ID   POE_DROPS               Reviewed;        5381 AA.
AC   Q29L39;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Protein purity of essence;
GN   Name=poe {ECO:0000250|UniProtKB:Q9VLT5}; ORFNames=GA13010;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1] {ECO:0000312|EMBL:EAL32985.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Has a role in growth of the perineurial glial layer of the
CC       larval peripheral nerve. May have a role in male fertility and eye
CC       development or function. May bind calmodulin (By similarity).
CC       {ECO:0000250|UniProtKB:Q9VLT5}.
CC   -!- SIMILARITY: Belongs to the UBR4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL32985.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH379061; EAL32985.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001355926.1; XM_001355890.3.
DR   STRING; 7237.FBpp0287714; -.
DR   PRIDE; Q29L39; -.
DR   EnsemblMetazoa; FBtr0289276; FBpp0287714; FBgn0073048.
DR   GeneID; 4816331; -.
DR   KEGG; dpo:Dpse_GA13010; -.
DR   eggNOG; KOG1776; Eukaryota.
DR   HOGENOM; CLU_000069_0_0_1; -.
DR   InParanoid; Q29L39; -.
DR   OMA; NAEACMH; -.
DR   PhylomeDB; Q29L39; -.
DR   Proteomes; UP000001819; Chromosome 4.
DR   Bgee; FBgn0073048; Expressed in adult organism and 3 other tissues.
DR   GO; GO:0043186; C:P granule; IEA:EnsemblMetazoa.
DR   GO; GO:0005516; F:calmodulin binding; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:EnsemblMetazoa.
DR   GO; GO:0042066; P:perineurial glial growth; IEA:EnsemblMetazoa.
DR   GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:EnsemblMetazoa.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007291; P:sperm individualization; ISS:UniProtKB.
DR   GO; GO:0007286; P:spermatid development; ISS:UniProtKB.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR025704; E3_Ub_ligase_UBR4_C.
DR   InterPro; IPR045841; E3_UBR4_N.
DR   InterPro; IPR045189; UBR4-like.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR003126; Znf_UBR.
DR   PANTHER; PTHR21725; PTHR21725; 1.
DR   Pfam; PF13764; E3_UbLigase_R4; 1.
DR   Pfam; PF19423; E3_UBR4_N; 4.
DR   Pfam; PF02207; zf-UBR; 1.
DR   SMART; SM00396; ZnF_UBR1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS51157; ZF_UBR; 1.
PE   3: Inferred from homology;
KW   Calmodulin-binding; Developmental protein; Differentiation; Metal-binding;
KW   Neurogenesis; Reference proteome; Sensory transduction; Vision; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..5381
FT                   /note="Protein purity of essence"
FT                   /id="PRO_0000245795"
FT   ZN_FING         1815..1884
