POG1_YEAST
ID POG1_YEAST Reviewed; 351 AA.
AC P40473; D6VVG5;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Transcriptional activator POG1;
DE AltName: Full=Promoter of growth protein 1;
GN Name=POG1; OrderedLocusNames=YIL122W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169870;
RA Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL Nature 387:84-87(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION.
RX PubMed=9927449; DOI=10.1093/genetics/151.2.531;
RA Leza M.A., Elion E.A.;
RT "POG1, a novel yeast gene, promotes recovery from pheromone arrest via the
RT G1 cyclin CLN2.";
RL Genetics 151:531-543(1999).
RN [4]
RP FUNCTION, AND INDUCTION.
RX PubMed=12464632; DOI=10.1101/gad.1039602;
RA Horak C.E., Luscombe N.M., Qian J., Bertone P., Piccirrillo S.,
RA Gerstein M., Snyder M.;
RT "Complex transcriptional circuitry at the G1/S transition in Saccharomyces
RT cerevisiae.";
RL Genes Dev. 16:3017-3033(2002).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [7]
RP PHOSPHORYLATION BY CDC28.
RX PubMed=14574415; DOI=10.1038/nature02062;
RA Ubersax J.A., Woodbury E.L., Quang P.N., Paraz M., Blethrow J.D., Shah K.,
RA Shokat K.M., Morgan D.O.;
RT "Targets of the cyclin-dependent kinase Cdk1.";
RL Nature 425:859-864(2003).
RN [8]
RP INDUCTION.
RX PubMed=16278933; DOI=10.1002/yea.1302;
RA de Lichtenberg U., Wernersson R., Jensen T.S., Nielsen H.B., Fausboell A.,
RA Schmidt P., Hansen F.B., Knudsen S., Brunak S.;
RT "New weakly expressed cell cycle-regulated genes in yeast.";
RL Yeast 22:1191-1201(2005).
RN [9]
RP FUNCTION.
RX PubMed=17986087; DOI=10.1111/j.1574-6968.2007.00947.x;
RA Demae M., Murata Y., Hisano M., Haitani Y., Shima J., Takagi H.;
RT "Overexpression of two transcriptional factors, Kin28 and Pog1, suppresses
RT the stress sensitivity caused by the rsp5 mutation in Saccharomyces
RT cerevisiae.";
RL FEMS Microbiol. Lett. 277:70-78(2007).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168 AND SER-314, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
CC -!- FUNCTION: Transcriptional activator which promotes cell cycle recovery
CC with CLN2, after pheromone induced G1 arrest, probably inhibiting the
CC ability of STE20 to activate the pheromone response pathway. Binds the
CC promoters of genes that function in cell cycle regulation, cytoskeletal
CC organization, and spindle assembly. May also be involved in stress-
CC resistance. {ECO:0000269|PubMed:12464632, ECO:0000269|PubMed:17986087,
CC ECO:0000269|PubMed:9927449}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14562095}.
CC -!- INDUCTION: Expressed periodically during cell division. Regulated by
CC the SBF complex which is one critical regulator of the start of the
CC cell cycle. {ECO:0000269|PubMed:12464632, ECO:0000269|PubMed:16278933}.
CC -!- PTM: Phosphorylated by CDC28. {ECO:0000305|PubMed:14574415}.
CC -!- MISCELLANEOUS: Present with 736 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the POG1 family. {ECO:0000305}.
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DR EMBL; Z46833; CAA86870.1; -; Genomic_DNA.
DR EMBL; BK006942; DAA08431.1; -; Genomic_DNA.
DR PIR; S49887; S49887.
DR RefSeq; NP_012144.1; NM_001179470.1.
DR AlphaFoldDB; P40473; -.
DR BioGRID; 34869; 114.
DR DIP; DIP-2755N; -.
DR IntAct; P40473; 8.
DR MINT; P40473; -.
DR STRING; 4932.YIL122W; -.
DR iPTMnet; P40473; -.
DR MaxQB; P40473; -.
DR PaxDb; P40473; -.
DR PRIDE; P40473; -.
DR EnsemblFungi; YIL122W_mRNA; YIL122W; YIL122W.
DR GeneID; 854684; -.
DR KEGG; sce:YIL122W; -.
DR SGD; S000001384; POG1.
DR VEuPathDB; FungiDB:YIL122W; -.
DR eggNOG; ENOG502S5H5; Eukaryota.
DR HOGENOM; CLU_792700_0_0_1; -.
DR InParanoid; P40473; -.
DR OMA; PQANIYG; -.
DR BioCyc; YEAST:G3O-31375-MON; -.
DR PRO; PR:P40473; -.
DR Proteomes; UP000002311; Chromosome IX.
DR RNAct; P40473; protein.
DR GO; GO:0000785; C:chromatin; IDA:SGD.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:SGD.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:SGD.
DR GO; GO:0000321; P:re-entry into mitotic cell cycle after pheromone arrest; IMP:SGD.
PE 1: Evidence at protein level;
KW Activator; Cell cycle; Cell division; Mitosis; Nucleus; Phosphoprotein;
KW Reference proteome; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..351
FT /note="Transcriptional activator POG1"
FT /id="PRO_0000202962"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 152
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18407956"
FT MOD_RES 168
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19779198"
FT MOD_RES 314
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19779198"
SQ SEQUENCE 351 AA; 39498 MW; 35EE3E9F93FDCE0C CRC64;
MKQEPHRQSE EKEKPKGPMA VEREQHTSLS SGTTVTASTG DESTNSRPVE SSQTEKSLSL
RIRILKQLGF DDIQELNACD TGLVEQFLNV RLINDTKELE KIRESNLAKL NQIIDKCMES
DKISDSTLNK ILDMSMNRDT NNDNNNHLTI PSPITTKKRK INASELASPR GHRRYRSDIP
TVSEVETGVG YPQIHQQPGA YTLPMPANQW MSNPYMQPPQ PQVQQIMPQY LYPPGMGPQA
QLPTMSSNSE SQTPVMSSQF LSLNQHGLYQ QNIGAHPVMS MGPQANIYGQ QHQLQPGQER
DQSRKSFSHR RSQSANISMA NFRSPMRNPQ PASSQRPVNF LIHTPKHPPP T
