ID   POC1A_XENTR             Reviewed;         441 AA.
AC   Q28I85;
DT   28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=POC1 centriolar protein homolog A;
DE   AltName: Full=Pat-interacting protein 2;
DE            Short=Pix2;
DE            Short=xPix2;
DE   AltName: Full=WD repeat-containing protein 51A;
GN   Name=poc1a; Synonyms=wdr51a;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play an important role in centriole assembly and/or
CC       stability and ciliogenesis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with pat. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC       Note=Colocalizes with mitochondria in cortical germ plasm islands. The
CC       mitochondrial localization may be microtubule-dependent (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat POC1 family. {ECO:0000305}.
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DR   EMBL; BC158994; AAI58995.1; -; mRNA.
DR   EMBL; CR760535; CAJ83727.1; -; mRNA.
DR   RefSeq; NP_001016608.1; NM_001016608.2.
DR   AlphaFoldDB; Q28I85; -.
DR   SMR; Q28I85; -.
DR   STRING; 8364.ENSXETP00000038715; -.
DR   GeneID; 549362; -.
DR   KEGG; xtr:549362; -.
DR   CTD; 25886; -.
DR   Xenbase; XB-GENE-5767105; poc1a.
DR   InParanoid; Q28I85; -.
DR   OrthoDB; 1196215at2759; -.
DR   Reactome; R-XTR-8951664; Neddylation.
DR   Reactome; R-XTR-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000010813; Expressed in 2-cell stage embryo and 9 other tissues.
DR   GO; GO:0005814; C:centriole; IBA:GO_Central.
DR   GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 7.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome; Repeat;
KW   WD repeat.
FT   CHAIN           1..441
FT                   /note="POC1 centriolar protein homolog A"
FT                   /id="PRO_0000420365"
FT   REPEAT          16..55
FT                   /note="WD 1"
FT   REPEAT          58..97
FT                   /note="WD 2"
FT   REPEAT          100..139
FT                   /note="WD 3"
FT   REPEAT          142..181
FT                   /note="WD 4"
FT   REPEAT          184..223
FT                   /note="WD 5"
FT   REPEAT          226..265
FT                   /note="WD 6"
FT   REPEAT          268..307
FT                   /note="WD 7"
FT   REGION          323..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          400..427
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        330..356
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        358..372
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   441 AA;  49174 MW;  C92CAE6B8A9D8742 CRC64;
     MAGQPEDPSL ERHFKGHRDT VTTVDFNPNT KQLASGSMDS CLMIWNMKPQ MRAYRFVGHK
     DAILSVDFSP SGHLIASASR DKTVRLWVPS VKGESTVFKA HTGTVRSVSF SGDGQSLVTA
     SDDKTIKVWT VHRQKFLFSL NQHINWVRCA KFSPDGRLIV SASDDKTIKL WDKTSRECIH
     SFCEHGGFVN FVDFHPSGTC IAAAATDNTV KVWDIRMNKL IQHYQVHSGV VNSLSFHPSG
     NYLITASNDS TLKVLDLLEG RLLYTLHGHQ GPVTSVKFSR EGEFFASGGS DEQVMVWKTN
     FDSASYADLL KYRQHDQFLN GGDYTSGVPA ADRHRPERNA QTDQADDLEP RHIQMSAKDR
     SSPLSYTSRS IDQHHPQAED GNLRTVASTL EHIVGQLDIL TRTVGILEQR LSLTEDKLKE
     CIDNQQATVS LSHSATKTPS F