FT                   /note="UBR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00508"
FT   REGION          140..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          339..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          599..621
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          683..709
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1162..1212
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1632..1659
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1917..1939
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2443..2479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2632..2652
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3037..3143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3537..3562
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4247..4280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        140..163
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        339..361
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1163..1181
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1186..1209
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1917..1935
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3037..3103
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3537..3551
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4247..4272
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   5381 AA;  596641 MW;  04179216FA0DE9C0 CRC64;
     MSSHSGGTDW NSVIKALLLS RTGALNKNEV VNLLKAITRC EHEFFDDEGS FVPFYTAFAA
     LAADKLMQIK SICQTQICQL HDATAVLIRF ILFRLPKVSV FESKWLLAAL KMLCEGRENA
     SSAVAQFDYS AVAGVVKSSK HPESSNKSIM SMAGSTTGGA GAGGSNDKES PKLEIKRSRS
     DLSSVILQQL LAPLEPGKMT WVPLSEEITD CTEQLLAANV EVFQEANGVD TLLDICVGLP
     ILSRYRMKYM ETINAGKPLY LPLTQAEATT VKSSMNHMLT DLSIVGQAYA LIVMQPLTPS
     RIEKLSMCGI SALYNAVLTS IATSVLSMGQ ASSAQKQQQQ QTAAAASTSQ GSGGGLSSVQ
     TSKDHDEFEE QASGIVNKAL EIYSSIGEMF KSSARMYIYQ NHLCYGSWLL ISGIQGAMGA
     SGSASAETAA KAAAATKVAS KTESITAPST PIARVNLFKV QQGFGELNAA IANHSIKLLS
     ELIEDLKIES ACGQSSVTDP ETLPEPAQFD ILQNYTSLER IVRVLNTATL HQLFTFLATV
     AYRKACTLKR ASTKDRTECD PISYSDSTTC LNESMSYSDN SEEDDSESYL GHWFKETLSP
     ETHDDNANTS SQERSGEQKS ALVPKLDEPH EYLELSADIF CFLDQFLANR HAYMQRYVKA
     GVSDQQMLLM ANIIKDFDRD VMRNDSEQQS PPSTAAAVAA ATGAGSSGSS AKWQASMIRF
     SGAAGRYIHN LISTGLLSEQ LQSNLLQHLA ISPWSTDTNT WPLQVYPSTL SVLVQILLLK
     PIQEKEAACL SVWHRLINTL VDGVCSSSSA GDSDYEDINI EHAQLLLFLF HSLNLMQKKS
     ILLLTAGGVI RCAEVCRGIS AERVVRNSQM MLLSRLLVFL EYLMKHLYHA PPELLDQVRW
     ILFSVSSMPE TQKVSDLINS RTKLNSYCRQ DIEEKFRKSS GEYGSNIRPT FYSLVVKEPE
