PODN_HUMAN
ID PODN_HUMAN Reviewed; 613 AA.
AC Q7Z5L7; B4DKN5; B4E373; Q5VVZ2; Q5VVZ3; Q6PIR3; Q6UXL8; Q8N641;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2006, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Podocan;
DE Flags: Precursor;
GN Name=PODN; Synonyms=SLRR5A; ORFNames=UNQ293/PRO332;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND VARIANTS
RP MET-444 AND ALA-472.
RC TISSUE=Kidney;
RX PubMed=12796502; DOI=10.1074/jbc.m301299200;
RA Ross M.D., Bruggeman L.A., Hanss B., Sunamoto M., Marras D., Klotman M.E.,
RA Klotman P.E.;
RT "Podocan, a novel small leucine-rich repeat protein expressed in the
RT sclerotic glomerular lesion of experimental HIV-associated nephropathy.";
RL J. Biol. Chem. 278:33248-33255(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT ALA-472.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), AND VARIANT
RP ALA-472.
RC TISSUE=Colon, Tongue, and Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT ALA-472.
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION, AND
RP INTERACTION WITH TYPE I COLLAGEN.
RX PubMed=15063725; DOI=10.1016/s0014-5793(04)00250-9;
RA Shimizu-Hirota R., Sasamura H., Kuroda M., Kobayashi E., Saruta T.;
RT "Functional characterization of podocan, a member of a new class in the
RT small leucine-rich repeat protein family.";
RL FEBS Lett. 563:69-74(2004).
RN [7]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-281 AND ASN-299.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of multiple
RT enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
RN [8]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=20551380; DOI=10.1074/mcp.m110.001693;
RA Didangelos A., Yin X., Mandal K., Baumert M., Jahangiri M., Mayr M.;
RT "Proteomics characterization of extracellular space components in the human
RT aorta.";
RL Mol. Cell. Proteomics 9:2048-2062(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: Negatively regulates cell proliferation and cell migration.
CC {ECO:0000269|PubMed:15063725}.
CC -!- SUBUNIT: Binds to type I collagen.
CC -!- INTERACTION:
CC Q7Z5L7-3; Q86X45: DNAAF11; NbExp=3; IntAct=EBI-23806733, EBI-9379658;
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Secreted, extracellular space,
CC extracellular matrix.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q7Z5L7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z5L7-2; Sequence=VSP_037827;
CC Name=3;
CC IsoId=Q7Z5L7-3; Sequence=VSP_021784;
CC Name=4;
CC IsoId=Q7Z5L7-4; Sequence=VSP_021784, VSP_039064;
CC -!- TISSUE SPECIFICITY: Kidney, heart, liver, pancreas and vascular smooth
CC muscle cells. Also detected in aortic intima (at protein level).
CC {ECO:0000269|PubMed:12796502, ECO:0000269|PubMed:15063725,
CC ECO:0000269|PubMed:20551380}.
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:15063725,
CC ECO:0000269|PubMed:19159218}.
CC -!- MISCELLANEOUS: [Isoform 2]: No signal peptide. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 3]: No signal peptide. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 4]: No signal peptide. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC family. SLRP class V subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH28292.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY313607; AAP79898.1; -; mRNA.
DR EMBL; AY358294; AAQ88661.1; -; mRNA.
DR EMBL; AK296649; BAG59247.1; -; mRNA.
DR EMBL; AK299375; BAG61365.1; -; mRNA.
DR EMBL; AK304599; BAG65385.1; -; mRNA.
DR EMBL; AL445183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC028292; AAH28292.1; ALT_INIT; mRNA.
DR EMBL; BC030608; AAH30608.1; -; mRNA.
DR CCDS; CCDS55602.1; -. [Q7Z5L7-1]
DR CCDS; CCDS573.1; -. [Q7Z5L7-1]
DR RefSeq; NP_001186009.1; NM_001199080.2. [Q7Z5L7-1]
DR RefSeq; NP_001186010.1; NM_001199081.2. [Q7Z5L7-1]
DR RefSeq; NP_714914.2; NM_153703.4. [Q7Z5L7-1]
DR RefSeq; XP_005270514.1; XM_005270457.3. [Q7Z5L7-1]
DR AlphaFoldDB; Q7Z5L7; -.
