ID   POF12_SCHPO             Reviewed;         440 AA.
AC   O60053;
DT   27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 121.
DE   RecName: Full=F-box protein pof12;
GN   Name=pof12; ORFNames=SPBC56F2.01;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Harrison C.L., Toda T.;
RT   "Systematic genome-wide analysis of F-box protein-encoding genes in fission
RT   yeast.";
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [3]
RP   INTERACTION WITH SKP1.
RX   PubMed=15147268; DOI=10.1111/j.1356-9597.2004.00730.x;
RA   Lehmann A., Katayama S., Harrison C., Dhut S., Kitamura K., McDonald N.,
RA   Toda T.;
RT   "Molecular interactions of fission yeast Skp1 and its role in the DNA
RT   damage checkpoint.";
RL   Genes Cells 9:367-382(2004).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- SUBUNIT: Interacts with skp1. {ECO:0000269|PubMed:15147268}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
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DR   EMBL; AB061726; BAB55637.1; -; Genomic_DNA.
DR   EMBL; CU329671; CAA18880.1; -; Genomic_DNA.
DR   PIR; T40543; T40543.
DR   RefSeq; NP_596716.1; NM_001022641.2.
DR   AlphaFoldDB; O60053; -.
DR   BioGRID; 277430; 19.
DR   IntAct; O60053; 1.
DR   STRING; 4896.SPBC56F2.01.1; -.
DR   PaxDb; O60053; -.
DR   EnsemblFungi; SPBC56F2.01.1; SPBC56F2.01.1:pep; SPBC56F2.01.
DR   GeneID; 2540914; -.
DR   KEGG; spo:SPBC56F2.01; -.
DR   PomBase; SPBC56F2.01; pof12.
DR   VEuPathDB; FungiDB:SPBC56F2.01; -.
DR   HOGENOM; CLU_615620_0_0_1; -.
DR   InParanoid; O60053; -.
DR   OMA; NIFSHET; -.
DR   PRO; PR:O60053; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0000151; C:ubiquitin ligase complex; ISM:PomBase.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; ISM:PomBase.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:PomBase.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   Pfam; PF12937; F-box-like; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..440
FT                   /note="F-box protein pof12"
FT                   /id="PRO_0000119977"
FT   DOMAIN          8..54
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
SQ   SEQUENCE   440 AA;  49997 MW;  471FBAC7F3921E81 CRC64;
     MTTDVKAKNP ASIFSHETLL HVLNDLSAHD LAALERVSRS WNSIVRRSSV WHNLYLSEFG
     TKHLRRHGRI EKKRRNWKGL FRRQSNWKDG RCKKVESMLP QLLNSEKSVG EDRLGLTLTH
     QNNIYFCNDV QISKWSSVGN SLKCQAISSF RDETVKSGPA VMCLDNASLY IGLKDGNLLH
     VTVHETGFGN IENLATFSTK FVALSSHKNY ICGLTNDNNL YILQHSHQAG TKLKVLGKYH
     VSSIEKQVAI HFQQSKEGYE VVHVVFNDYV LSGGWTVSLQ EFVFNEYCVK SSRLALHDNK
     DIEYSQQPAS AIFMYGSYIL TSHPDNSLIL QRLYSTNNEL RIKFLGRLLG HVCGVQISKL
     FSCGRIVSVS KNCADICVWD LHDTNYQSIV SPLMLTCTNI HNKPVSDYEK ECKVQDIGLY
     EDTILITLSD GRILKFLFNI