     KAYWVSEFKL DGLAWNFILC TPDKLKYPLL VDALVDILNI ADMSSFSRKE NSESNSIHNL
     CAMQYCFTNT WKLLLGLPPS TSHVEALRIE RAPNLHSLVW STRLPLATSH YLIVNSLIKQ
     GMYTQYAESL YTQVGDTTAD IRYNLKQTIL GVEAFNQQMS NKGIPRLSEL ILFDALVAHM
     QAVAWAEKEG FKLLRKDCED SSGGDQSSCT SAASSSGGNA TDHDHPEVYS SNESIDEEKS
     KHEDDQGLST ETLQRNQMIN ELLIKLMDSY RYLSEIVREQ MLKQLSSTTP EHVLNLIVPI
     VSDKPAIMLE LHAAFLKLLP NEDKQLIANE WPKCLMVNDS AFDGKQHPVE PYTLNVIDAH
     ITELTRGSGG VAYSTLHTLK HCLKTILHLM ELLLPYASNC TEMDAQLKPL LIASMLDMRT
     DYLQGQSEQC LREILSGLTL EAQKLLLYEH MIGYCYRMLI EFAAELRQPA AGGTPLDQER
     ALFNESMLFA VLKTFIKMLE KPTAVQAMRQ FFHDQKTGSL TTLLLSFTGT TLPLSYARKM
     LQFVERLFEQ STRADSQFQH EDLVDCFSDL ATVDVARLKL WLAHIIYGPN MTAGDVSNSE
     TMDPTCRLLT SIMQPSSSSS SNAQTPTNMA TVSAMPSISD QLDAMDIDYD CGAAAGAAGA
     APNTSQILSL WQAAQPNPSE ESSQACDHSE GGEQRQSERN GGLLLSITKY LVRDQSKAGP
     IAAPLFQALL QLGQTLISPP HDGCDFADVL QIMITLADAS PARGHVALFN TTLLWLELAK
     LQLPDKHLRH AENVSALLRY LSELLQSIGY RGSRQHMPPW DDELQTDIDD LYDELAEEEQ
     DSLLDDSDED TLNNKLCTFS QTQKEFMNQH WYHCHTCNMI NTVGVCSVCA RVCHKGHDVS
     YAKYGNFFCD CGAKEDGSCQ ALSRRLGSGE VRESVGPGGS SSCSYLPSHM SLLASKKRSN
     TAPGATQQQH GAPARKDSIS SERIQLLGKL LEPYRETLQH QEQWMLVVRC ILEYFDVLLP
     SIRENCTLYS IVGCHRRATA ALQRLHQLEQ SFQITDQLMF ATLGSQEGAF ENVRMNYSGD
     QGQTIKHLLT SGTIRRVAFC CLSSPHGRRQ QLAVSHEKGK VTILQLSALL KQADASKRKL
     TLTQLSSAPI ACTVLSLAAN PCNEDCLAVC GLKECHVLTF SSSGSTNEHI VITPQLENGN
     FLKKAMWLPG SQTLLAIVTT DYVKIYDLSV DTISPKYYYL VAVGKIKDCT FMYHQQDGSG
     SYFMLSFTSS GYIYTQQLDQ QSLAVHGDFY VTNTLELSHQ HIKDINGQVC GGGVSIYYSH
     ALQLLFYSYT CGRSFCSPLT NVNEGVKGIY HLDINNTAAS TASKSSSASK VPLQSLVGWT
     EVAGHPGLIY ASMHTSNNPV ILMITPERIY MQEIKAQSAK SRIMDVVGIR HSVAGTEKTT
     LLLLCEDGSL RIFSAQPEHT SFWLSPQVQP FGNQLYSSTL LAKNTTNNPQ GKSKGGGSAA
     AGKLLHRKAS SQQHQKQLTS GGQPIFPIDF FEHCNMLADV EFGGNDLLQI YNKQKLKTRL
     FSTGMFVAST KATGFTLEVV NNDPNVVMVG FRVMLGTQDI QRAPVSVTIL GRTIPTTMRK
     ARWFDIPLTR EEMFQSDKML KVVFAKSQDP EHVTLLDSIE VYGKSKELVG WPDDSEDVPA
     PSSGPTPVTA TQQSAAANFG EGFNCITQLD RMVNHLLEVL DCALHLLGGS AVAAPLRSKV
     VKTASGLLLL PTPNPVQTQA RYVLATLYGS RAAYHSFKDG VILHFVHGEL QAMQPKLQQL
     ESLQEIDPEA FYRLILLVRG VANSRPQSLA KICLENSYDL VPDLMRIVLE LHKITPDLDE
     PVNIVRRGLC QPETIVHCLV EIMYGFALAD PGQVGRMTQY FIDLLKHDAT VISHSAKEAL
     ILLLSPRMKR RKVAAIAVIT PPACSTPTPQ MQALQAVAAS AANDIIEEAA GVAAGQDQDN
     AAAALLEAVE GGLPGQQANH QLLNLEAFMG GGFPRLLGLP EDGDDEAIMD IAIALSLQQH
     GGADANALHS LQQGLANIQG IRQAAANAAA ASVSVSVSAG GSDDEGSNVA TDGSTLRTSP
     AEPAGSGGSE SGGSGVESIG GTSARSSNFG DHPNTTPPRQ SCSSVKDGEP GEEQQPGPSG
     SGGSASVPGG GLSAMSSTED NNEINEDEKL QKLHDLRIAV LESIIQHLGT FDLCNGLQAI