DR SMR; Q7Z5L7; -.
DR BioGRID; 126059; 21.
DR IntAct; Q7Z5L7; 8.
DR STRING; 9606.ENSP00000308315; -.
DR GlyConnect; 1618; 7 N-Linked glycans (2 sites).
DR GlyGen; Q7Z5L7; 4 sites, 6 N-linked glycans (2 sites).
DR iPTMnet; Q7Z5L7; -.
DR PhosphoSitePlus; Q7Z5L7; -.
DR BioMuta; PODN; -.
DR DMDM; 118573110; -.
DR EPD; Q7Z5L7; -.
DR jPOST; Q7Z5L7; -.
DR MassIVE; Q7Z5L7; -.
DR PaxDb; Q7Z5L7; -.
DR PeptideAtlas; Q7Z5L7; -.
DR PRIDE; Q7Z5L7; -.
DR ProteomicsDB; 69321; -. [Q7Z5L7-1]
DR ProteomicsDB; 69322; -. [Q7Z5L7-2]
DR ProteomicsDB; 69323; -. [Q7Z5L7-3]
DR ProteomicsDB; 69324; -. [Q7Z5L7-4]
DR Antibodypedia; 2151; 122 antibodies from 28 providers.
DR DNASU; 127435; -.
DR Ensembl; ENST00000312553.10; ENSP00000308315.6; ENSG00000174348.14. [Q7Z5L7-1]
DR Ensembl; ENST00000371500.8; ENSP00000360555.3; ENSG00000174348.14. [Q7Z5L7-2]
DR Ensembl; ENST00000395871.7; ENSP00000379212.3; ENSG00000174348.14. [Q7Z5L7-3]
DR Ensembl; ENST00000618387.1; ENSP00000479233.1; ENSG00000174348.14. [Q7Z5L7-2]
DR GeneID; 127435; -.
DR KEGG; hsa:127435; -.
DR MANE-Select; ENST00000312553.10; ENSP00000308315.6; NM_153703.5; NP_714914.3.
DR UCSC; uc001cuv.4; human. [Q7Z5L7-1]
DR CTD; 127435; -.
DR DisGeNET; 127435; -.
DR GeneCards; PODN; -.
DR HGNC; HGNC:23174; PODN.
DR HPA; ENSG00000174348; Low tissue specificity.
DR MIM; 608661; gene.
DR neXtProt; NX_Q7Z5L7; -.
DR OpenTargets; ENSG00000174348; -.
DR PharmGKB; PA134980106; -.
DR VEuPathDB; HostDB:ENSG00000174348; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000160740; -.
DR HOGENOM; CLU_000288_186_3_1; -.
DR InParanoid; Q7Z5L7; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; Q7Z5L7; -.
DR TreeFam; TF336377; -.
DR PathwayCommons; Q7Z5L7; -.
DR SignaLink; Q7Z5L7; -.
DR BioGRID-ORCS; 127435; 12 hits in 1069 CRISPR screens.
DR ChiTaRS; PODN; human.
DR GenomeRNAi; 127435; -.
DR Pharos; Q7Z5L7; Tbio.
DR PRO; PR:Q7Z5L7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q7Z5L7; protein.
DR Bgee; ENSG00000174348; Expressed in right ovary and 136 other tissues.
DR ExpressionAtlas; Q7Z5L7; baseline and differential.
DR Genevisible; Q7Z5L7; HS.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0005518; F:collagen binding; IDA:UniProtKB.
DR GO; GO:0030336; P:negative regulation of cell migration; IDA:UniProtKB.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:UniProtKB.
DR Gene3D; 3.80.10.10; -; 5.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR026906; LRR_5.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF13306; LRR_5; 1.
DR Pfam; PF13855; LRR_8; 4.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00013; LRRNT; 1.
