ID   POC1B_XENLA             Reviewed;         468 AA.
AC   Q4V7Z1;
DT   28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=POC1 centriolar protein homolog B;
DE   AltName: Full=Pat-interacting protein 1;
DE            Short=Pix1;
DE            Short=xPix1;
DE   AltName: Full=WD repeat-containing protein 51B;
GN   Name=poc1b; Synonyms=wdr51b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH PAT, SUBCELLULAR LOCATION,
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=18068700; DOI=10.1016/j.yexcr.2007.10.019;
RA   Hames R.S., Hames R., Prosser S.L., Euteneuer U., Lopes C.A., Moore W.,
RA   Woodland H.R., Fry A.M.;
RT   "Pix1 and Pix2 are novel WD40 microtubule-associated proteins that
RT   colocalize with mitochondria in Xenopus germ plasm and centrosomes in human
RT   cells.";
RL   Exp. Cell Res. 314:574-589(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in centriole assembly and/or
CC       stability and ciliogenesis. Involved in early steps of centriole
CC       duplication, as well as in the later steps of centriole length control.
CC       {ECO:0000250|UniProtKB:Q8TC44, ECO:0000269|PubMed:18068700}.
CC   -!- SUBUNIT: Interacts with pat. {ECO:0000269|PubMed:18068700}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000250|UniProtKB:Q8TC44}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in ovary and, at low levels, in
CC       testis. {ECO:0000269|PubMed:18068700}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in eggs and early stage embryos. Strong
CC       expression is maintained until stage 8. {ECO:0000269|PubMed:18068700}.
CC   -!- SIMILARITY: Belongs to the WD repeat POC1 family. {ECO:0000305}.
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DR   EMBL; BC097649; AAH97649.1; -; mRNA.
DR   EMBL; DQ861903; ABI17539.1; -; mRNA.
DR   RefSeq; NP_001089468.1; NM_001095999.1.
DR   AlphaFoldDB; Q4V7Z1; -.
DR   SMR; Q4V7Z1; -.
DR   DNASU; 734519; -.
DR   GeneID; 734519; -.
DR   KEGG; xla:734519; -.
DR   CTD; 734519; -.
DR   Xenbase; XB-GENE-944936; poc1b.L.
DR   OMA; HYKAHEA; -.
DR   OrthoDB; 1196215at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 734519; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0007099; P:centriole replication; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 7.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Cilium biogenesis/degradation; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..468
FT                   /note="POC1 centriolar protein homolog B"
FT                   /id="PRO_0000420367"
FT   REPEAT          16..55
FT                   /note="WD 1"
FT   REPEAT          58..97
FT                   /note="WD 2"
FT   REPEAT          100..139
FT                   /note="WD 3"
FT   REPEAT          142..181
FT                   /note="WD 4"
FT   REPEAT          184..223
FT                   /note="WD 5"
FT   REPEAT          226..265
FT                   /note="WD 6"
FT   REPEAT          268..307
FT                   /note="WD 7"
FT   COILED          420..459
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   468 AA;  52116 MW;  35C18B528D2E5564 CRC64;
     MASALDDPAL QRHFKGHKDA VTCVDFSPDS KQLASSSADA CVMIWNFKPQ SRAYKYPGHK
     EAVTCVQFSP SGHLVASSSK DRTVRLWAPN IKGESTVLKA HTAVVRCVNF SSDGQTFITA
     SDDKSIKAWN LHRQRFLFSL TQHTNWVRCA RFSPDGRLIA SCSDDKTVRI WDLTNRLCIN
     TFVDYKGHSN YVDFNQMGTC VASAGADSTV KVWDIRMNKL LQHYQVHNAG VSSLSFHPSG
     NYLLTASSDG TLKILDLLEG RLIYTLHGHQ GPVLSVTFSK SGDQFASGAT DAQVLVWKTN
     FDKYSVKEIV KLQQKRTCPE APPHLNDIYP RTPHLHSSSG HSIEINPMCE VADTQTFDPP
     IINVGANLPY CRRTKAVHTL NKHVRNDNYP TPPVAFSYTE GQKEHPLVEE QGVLPPSLSN
     TLEQIVDQLN VLTQTVSILE HRLTLTEDKL KECLENQQKT SAHASESD