POF11_SCHPO
ID POF11_SCHPO Reviewed; 506 AA.
AC Q09855; Q9P7V1;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 14-AUG-2001, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=F-box/WD repeat-containing protein pof11;
DE AltName: Full=Meiotically up-regulated gene 156 protein;
GN Name=pof11; Synonyms=mug156; ORFNames=SPAC29E6.01, SPAC30.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Harrison C.L., Toda T.;
RT "Systematic genome-wide analysis of F-box protein-encoding genes in fission
RT yeast.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP INTERACTION WITH SKP1.
RX PubMed=15147268; DOI=10.1111/j.1356-9597.2004.00730.x;
RA Lehmann A., Katayama S., Harrison C., Dhut S., Kitamura K., McDonald N.,
RA Toda T.;
RT "Molecular interactions of fission yeast Skp1 and its role in the DNA
RT damage checkpoint.";
RL Genes Cells 9:367-382(2004).
RN [4]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a role in meiosis. {ECO:0000269|PubMed:16303567}.
CC -!- SUBUNIT: Interacts with skp1. {ECO:0000269|PubMed:15147268}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
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DR EMBL; AB061694; BAB55543.1; -; Genomic_DNA.
DR EMBL; CU329670; CAB66464.1; -; Genomic_DNA.
DR EMBL; Z66525; CAA91423.1; -; Genomic_DNA.
DR PIR; T38502; S62507.
DR PIR; T50211; T50211.
DR RefSeq; NP_594559.1; NM_001019988.2.
DR AlphaFoldDB; Q09855; -.
DR SMR; Q09855; -.
DR BioGRID; 278202; 11.
DR IntAct; Q09855; 1.
DR STRING; 4896.SPAC29E6.01.1; -.
DR PaxDb; Q09855; -.
DR PRIDE; Q09855; -.
DR EnsemblFungi; SPAC29E6.01.1; SPAC29E6.01.1:pep; SPAC29E6.01.
DR GeneID; 2541707; -.
DR KEGG; spo:SPAC29E6.01; -.
DR PomBase; SPAC29E6.01; pof11.
DR VEuPathDB; FungiDB:SPAC29E6.01; -.
DR eggNOG; KOG0281; Eukaryota.
DR HOGENOM; CLU_000288_103_6_1; -.
DR InParanoid; Q09855; -.
DR OMA; ENNWRMG; -.
DR PhylomeDB; Q09855; -.
DR Reactome; R-SPO-174113; SCF-beta-TrCP mediated degradation of Emi1.
DR Reactome; R-SPO-8951664; Neddylation.
DR Reactome; R-SPO-9762114; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2.
DR Reactome; R-SPO-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR PRO; PR:Q09855; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; ISM:PomBase.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; ISM:PomBase.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ISM:PomBase.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Meiosis; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..506
FT /note="F-box/WD repeat-containing protein pof11"
FT /id="PRO_0000051138"
FT DOMAIN 70..116
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REPEAT 219..256
FT /note="WD 1"
FT REPEAT 259..298
FT /note="WD 2"
FT REPEAT 301..338
FT /note="WD 3"
FT REPEAT 345..386
FT /note="WD 4"
FT REPEAT 388..426
FT /note="WD 5"
FT REPEAT 427..464
FT /note="WD 6"
FT REPEAT 468..505
FT /note="WD 7"
SQ SEQUENCE 506 AA; 58257 MW; CEF34D4EFFBC2E10 CRC64;
MNQDDNGKNV VSKVSDLTSC SDFSTSSPVP CLNPLSHENN RIDLIRDLLA SLSKEGVVAV
YNHVRSLLFT DFTEVFPEEV SLRVFSYLDQ LDLCKCKLMS KRWKRLLEDP GIWKALYMQK
GWFVNENVLN EFEAWRRTHK FPQPRFENFL KQQNIIGPYG TMFLPQQFIF DSNGRPLLNW
SYLYKEHAHL DSNWRHGRFL VSTFNNPSIR FPADQDFRAT LDSVYCVQYD DEIMVSGSKD
RTVSVWDVNS RFILYKLYGH SGSVLCLDFC RRRNLLVSGS SDSTIIIWDW QNRRPLKVYF
GHTDNVLGVV VSENYIISSS RDHTARVWRL DATSPAEACM HVLRGHLASV NSVQYSSKTG
LIVTASSDRT LRTWDITTGH CIRIIHAHQR GIACAQYNGK FIVSGSSDLT IRIFEASSGK
LLRMLQGHED LIRTVRFNDE KIVSGGYDGT VRIWNFNTGE QHCVLHNSRN SRVFGLQFDH
RRIIACTHSS EILVWNFDDG LDCTFF
