ID   POC5_RAT                Reviewed;         558 AA.
AC   Q4V891;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Centrosomal protein POC5;
DE   AltName: Full=Protein of centriole 5;
GN   Name=Poc5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-23 AND SER-80, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Essential for the assembly of the distal half of centrioles,
CC       required for centriole elongation. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CETN2 and CETN3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000250}. Note=Localized to the
CC       distal portion of centrioles. {ECO:0000250}.
CC   -!- PTM: Hyperphosphorylated during recruitment to procentrioles in G2/M
CC       phase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the POC5 family. {ECO:0000305}.
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DR   EMBL; BC097489; AAH97489.1; -; mRNA.
DR   RefSeq; NP_001020818.1; NM_001025647.1.
DR   RefSeq; XP_006231883.1; XM_006231821.2.
DR   AlphaFoldDB; Q4V891; -.
DR   SMR; Q4V891; -.
DR   STRING; 10116.ENSRNOP00000058225; -.
DR   iPTMnet; Q4V891; -.
DR   PhosphoSitePlus; Q4V891; -.
DR   PaxDb; Q4V891; -.
DR   PRIDE; Q4V891; -.
DR   Ensembl; ENSRNOT00000087418; ENSRNOP00000070872; ENSRNOG00000018193.
DR   GeneID; 294667; -.
DR   KEGG; rno:294667; -.
DR   UCSC; RGD:1310597; rat.
DR   CTD; 134359; -.
DR   RGD; 1310597; Poc5.
DR   eggNOG; ENOG502QUKU; Eukaryota.
DR   GeneTree; ENSGT00390000004454; -.
DR   InParanoid; Q4V891; -.
DR   OrthoDB; 1217267at2759; -.
DR   PhylomeDB; Q4V891; -.
DR   PRO; PR:Q4V891; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000018193; Expressed in testis and 19 other tissues.
DR   ExpressionAtlas; Q4V891; baseline and differential.
DR   Genevisible; Q4V891; RN.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005813; C:centrosome; ISO:RGD.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR033351; POC5.
DR   PANTHER; PTHR28618; PTHR28618; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cell cycle; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..558
FT                   /note="Centrosomal protein POC5"
FT                   /id="PRO_0000281911"
FT   REPEAT          125..156
FT                   /note="Centrin-binding (CBR) 1"
FT   REPEAT          214..245
FT                   /note="Centrin-binding (CBR) 2"
FT   REPEAT          246..278
FT                   /note="Centrin-binding (CBR) 3"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          360..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          174..199
FT                   /evidence="ECO:0000255"
FT   COILED          299..337
FT                   /evidence="ECO:0000255"
FT   MOD_RES         23
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         80
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         92
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NA72"
FT   MOD_RES         521
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NA72"
FT   MOD_RES         547
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NA72"
SQ   SEQUENCE   558 AA;  60995 MW;  FF843F5DF1E9AE24 CRC64;
     MSSDEDKCSL HVAHNDSDRS VSTDLQEEYE ELLRYAVVNP NVESGVSRPS HLRGEAVPDR
     FPVLGSNPLR ETALEVGKGS DLNISSLSKS GSPRKPPHPV MDFFGPHFLG DSSSPASIST
     RTDAHEIIVG DHLVSEENFQ KLENVLDIWS SGLKTNILSE LSKWRLNFID WHRMEMKKER
     EKHAVTVKQL SSQIADLKEL QKAFEISIGR KDEVISSLSR AIGKQKERIE LMKSFFRWRI
     GHVKSRQESY EGKLADQYFE RTLLKKVWKG WRSVVQRQWK DVVERACQAR AEEVCVQISN
     DYEAKLAMLS LALENAKAEI QRMHQEKDHF EDSMKKAFMR GVCALNLEAM TIFQNKNDAG
     IDFTNNKKEE SGPGGPGREP SAHLDTSSST MPSAVPLQLL PSATLAAGVA SATAIPSTAS
     LTSAGATSAS SGHVPISVLS AGSAATAAPE DTFAPRVVTA AQQKAGKTIT ARITGRCDFG
     SKTRINSSLA IMGVSPPMSS VVVEKHHPVT VQTIPQATAA KYPRAIHPES GFPASRSVGA
     RPAHAQSLSN VQSIKVVD