POC1_DROME
ID POC1_DROME Reviewed; 391 AA.
AC Q9VU65;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=POC1 centriolar protein homolog;
DE AltName: Full=Proteome of centrioles 1;
GN Name=Poc1; ORFNames=CG10191;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAL39494.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL39494.1};
RC TISSUE=Embryo {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4] {ECO:0000305}
RP FUNCTION.
RX PubMed=19293139; DOI=10.1534/genetics.109.101709;
RA Blachon S., Cai X., Roberts K.A., Yang K., Polyanovsky A., Church A.,
RA Avidor-Reiss T.;
RT "A proximal centriole-like structure is present in Drosophila spermatids
RT and can serve as a model to study centriole duplication.";
RL Genetics 182:133-144(2009).
CC -!- FUNCTION: Plays an important role in centriole formation.
CC {ECO:0000269|PubMed:19293139}.
CC -!- SIMILARITY: Belongs to the WD repeat POC1 family. {ECO:0000305}.
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DR EMBL; AE014296; AAF49825.1; -; Genomic_DNA.
DR EMBL; AY069349; AAL39494.1; -; mRNA.
DR RefSeq; NP_648640.1; NM_140383.2.
DR AlphaFoldDB; Q9VU65; -.
DR SMR; Q9VU65; -.
DR IntAct; Q9VU65; 1.
DR STRING; 7227.FBpp0302861; -.
DR PaxDb; Q9VU65; -.
DR PRIDE; Q9VU65; -.
DR DNASU; 39502; -.
DR EnsemblMetazoa; FBtr0075863; FBpp0075597; FBgn0036354.
DR GeneID; 39502; -.
DR KEGG; dme:Dmel_CG10191; -.
DR UCSC; CG10191-RA; d. melanogaster.
DR CTD; 39502; -.
DR FlyBase; FBgn0036354; Poc1.
DR VEuPathDB; VectorBase:FBgn0036354; -.
DR eggNOG; ENOG502QSVJ; Eukaryota.
DR GeneTree; ENSGT00940000157494; -.
DR HOGENOM; CLU_000288_57_17_1; -.
DR InParanoid; Q9VU65; -.
DR OMA; SEMDCGI; -.
DR OrthoDB; 1196215at2759; -.
DR PhylomeDB; Q9VU65; -.
DR Reactome; R-DME-8951664; Neddylation.
DR Reactome; R-DME-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR BioGRID-ORCS; 39502; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 39502; -.
DR PRO; PR:Q9VU65; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0036354; Expressed in testis and 45 other tissues.
DR ExpressionAtlas; Q9VU65; baseline and differential.
DR Genevisible; Q9VU65; DM.
DR GO; GO:0005814; C:centriole; IBA:GO_Central.
DR GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR GO; GO:0007098; P:centrosome cycle; IMP:FlyBase.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..391
FT /note="POC1 centriolar protein homolog"
FT /id="PRO_0000395868"
FT REPEAT 16..55
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 58..97
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 100..139
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 142..183
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 185..223
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 226..265
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 268..307
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REGION 321..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 391 AA; 42810 MW; 88666D933DE2A5CD CRC64;
MQGLFRDPAL ERHFTGHSGG ITQLRFGPDG AQIATSSTDS TVILWNLNQA ARCIRFASHS
APVNGVAWSP KGNLVASAGH DRTVKIWEPK LRGVSGEFVA HSKAVRSVDF DSTGHLMLTA
SDDKSAKIWR VARRQFVSSF AQQNNWVRSA KFSPNGKLVA TASDDKSVRI YDVDSGECVR
TFTEERAAPR QLAWHPWGNM LAVALGCNRI KIFDVSGSQL LQLYVVHSAP VNDVAFHPSG
HFLLSGSDDR TIRILDLLEG RPIYTLTGHT DAVNAVAFSR DGDKFATGGS DRQLLVWQSN
LHTYDASQFE AKSALASSSC ESSGVSSKQS EGSSTSKSND LSIRIDPRQS LAYQLSEENF
QVLDSKHSTQ PEKVLGHGMD FKQHSSSPRF F
