POC1_TETTS
ID POC1_TETTS Reviewed; 634 AA.
AC Q229Z6;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2006, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=POC1 centriolar protein homolog;
GN ORFNames=TTHERM_01308010;
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017;
RN [1] {ECO:0000305, ECO:0000312|EMBL:EAR82115.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000312|EMBL:EAR82115.1};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RC STRAIN=B, B2086, CU427, and CU428;
RX PubMed=20008567; DOI=10.1083/jcb.200908019;
RA Pearson C.G., Osborn D.P., Giddings T.H. Jr., Beales P.L., Winey M.;
RT "Basal body stability and ciliogenesis requires the conserved component
RT Poc1.";
RL J. Cell Biol. 187:905-920(2009).
CC -!- FUNCTION: Required for structural maintenance of centrioles,
CC ciliogenesis, and cilia-based motility. {ECO:0000269|PubMed:20008567}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000269|PubMed:20008567}.
CC -!- DISRUPTION PHENOTYPE: POC1-deficient mutant cells display a
CC temperature-sensitive lethal phenotype. Mutant cells also exhibit
CC reduced basal body frequency, basal body organization defects, and loss
CC of oral apparatuses. {ECO:0000269|PubMed:20008567}.
CC -!- SIMILARITY: Belongs to the POC1 family. {ECO:0000305}.
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DR EMBL; GG662475; EAR82115.1; -; Genomic_DNA.
DR RefSeq; XP_001029778.1; XM_001029778.3.
DR AlphaFoldDB; Q229Z6; -.
DR SMR; Q229Z6; -.
DR STRING; 5911.EAR82115; -.
DR PRIDE; Q229Z6; -.
DR EnsemblProtists; EAR82115; EAR82115; TTHERM_01308010.
DR GeneID; 7835570; -.
DR KEGG; tet:TTHERM_01308010; -.
DR eggNOG; ENOG502QSVJ; Eukaryota.
DR HOGENOM; CLU_000288_57_17_1; -.
DR InParanoid; Q229Z6; -.
DR OrthoDB; 1196215at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0036064; C:ciliary basal body; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0007098; P:centrosome cycle; IMP:UniProtKB.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR024977; Apc4_WD40_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 7.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW Cytoskeleton; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..634
FT /note="POC1 centriolar protein homolog"
FT /id="PRO_0000395869"
FT REPEAT 45..84
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 87..126
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 129..168
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 171..210
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 228..267
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 270..309
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 312..351
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 634 AA; 71332 MW; 0E9825405AB1F5AA CRC64;
MKKTTIASSA VASQKQTQSK LGNTSSKITE QQTTHDPALS RSFRGHEDII TCADFDPKMR
QVASCSKDSI VYVWNFKPQQ RPFKFVGHKG AVYCVKYSPD GETIASCGQD RQIRLWQNTV
QSKCSIIKAH CGAIRSMSFS ADGGYLLSSS DDKTLKLWRL QDKKFMCSFA GHKNWVRSGV
ISPDMRLVAS GSDDKTVMLW DLNFQKIVSK YSTLDDNVKI SQINSYSDHM DTVSQVLFHP
DGTCLISSSF DHKIKITDIR SNKLIQHYNA HDAQVNSISI HPTGYFLASA GSDSKIKIWD
LRQGRQIYTL YSNDKDITTV QFNQSGDYFA TGGSQNLCMV WKTNFDQNIQ NIEQVQRSTV
RQNDVEYSSG GLYAQTLFKT NKTASLSPSK KTISIIPPQQ LQDTFNNRGD DELNNGRVHE
NKQSNSPTFS QQQQQQQLNL SENQYPGLEI VGNQFNLQQS TLSNNNNQNN LIKSQNDSIV
SNKNAIPFHP SSEFQQSAVQ QQFSQQPKLV VNNGTATYPS NFVPKVEEEN IMTEAIAASM
QQIYSRLDTM FQYMTNLENR VVQSEQLQKS FVSQNHQNTL DPKQQTMNFG YSNIQDHSLS
ASLNDRNVVN IFQAGALANT GSIEASLINK QQEE
