ID   POF1B_PONAB             Reviewed;         588 AA.
AC   Q5RBB5;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Protein POF1B;
GN   Name=POF1B;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a key role in the organization of epithelial monolayers
CC       by regulating the actin cytoskeleton. May be involved in ovary
CC       development (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with nonmuscle actin. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}.
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DR   EMBL; CR858736; CAH90945.1; -; mRNA.
DR   RefSeq; NP_001125542.1; NM_001132070.1.
DR   AlphaFoldDB; Q5RBB5; -.
DR   SMR; Q5RBB5; -.
DR   STRING; 9601.ENSPPYP00000022966; -.
DR   PRIDE; Q5RBB5; -.
DR   GeneID; 100172454; -.
DR   KEGG; pon:100172454; -.
DR   CTD; 79983; -.
DR   eggNOG; ENOG502QRUE; Eukaryota.
DR   InParanoid; Q5RBB5; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   InterPro; IPR026186; POF1B.
DR   PANTHER; PTHR22546; PTHR22546; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cell junction; Coiled coil; Reference proteome;
KW   Tight junction.
FT   CHAIN           1..588
FT                   /note="Protein POF1B"
FT                   /id="PRO_0000253913"
FT   COILED          332..442
FT                   /evidence="ECO:0000255"
FT   COILED          502..530
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   588 AA;  67950 MW;  555AC1BC9F7284E0 CRC64;
     MSSSYWSETS SSSCGTQLPE VLQCQPQHYH CYHQSSQAQQ PPEKNVVYER VRTYSGPMNK
     VVQALDPFNS REVLSPLKTT SSYQNLVWSD HSQELHSPTL KISTCAPSTL HITQNTEQEL
     HSPTVKVTTY PQTTIRKYVV QNPEQEPLSQ FLRGSQFFPG NNVIYEKTIR KVEKLNTDQG
     CHPQAQCHHH IVQQPQVIRS AHWQQPDSSQ QIQAITGNDP ISTHIGNELC HSGSSQIHEQ
     VIIQDDGPEK LDPRYFGELL ADLSRKNTDL YHCLLEHLQR IGGSKQDFES TDESEDIKSL
     IPKGLSEFTK QQIRYILQMR GMSDKSLRLV LSTFSNIREE LGHLQNDLTS LENDKMRLEK
     DLSFKETQLK EYEELLASVR ANNHQQQQGL QDSSSKCQAL EENNLSLRHT LSDMEYRLKE
     LEYCKRNLEQ ENQNLRMQVS ETCTGPMLQA KMDEIGNHYT EMVKNLRMEE DREICRLRSQ
     LNQYHKDVSK REGSCSDFQF KLHELTSLLE EKDSLIKRQS EELSKLRQEI YSSHNQPSTG
     GRTTITTKKY RTQYPILGLL YDDYEYIPPG SETQTIVIEK TEDKYTCP