PODJ_CAUVN
ID PODJ_CAUVN Reviewed; 974 AA.
AC B8GXA0;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Localization factor PodJL;
DE AltName: Full=Polar organelle development protein;
DE Contains:
DE RecName: Full=Localization factor PodJS;
GN Name=podJ; OrderedLocusNames=CCNA_02125;
OS Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=565050;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA1000 / CB15N;
RX PubMed=20472802; DOI=10.1128/jb.00255-10;
RA Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA Walunas T.L., Crosson S.;
RT "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL J. Bacteriol. 192:3678-3688(2010).
RN [2]
RP FUNCTION.
RX PubMed=12370432; DOI=10.1073/pnas.182411999;
RA Viollier P.H., Sternheim N., Shapiro L.;
RT "Identification of a localization factor for the polar positioning of
RT bacterial structural and regulatory proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:13831-13836(2002).
CC -!- FUNCTION: PodJL provides the positional information for the
CC localization of several polar organelles (pili, adhesive holdfast and
CC chemotactic apparatus) by recruiting structural (CpaE) and regulatory
CC (PleC) proteins to a specific cell pole. {ECO:0000269|PubMed:12370432}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein. Note=Both
CC PodJL and PodJS localize to the swarmer pole at different stages of the
CC cell division.
CC -!- DEVELOPMENTAL STAGE: PodJS, from the previous progeny, accumulates in
CC the swarmer cell, and is partially degraded during the swarmer-to-
CC stalked transition by sequential proteolytic cleavages (MmpA). PodJL,
CC from the new progeny, is synthesized in the early predivisional cell,
CC and then is likely to be converted to PodJS by proteolytic cleavage of
CC periplasmic domain. After cell division, PodJL disappears, while the
CC level of PodJS increases in the swarmer cell progeny.
CC -!- PTM: Two isoforms exist, the full-length translation product PodJL and
CC a C-terminal truncated form PodJS. Both appear during a specific time
CC period of the cell cycle to control different aspects of polar
CC organelle development.
CC -!- MISCELLANEOUS: PodJS must be degraded to preserve the asymmetry of the
CC next cell cycle.
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DR EMBL; CP001340; ACL95590.1; -; Genomic_DNA.
DR RefSeq; WP_012640394.1; NC_011916.1.
DR RefSeq; YP_002517498.1; NC_011916.1.
DR AlphaFoldDB; B8GXA0; -.
DR SMR; B8GXA0; -.
DR PRIDE; B8GXA0; -.
DR EnsemblBacteria; ACL95590; ACL95590; CCNA_02125.
DR GeneID; 7330431; -.
DR KEGG; ccs:CCNA_02125; -.
DR PATRIC; fig|565050.3.peg.2082; -.
DR HOGENOM; CLU_300301_0_0_5; -.
DR OMA; ITEAMPR; -.
DR OrthoDB; 166467at2; -.
DR Proteomes; UP000001364; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 1.10.101.10; -; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR002477; Peptidoglycan-bd-like.
DR InterPro; IPR036365; PGBD-like_sf.
DR InterPro; IPR036366; PGBDSf.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR Pfam; PF01471; PG_binding_1; 1.
DR Pfam; PF08238; Sel1; 3.
DR SMART; SM00671; SEL1; 3.
DR SUPFAM; SSF47090; SSF47090; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Coiled coil; Differentiation; Membrane;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..974
FT /note="Localization factor PodJL"
FT /id="PRO_0000378600"
FT CHAIN 1..?
FT /note="Localization factor PodJS"
FT /id="PRO_0000378601"
FT TRANSMEM 642..662
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 757..793
FT /note="Sel1-like 1"
FT REPEAT 794..829
FT /note="Sel1-like 2"
FT REPEAT 830..865
FT /note="Sel1-like 3"
FT REGION 460..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 81..163
FT /evidence="ECO:0000255"
FT COILED 218..320
FT /evidence="ECO:0000255"
FT COILED 375..469
FT /evidence="ECO:0000255"
FT COMPBIAS 468..488
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 974 AA; 103491 MW; BB85D8DCEE9EE0B7 CRC64;
MTAASPWSVK GIDPKAREVA KDLARRSGMT LGEWLNRMII EGDGQTADPR LAGDDVPNRA
YLEIVKDDAP PRIEIAEHPA DEVGRVALAL DRLTQRIEAA EGRNAAAITG IDHSVRDALT
RLGASEREQI AVAARFEGAV DELKTEQARA TERLRRIESE AAGPRSAEAL RALEGALGKV
AGHLYEGEAR TREAIATLEA KLNQQSSGDP SALVEAVVAR LGERLEAAET RTSDALRELG
ASFQALDQRL GAVETANPAT GVQEGLDSLA ATLTQKMEAA RLEMAAKLRE SADGRFDRME
RKLGEMAAHV QAAEQRSAQA IERMGREIVG VADAFNRRVH AAESRNASAI EQVGGEVARI
AASVEHKLNR ADSVQAQALE KLGGEIARIT EKLAERIGSA ERRNALAIDD VGEQVARVTE
RLNQRHERSS QELVDRIRQS EERTLRMLEE AREKIDSRLS EAQRKLEAAP PSPPPAQAPA
PVATAQRPVP PAASPFEDNY FSQAASFSTS EDEADAFDAP PAPARSFEVA EFPAAEPEEP
AFAHDDYAIA DGFEPESPRY EVEPEVSDFA PAEPSRPMST RDIIEQARAA ARAAAASEGK
GGKAKSAKKE KASKASGSLF SGFGGFSTKK SKARLGATVT TALVVFAAAG ALGAGVGGLL
LLNTDDGNNS PSRVAQAIAG RKADVEVNGP EADTTPGAPR AAVALTTGKV VPAEVEAPAA
PPTNEAKALF EDAVRKIESG DRSGVELLKR AANGGYPAAQ FYLSKMYEGG KNGVKVDMAE
ARRWSERAAN GGDPRAMHNL ALYYFKGEGG PRNSTTAASW FRKAADMGLV DSQFNLAQLY
ESGLGVSQNP AEAYKWYVIA GRAGDSTARG RATALRSQLT AEAQQTADRS ALAFRPQTQV
QTASLSSAAP AAANANLGVA QRVLSQLGYY QGPRDGVSSP ALRMAIAAYQ RDQGLPPTGS
VDAETLNRLS VYAR
