ID   POC1B_PONAB             Reviewed;         451 AA.
AC   Q5RD06;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=POC1 centriolar protein homolog B;
DE   AltName: Full=WD repeat-containing protein 51B;
GN   Name=POC1B; Synonyms=WDR51B;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in centriole assembly and/or
CC       stability and ciliogenesis. Involved in early steps of centriole
CC       duplication, as well as in the later steps of centriole length control.
CC       Acts in concert with POC1A to ensure centriole integrity and proper
CC       mitotic spindle formation. Required for primary cilia formation,
CC       ciliary length and also cell proliferation. Required for retinal
CC       integrity. {ECO:0000250|UniProtKB:Q8TC44}.
CC   -!- SUBUNIT: Interacts with POC1A. Interacts with FAM161A. Interacts with
CC       CEP44; the interaction is direct and recruits POC1B to centriolar
CC       microtubules. {ECO:0000250|UniProtKB:Q8TC44}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000250|UniProtKB:Q8TC44}.
CC       Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250|UniProtKB:Q8TC44}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250|UniProtKB:Q8TC44}. Note=Component of both mother and
CC       daughter centrioles. Localizes to the basal body and centriole adjacent
CC       to the connecting cilium of photoreceptors and in synapses of the outer
CC       plexiform layer. {ECO:0000250|UniProtKB:Q8BHD1,
CC       ECO:0000250|UniProtKB:Q8TC44}.
CC   -!- PTM: Phosphorylated in mitotic cells that may be mediated by CDK1.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat POC1 family. {ECO:0000305}.
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DR   EMBL; CR858112; CAH90351.1; -; mRNA.
DR   RefSeq; NP_001125169.1; NM_001131697.2.
DR   AlphaFoldDB; Q5RD06; -.
DR   SMR; Q5RD06; -.
DR   STRING; 9601.ENSPPYP00000005494; -.
DR   GeneID; 100172056; -.
DR   KEGG; pon:100172056; -.
DR   CTD; 282809; -.
DR   eggNOG; ENOG502QSVJ; Eukaryota.
DR   InParanoid; Q5RD06; -.
DR   OrthoDB; 1196215at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
DR   GO; GO:0008283; P:cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0007099; P:centriole replication; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0001895; P:retina homeostasis; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 7.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Coiled coil; Cytoplasm;
KW   Cytoskeleton; Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..451
FT                   /note="POC1 centriolar protein homolog B"
FT                   /id="PRO_0000051412"
FT   REPEAT          16..55
FT                   /note="WD 1"
FT   REPEAT          58..99
FT                   /note="WD 2"
FT   REPEAT          101..139
FT                   /note="WD 3"
FT   REPEAT          142..181
FT                   /note="WD 4"
FT   REPEAT          183..223
FT                   /note="WD 5"
FT   REPEAT          226..265
FT                   /note="WD 6"
FT   REPEAT          268..307
FT                   /note="WD 7"
FT   REGION          372..394
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          404..443
FT                   /evidence="ECO:0000255"
FT   MOD_RES         321
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TC44"
SQ   SEQUENCE   451 AA;  50713 MW;  8F3CB7FE8A4DDE12 CRC64;
     MASATEDPVL ERYFKGHKAA ITSLDLSPNG KQLATASWDT FLMLWNFKPH ARAYRYVGHK
     DVVTSVQFSP HGNLLASASR DRTVRLWIPD KRGKFSEFKA HTAPVRSVDF SADGQFLATA
     SEDKSIKVWS MYRQRFLYSL YRHTHWVRCA KFSPDGRLIV SCSEDKTIKI WDTTNKQCVN
     NFSDSVGFAN FVDFNPSGTC IASAGSDQTV KVWDVRVNKL LQHYQVHSGG VNCISFHPSD
     NYLVTASSDG TLKILDLLEG RLIYTLQGHT GPVFTVSFSK GGELFASGGA DTQVLLWRTN
     FDELHCKGLN KRNLKRLHFD SPPHLLDIYP RTPHPHEEKV ETVETTETSG RTLPDKGEEA
     CGYFLNPSLM SPECSPTTTK KKTEDMSDLP SESQRSIPLA VTDALEHIME QLNVLTQTVS
     ILEQRLTLTE DKLKDCLENQ QKLFSAVQQK S