POF4_SCHPO
ID POF4_SCHPO Reviewed; 263 AA.
AC O59671;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 3.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=Elongin-A;
DE AltName: Full=Protein pof4;
GN Name=pof4; Synonyms=ela1; ORFNames=SPBC29A3.08;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP IDENTIFICATION OF FRAMESHIFT.
RC STRAIN=972 / ATCC 24843, and JY3;
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP INTERACTION WITH SKP1.
RX PubMed=15147268; DOI=10.1111/j.1356-9597.2004.00730.x;
RA Lehmann A., Katayama S., Harrison C., Dhut S., Kitamura K., McDonald N.,
RA Toda T.;
RT "Molecular interactions of fission yeast Skp1 and its role in the DNA
RT damage checkpoint.";
RL Genes Cells 9:367-382(2004).
CC -!- SUBUNIT: Forms a complex with skp1-like protein elc1 (By similarity).
CC Interacts with skp1. {ECO:0000250, ECO:0000269|PubMed:15147268}.
CC -!- SIMILARITY: Belongs to the ELA1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA18385.2; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; CU329671; CAA18385.2; ALT_FRAME; Genomic_DNA.
DR PIR; T40079; T40079.
DR RefSeq; NP_595836.2; NM_001021740.2.
DR AlphaFoldDB; O59671; -.
DR IntAct; O59671; 1.
DR STRING; 4896.SPBC29A3.08.1; -.
DR iPTMnet; O59671; -.
DR PaxDb; O59671; -.
DR GeneID; 2540513; -.
DR KEGG; spo:SPBC29A3.08; -.
DR PomBase; SPBC29A3.08; pof4.
DR eggNOG; KOG2821; Eukaryota.
DR InParanoid; O59671; -.
DR Reactome; R-SPO-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-SPO-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR Reactome; R-SPO-75955; RNA Polymerase II Transcription Elongation.
DR PRO; PR:O59671; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0070449; C:elongin complex; ISO:PomBase.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IC:PomBase.
DR GO; GO:0003711; F:transcription elongation regulator activity; IC:PomBase.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IC:PomBase.
DR GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IC:PomBase.
DR InterPro; IPR010684; RNA_pol_II_trans_fac_SIII_A.
DR Pfam; PF06881; Elongin_A; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..263
FT /note="Elongin-A"
FT /id="PRO_0000058505"
FT REGION 112..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 263 AA; 29847 MW; 9726BA49F8F0EE0E CRC64;
MYSLKDLCIQ VAQKHVHDID DIGDCPFELV KPILEKARPE HLIDLEEKSP HLKVDTQPLW
KDHVLRDFGL ELQKRTILNN IDDWRGLYGK LKKKRNAHYN VASAKLRSAY TKLEQSKQNK
RIVPLEREPR AARPPKRPRP MSNYCPKSSL MARAKSDFLK KASATRHIVS ATSSSRSFPQ
LHPLGRSSSN ATNTSTKRPL TSNTYPSIPL PPKSFTSQNF KSFNAVKTQP SSSSSPSISR
PTSFPMSFFP NPSRFSSQVP KRI
