVHSGV VNSLSFHPSG
     NYLITASNDS TLKVLDLLEG RLLYTLHGHQ GPVTCVKFSR EGDFFASGGS DEQVMVWKTN
     FDAGSYPDLL KYRQNDTFPS GGDYTSIVQP ADVHQPARNA HVTQAADLEP HITEMSVKDR
     SSPLSYTSRS VDQHHPQAED GNLQTVASTL EHIVGQLDIL TRTVGILEQR LSLTEDKLKE
     CIEQQQATVP PSHSGTKKSS F