ID   POK_METJA               Reviewed;         270 AA.
AC   Q58379;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Pantoate kinase {ECO:0000255|HAMAP-Rule:MF_02223};
DE            Short=PoK {ECO:0000255|HAMAP-Rule:MF_02223};
DE            EC=2.7.1.169 {ECO:0000255|HAMAP-Rule:MF_02223};
GN   OrderedLocusNames=MJ0969;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in
CC       the CoA biosynthesis pathway. {ECO:0000255|HAMAP-Rule:MF_02223}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-pantoate + ATP = (R)-4-phosphopantoate + ADP + H(+);
CC         Xref=Rhea:RHEA:28246, ChEBI:CHEBI:15378, ChEBI:CHEBI:15980,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61294, ChEBI:CHEBI:456216;
CC         EC=2.7.1.169; Evidence={ECO:0000255|HAMAP-Rule:MF_02223};
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_02223}.
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. PoK subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_02223}.
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DR   EMBL; L77117; AAB98974.1; -; Genomic_DNA.
DR   PIR; A64421; A64421.
DR   RefSeq; WP_010870483.1; NC_000909.1.
DR   AlphaFoldDB; Q58379; -.
DR   SMR; Q58379; -.
DR   STRING; 243232.MJ_0969; -.
DR   EnsemblBacteria; AAB98974; AAB98974; MJ_0969.
DR   GeneID; 1451867; -.
DR   KEGG; mja:MJ_0969; -.
DR   eggNOG; arCOG04263; Archaea.
DR   HOGENOM; CLU_081191_0_0_2; -.
DR   InParanoid; Q58379; -.
DR   OMA; MLGETVF; -.
DR   OrthoDB; 104702at2157; -.
DR   PhylomeDB; Q58379; -.
DR   UniPathway; UPA00241; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.230.10; -; 1.
DR   HAMAP; MF_02223; Pantoate_kinase; 1.
DR   InterPro; IPR006204; GHMP_kinase_N_dom.
DR   InterPro; IPR012043; PoK.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR42282; PTHR42282; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF016896; GHMP_arc_MJ0969; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coenzyme A biosynthesis; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..270
FT                   /note="Pantoate kinase"
FT                   /id="PRO_0000107123"
SQ   SEQUENCE   270 AA;  30035 MW;  F594A63020D4E66B CRC64;
     MFAPGHITGF FVICKSSNKL KTGSIGAGIT IDRGVNVELK EGNGSIFYNN KKVNICAVEK
     VIEHYKKFGY NDDYDIIFSS DFPLGSGLGM SGGCALILAK KLNEMLNLNE NYAEIAHISE
     VECGTGLGDV IAQYVKGFVI RKTPGFPINV EKIVVDDDYY IIIEIFGKKE TKEIITNDIW
     IKKINEYGER CLNELLKNPT LENFVNLSYE FAVNTGLINE KILSICEDLK FTVGASQSML
     GNTLFCISKK ETLEDALSIL KNPIVCNIYY