POC1B_XENTR
ID POC1B_XENTR Reviewed; 470 AA.
AC F6ZT52; Q6DIJ0;
DT 28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=POC1 centriolar protein homolog B;
DE AltName: Full=WD repeat-containing protein 51B;
DE AltName: Full=WD40 repeat protein Pix1;
GN Name=poc1b; Synonyms=wdr51b;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Egg;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an important role in centriole assembly and/or
CC stability and ciliogenesis. Involved in early steps of centriole
CC duplication, as well as in the later steps of centriole length control.
CC {ECO:0000250|UniProtKB:Q8TC44}.
CC -!- SUBUNIT: Interacts with pat. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriole {ECO:0000250|UniProtKB:Q8TC44}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F6ZT52-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F6ZT52-2; Sequence=VSP_044440, VSP_044439;
CC -!- SIMILARITY: Belongs to the WD repeat POC1 family. {ECO:0000305}.
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DR EMBL; CU024965; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AAMC01065522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC075548; AAH75548.1; -; mRNA.
DR RefSeq; NP_001004988.1; NM_001004988.1. [F6ZT52-2]
DR RefSeq; XP_012814294.1; XM_012958840.2. [F6ZT52-1]
DR AlphaFoldDB; F6ZT52; -.
DR SMR; F6ZT52; -.
DR STRING; 8364.ENSXETP00000047331; -.
DR PaxDb; F6ZT52; -.
DR PRIDE; F6ZT52; -.
DR DNASU; 448445; -.
DR Ensembl; ENSXETT00000091115; ENSXETP00000095229; ENSXETG00000021865.
DR GeneID; 448445; -.
DR KEGG; xtr:448445; -.
DR CTD; 282809; -.
DR Xenbase; XB-GENE-944930; poc1b.
DR eggNOG; ENOG502QSVJ; Eukaryota.
DR HOGENOM; CLU_000288_57_17_1; -.
DR InParanoid; F6ZT52; -.
DR OMA; HYKAHEA; -.
DR OrthoDB; 1196215at2759; -.
DR PhylomeDB; F6ZT52; -.
DR TreeFam; TF324210; -.
DR Proteomes; UP000008143; Chromosome 3.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000021865; Expressed in egg cell and 11 other tissues.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0007099; P:centriole replication; ISS:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cilium biogenesis/degradation; Coiled coil;
KW Cytoplasm; Cytoskeleton; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..470
FT /note="POC1 centriolar protein homolog B"
FT /id="PRO_0000420368"
FT REPEAT 16..55
FT /note="WD 1"
FT REPEAT 58..97
FT /note="WD 2"
FT REPEAT 100..139
FT /note="WD 3"
FT REPEAT 142..181
FT /note="WD 4"
FT REPEAT 184..223
FT /note="WD 5"
FT REPEAT 226..265
FT /note="WD 6"
FT REPEAT 268..307
FT /note="WD 7"
FT COILED 418..461
FT /evidence="ECO:0000255"
FT VAR_SEQ 374..379
FT /note="TKALHT -> AGTCKL (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_044440"
FT VAR_SEQ 380..470
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_044439"
SQ SEQUENCE 470 AA; 52397 MW; 8FDE94F29B1E339C CRC64;
MASALEDPAL QRHFKGHKDA VTYVDFSPDG KQLASSSADA CVMIWNFKPQ SRAYKYPGHK
EAVTCVQFSP SGHLVASSSK DRTVRLWAPN IKGESSVLKA HTAVVRCVNF SSDGHTFITA
SDDKSIKAWN LHRQRFLYSL TEHTNWVRCA RFSPDGRLIA SCSDDKTVRI WDITNRLCIN
TFVDYKGHSN YVDFNPMGTC VASAGVDSTV KVWDIRTNKL LQHYQVHNAG VNSLSFHPSG
NYLLTASNDG TVKILDLLEG RLIYTLHGHQ GPVLSVAFSK SGDQFASGAT DAQVLVWKTN
FDKYNIKEIV KLQQKRTCPE APPHLNDIYP KTPHLHTSSG HSIEINPMFE LADTQTFDPP
IIDVGANFPY CRQTKALHTL NKYERNDNVC NYPMPPLASS VEGQKEHPLV GVQGALPRSL
SNTLEQIVDQ LNVLTQTVSI LEHRLTLTED KLKECLENQQ KIPAHASESD
