ID   POC5_MACFA              Reviewed;         547 AA.
AC   Q4R8G4;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Centrosomal protein POC5;
DE   AltName: Full=Protein of centriole 5;
GN   Name=POC5; ORFNames=QtsA-12524;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential for the assembly of the distal half of centrioles,
CC       required for centriole elongation. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CETN2 and CETN3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000250}. Note=Localized to the
CC       distal portion of centrioles. {ECO:0000250}.
CC   -!- PTM: Hyperphosphorylated during recruitment to procentrioles in G2/M
CC       phase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the POC5 family. {ECO:0000305}.
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DR   EMBL; AB168488; BAE00608.1; -; mRNA.
DR   RefSeq; NP_001272092.1; NM_001285163.1.
DR   AlphaFoldDB; Q4R8G4; -.
DR   SMR; Q4R8G4; -.
DR   STRING; 9541.XP_005557250.1; -.
DR   GeneID; 101865441; -.
DR   CTD; 134359; -.
DR   eggNOG; ENOG502QUKU; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR033351; POC5.
DR   PANTHER; PTHR28618; PTHR28618; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cell cycle; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..547
FT                   /note="Centrosomal protein POC5"
FT                   /id="PRO_0000281909"
FT   REPEAT          114..145
FT                   /note="Centrin-binding (CBR) 1"
FT   REPEAT          203..234
FT                   /note="Centrin-binding (CBR) 2"
FT   REPEAT          235..267
FT                   /note="Centrin-binding (CBR) 3"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          347..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          509..547
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          163..189
FT                   /evidence="ECO:0000255"
FT   COILED          288..327
FT                   /evidence="ECO:0000255"
FT   MOD_RES         81
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NA72"
FT   MOD_RES         510
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NA72"
FT   MOD_RES         536
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NA72"
SQ   SEQUENCE   547 AA;  60028 MW;  EB47FCCFBD703887 CRC64;
     MSSDEEKYSL PVVQNDSSPG SSVSSNLQEE YEELLRYAIV TPNIEPGASQ SSHPKGELVP
     DVRISTIHDI LHSQESSPVL SPRKASHPVM DFFSSHLLAD SSSPATNSSH TDAHEILVGD
     FLVSDENLQK MENVLDLWSS GLKTNIISEL SKWRLNFIDW HRMEMRKEKE KHAAHLKQLC
     NQISDLKELQ KTFEISIGRK DEVISSLSHA IGKQKEKIEL MRTFFHWRIG HVRARQDVYE
     GKLADQYYQR TLLKKVWKGW RSVVQKQWKD VVERACQARA EEVCVQISND YEAKVAMLSG
     ALENAKAEIQ RMQHEKEHFE DSMKKAFMRG VCALNLEAMT IFQNRNDTGV DSTNNKKEEY
     GPGVQGKEHS AHLDPSAPPM PLPVASPLLP SPPAAVGGAS ATAVPSAASM TSTRAASASS
     AHVPVSVLGA GSAATAASEE MYVPRVVTSA QQKAGRTITA RITGRCDFAS KNRISSGLAI
     MGVSPPMSSV VVEKHHPVTV QTIPQATAAK YPRTIHPESS TSASRSLGTR SAHTPSLTSV
     QSIKVVD