     PLIQVIHMLT TDLNGNNERD QQVLQELLQA LVEYVEIGKR GAASRMENKC PGNEVRLALL
     SLFGVMMGKT KSKQTGTTSP PHQFKDNSSF VASTTANVLS KSGAFVYALE ALNTLLVHWK
     TVLGDPYAPG QAAAPIASGG ATSGPGVQLL KPVKHGPKPD ISILIPQNYL KNYPDIFESY
     DGLLTEIIVR LPYQILRLSS AHPDNYDSSF CEAMTFTLCE YMMLNLNTLL RRQVRKLLMY
     ICGSKEKFRM YRDGHSLDAH FRVVKRVCSI VSSKTGAPYN ANPPMLSYDS LVDLTEHLRT
     CQEISQMRTG NWQKFCVVHE DALAMLMEIA CYQLDDGVSP IIIQLLQAAV CNMPANKQQQ
     QQQQPPPAVV SASSKLRSDR EKSEDTDAYY SKFDPAQCGT FVHQIFRYAC DALIIRFVRI
     FLLENNISQL RWQAHSFMTG LFEHANERQR EKLLTIFWNL WPLVPTYGRR TAQFVDLLGY
     LTLTTRSITE RLPEFVSRAV EVLRTQNELL CKHPNAPVYT TLESILQMNG YYLESEPCLV
     CNNPEVPMAN IKLPSVKSDS KYTTTTMIYK LVQCHTISKL IVRIADLKRT KMVRTINVYY
     NNRSVQAVVE LKNRPALWHK ARSVSLQSGQ TELKIDFPLP ITACNLMIEF ADFFETVSGS
     SENLQCPRCS AAVPAYPGVC GNCGENVFQC HKCRAINYDE KDPFLCHSCG FCKYAKFDFS
     MYARVCCAVD PIESAEDRAK TVLMIHTSLE RADRIYHQLL ANKQLLELLI QKVAEHRIND
     RLVEDNMASV HSTSQVNKII QLLAQKYCVE SRASFEELSK IVQKVKACRS ELVAYDRQQQ
     DLPPSNLALV LGAENPTTNR CYGCALASTE QCLTLLRAMA YNYDCRMGLY SQGLVSELAE
     HNLRRGTPQI QNEVRNLLVV LTKDNAEACM HLLQLVTSRV KSALMGSIPL ISLEAAVHQE
     MTLLEVLLSQ DDLCWEYKLK VIFELFISNC KLPRGPVASV LHPCLRILQS LINPTISGSG
     SGGKPVSAIE LSNIKLPEGN TIDYRAWLNS DQNHEYLAWS SRMPISHHQQ DAPAGTKPKS
     SKQQQSAGTE TPPRKSKEAA RAAYLGEKFG KRWRSNVLDK QRVTKPLVFN AEWIQPLLFN
     ENSRFGRQLA CTLLGGLART HERKQQALNL LTSFLYHVGD AGEASNEYLA LYRSIATESP
     WLQYLVLRGV LCKISSLLAT EIAKVHCMEE HSLSSDLTLG YALRRYVELL WLFLECPNIR
     RTYKTRLLGP VLESYLALRS LVVQRTRHID EAQEKLLEML EEMTSGTEEE TRAFMEILID
     TVDKTRMNDI KTPVFIFERL YSIIHPEEHD ESEFYMTLEK DPQQEDFLQG RMLGNPYPSG
     EMGLGPLMRD VKNKICTDCE LIALLEDDNG MELLVNNKII SLDLPVKDVY KKVWLAEGGD
     RDAMRIVYRM RGLLGDATEE FVETLNNKSQ EAVDTEQLYR MANVLADCNG LRVMLDRIGS
     LQRISRQREL IQVLLKLFLI CVKVRRCQEV LCQPEIGAIN TLLKVLQMCL QSENDSIQSA
     VTEQLLEIME TLLSKAASDT LDSFLQFSLT FGGPEYVSAL ISCTDCPNVR NNPSVLRHLI
     RVLAALVYGN EVKMALLCEH FKDTLNFKRF DNERTPEEEF KLELFCVLTN QIEHNCIGGT
     LKDYIVSLGI VERSLAYITE HAPCVKPTLL RTDSDELKEF ISRPSLKYIL RFLTGLSNHH
     EATQVAISKD IIPIIHRLEQ VSSDEHVGSL AENLLEALST DAATAARVQQ VRDFTRAEKK
     RLAMATREKQ LDALGMRTNE KGQVTAKGSI LQKIEKLRDE TGLTCFICRE GYACQPEKVL
     GIYTFTKRCN VEEFELKSRK TIGYTTVTHF NVVHVDCHTS AIRLTRGRDE WERASLQNAN
     TRCNGLLPLW GPSVLETTFS ASMTRHSSYM QESTQRCDIS YTSSIHDLKL LLVRFAWERS
     FHDDAGGGGP QSNMHFVPYL LFYSIYMLLS SRSAARDSKT VLAYLTAPPS EKWLECGFEV
     EGPLYMITIS VTLHSRELWN KHKVAHLKRM LAVAQARHVS PSVLCKALLA PADRQVKDYS
     VYKPYLMMWA MIDMIYNILF KLVTMPKEEA WPVSLFDYIR KNDEAMLKST DGILHILTEE
     LLPCTSFGEF CDVAGLLTLI EQPDSFIEDL LASLPSTTSS S