POC5_MOUSE
ID POC5_MOUSE Reviewed; 558 AA.
AC Q9DBS8; Q8C299; Q8CI36; Q9CZ74;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Centrosomal protein POC5;
DE AltName: Full=Protein of centriole 5;
GN Name=Poc5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Bone marrow, Lung, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Eye, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Essential for the assembly of the distal half of centrioles,
CC required for centriole elongation. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CETN2 and CETN3. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriole {ECO:0000250}. Note=Localized to the
CC distal portion of centrioles. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9DBS8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9DBS8-2; Sequence=VSP_024101, VSP_024102;
CC -!- PTM: Hyperphosphorylated during recruitment to procentrioles in G2/M
CC phase. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the POC5 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB28553.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK004769; BAB23548.1; -; mRNA.
DR EMBL; AK012926; BAB28553.1; ALT_FRAME; mRNA.
DR EMBL; AK089013; BAC40701.1; -; mRNA.
DR EMBL; AK150656; BAE29743.1; -; mRNA.
DR EMBL; BC016527; AAH16527.1; -; mRNA.
DR EMBL; BC027118; AAH27118.1; -; mRNA.
DR EMBL; BC037631; AAH37631.1; -; mRNA.
DR CCDS; CCDS26703.1; -. [Q9DBS8-1]
DR RefSeq; NP_080449.1; NM_026173.3. [Q9DBS8-1]
DR AlphaFoldDB; Q9DBS8; -.
DR SMR; Q9DBS8; -.
DR IntAct; Q9DBS8; 2.
DR MINT; Q9DBS8; -.
DR STRING; 10090.ENSMUSP00000096898; -.
DR iPTMnet; Q9DBS8; -.
DR PhosphoSitePlus; Q9DBS8; -.
DR EPD; Q9DBS8; -.
DR MaxQB; Q9DBS8; -.
DR PaxDb; Q9DBS8; -.
DR PeptideAtlas; Q9DBS8; -.
DR PRIDE; Q9DBS8; -.
DR ProteomicsDB; 289356; -. [Q9DBS8-1]
DR ProteomicsDB; 289357; -. [Q9DBS8-2]
DR Antibodypedia; 49002; 111 antibodies from 17 providers.
DR Ensembl; ENSMUST00000099295; ENSMUSP00000096898; ENSMUSG00000021671. [Q9DBS8-1]
DR GeneID; 67463; -.
DR KEGG; mmu:67463; -.
DR UCSC; uc007rmv.2; mouse. [Q9DBS8-2]
DR UCSC; uc007rmw.2; mouse. [Q9DBS8-1]
DR CTD; 134359; -.
DR MGI; MGI:1914713; Poc5.
DR VEuPathDB; HostDB:ENSMUSG00000021671; -.
DR eggNOG; ENOG502QUKU; Eukaryota.
DR GeneTree; ENSGT00390000004454; -.
DR HOGENOM; CLU_035726_0_0_1; -.
DR InParanoid; Q9DBS8; -.
DR OMA; AMTMFQN; -.
DR OrthoDB; 1217267at2759; -.
DR PhylomeDB; Q9DBS8; -.
DR TreeFam; TF329296; -.
DR BioGRID-ORCS; 67463; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Poc5; mouse.
DR PRO; PR:Q9DBS8; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9DBS8; protein.
DR Bgee; ENSMUSG00000021671; Expressed in spermatocyte and 248 other tissues.
DR Genevisible; Q9DBS8; MM.
DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR InterPro; IPR033351; POC5.
DR PANTHER; PTHR28618; PTHR28618; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Alternative splicing; Cell cycle; Coiled coil; Cytoplasm;
KW Cytoskeleton; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..558
FT /note="Centrosomal protein POC5"
FT /id="PRO_0000281910"
FT REPEAT 126..157
FT /note="Centrin-binding (CBR) 1"
FT REPEAT 215..246
FT /note="Centrin-binding (CBR) 2"
FT REPEAT 247..279
FT /note="Centrin-binding (CBR) 3"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 175..209
FT /evidence="ECO:0000255"
FT COILED 300..340
FT /evidence="ECO:0000255"
FT COMPBIAS 80..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 23
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q4V891"
FT MOD_RES 81
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4V891"
FT MOD_RES 93
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8NA72"
FT MOD_RES 522
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q8NA72"
FT MOD_RES 548
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8NA72"
FT VAR_SEQ 216..223
FT /note="ISNLSRAI -> LFSLPPLE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024101"
FT VAR_SEQ 224..558
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024102"
FT CONFLICT 111
FT /note="G -> D (in Ref. 2; AAH16527/AAH37631)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 558 AA; 60956 MW; 20178C21920F0FA1 CRC64;
MSSDEDKCSL HVAHNDSDRS VSTDLQEEYE ELLRYAIVNP NVECSASQPS HLRGEVAPDR
FPTLAGNNPV RDTELEVGKG SDLNISSHSK SGSPRKPSHP VMDFFSSHVL GDSSSPASLS
TRTDAHEING GEHLVSDENF QKLENILDIW SSGLKTNVLS ELSKWRLNFI DWHRMEMKKE
KEKHAVVVKQ LSNQISDLKE LQKAFEISIG RKDEVISNLS RAIGKQKERI ELMKSFFRWR
IGHVKSRQEI YEGKLADQYF QRTLLKKVWK GWRSVVQRQW KDVVERACQA RAEEVCVQIS
NDYEARLAML SGALENAKAE IQKMQQEKDH FEDSMKKAFM RGVCALNLEA MTIFQNKNEA
GIDFTNNKKE ESGPGGPGRE PSAHLDTSSS TMPSAVPSQL LPSGPLAAGV ASATAFPSAA
SLTSAGATSA SSLHVPISIL SAGSAAAPAP EESYAPRVVT AAQQKAGKTI TARITGRSDF
GSKARINSSL AIMGVSPPMG SVVVEKHHPV TVQTIPQATA AKYPRTIHPE SSISASRSLG
ARPGHAQSLS VQSIKVVD