DR PROSITE; PS51450; LRR; 17.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Extracellular matrix; Glycoprotein;
KW Leucine-rich repeat; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..613
FT /note="Podocan"
FT /id="PRO_0000262524"
FT DOMAIN 59..96
FT /note="LRRNT"
FT REPEAT 97..118
FT /note="LRR 1"
FT REPEAT 121..141
FT /note="LRR 2"
FT REPEAT 147..168
FT /note="LRR 3"
FT REPEAT 169..189
FT /note="LRR 4"
FT REPEAT 192..212
FT /note="LRR 5"
FT REPEAT 218..238
FT /note="LRR 6"
FT REPEAT 239..260
FT /note="LRR 7"
FT REPEAT 263..283
FT /note="LRR 8"
FT REPEAT 289..310
FT /note="LRR 9"
FT REPEAT 311..331
FT /note="LRR 10"
FT REPEAT 334..357
FT /note="LRR 11"
FT REPEAT 360..380
FT /note="LRR 12"
FT REPEAT 381..402
FT /note="LRR 13"
FT REPEAT 405..426
FT /note="LRR 14"
FT REPEAT 431..452
FT /note="LRR 15"
FT REPEAT 476..489
FT /note="LRR 16"
FT REPEAT 502..522
FT /note="LRR 17"
FT REPEAT 523..544
FT /note="LRR 18"
FT REPEAT 547..568
FT /note="LRR 19"
FT REPEAT 573..595
FT /note="LRR 20"
FT REGION 588..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 214
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 281
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19159218"
FT CARBOHYD 299
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19159218"
FT CARBOHYD 410
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1
FT /note="M -> MEGEEAEQPAWFRQPWRPGASDSAPPAGTM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_037827"
FT VAR_SEQ 1
FT /note="M -> MEGARARGAQLRLGERVRPVGRRSAPGRSRFRQPWRPGASDSAPPAG
FT TM (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_021784"
FT VAR_SEQ 105..246
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039064"
FT VARIANT 444
FT /note="T -> M (in dbSNP:rs12567021)"
FT /evidence="ECO:0000269|PubMed:12796502"
FT /id="VAR_029497"
FT VARIANT 472
FT /note="V -> A (in dbSNP:rs1288389)"
FT /evidence="ECO:0000269|PubMed:12796502,
FT ECO:0000269|PubMed:12975309, ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_029498"
FT CONFLICT Q7Z5L7-3:32
FT /note="R -> H (in Ref. 5; AAH30608)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 613 AA; 68976 MW; DA574FC77CCDAC91 CRC64;
MAQSRVLLLL LLLPPQLHLG PVLAVRAPGF GRSGGHSLSP EENEFAEEEP VLVLSPEEPG
PGPAAVSCPR DCACSQEGVV DCGGIDLREF PGDLPEHTNH LSLQNNQLEK IYPEELSRLH
RLETLNLQNN RLTSRGLPEK AFEHLTNLNY LYLANNKLTL APRFLPNALI SVDFAANYLT
KIYGLTFGQK PNLRSVYLHN NKLADAGLPD NMFNGSSNVE VLILSSNFLR HVPKHLPPAL
YKLHLKNNKL EKIPPGAFSE LSSLRELYLQ NNYLTDEGLD NETFWKLSSL EYLDLSSNNL
SRVPAGLPRS LVLLHLEKNA IRSVDANVLT PIRSLEYLLL HSNQLREQGI HPLAFQGLKR
LHTVHLYNNA LERVPSGLPR RVRTLMILHN QITGIGREDF ATTYFLEELN LSYNRITSPQ
VHRDAFRKLR LLRSLDLSGN RLHTLPPGLP RNVHVLKVKR NELAALARGA LVGMAQLREL
YLTSNRLRSR ALGPRAWVDL AHLQLLDIAG NQLTEIPEGL PESLEYLYLQ NNKISAVPAN
AFDSTPNLKG IFLRFNKLAV GSVVDSAFRR LKHLQVLDIE GNLEFGDISK DRGRLGKEKE
EEEEEEEEEE ETR