POL1_CHICK
ID POL1_CHICK Reviewed; 246 AA.
AC P10399;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Retrovirus-related Pol polyprotein;
DE Includes:
DE RecName: Full=Reverse transcriptase;
DE EC=2.7.7.49;
DE Includes:
DE RecName: Full=Endonuclease;
DE Flags: Fragments;
GN Name=POL;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2410912; DOI=10.1073/pnas.82.15.5097;
RA Dunwiddie C., Faras A.J.;
RT "Presence of retrovirus reverse transcriptase-related gene sequences in
RT avian cells lacking endogenous avian leukosis viruses.";
RL Proc. Natl. Acad. Sci. U.S.A. 82:5097-5101(1985).
RN [2]
RP SEQUENCE REVISION TO 2.
RA Dunwiddie C., Faras A.J.;
RL Submitted (OCT-1985) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49;
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DR EMBL; K03271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; K03272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; A38044; A25779.
DR AlphaFoldDB; P10399; -.
DR SMR; P10399; -.
DR VEuPathDB; HostDB:LOC100859106; -.
DR VEuPathDB; HostDB:LOC121109412; -.
DR InParanoid; P10399; -.
DR PhylomeDB; P10399; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0035613; F:RNA stem-loop binding; IBA:GO_Central.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR Gene3D; 1.10.10.200; -; 1.
DR Gene3D; 3.30.420.10; -; 1.
DR InterPro; IPR017856; Integrase-like_N.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR InterPro; IPR036397; RNaseH_sf.
DR Pfam; PF02022; Integrase_Zn; 1.
DR SUPFAM; SSF46919; SSF46919; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50876; ZF_INTEGRASE; 1.
PE 4: Predicted;
KW Endonuclease; Hydrolase; Metal-binding; Nuclease; Nucleotidyltransferase;
KW Reference proteome; RNA-directed DNA polymerase; Transferase; Zinc;
KW Zinc-finger.
FT CHAIN <1..>246
FT /note="Retrovirus-related Pol polyprotein"
FT /id="PRO_0000058507"
FT DOMAIN 202..>246
FT /note="Integrase catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00457"
FT ZN_FING 149..190
FT /note="Integrase-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00450"
FT BINDING 158
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00450"
FT BINDING 162
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00450"
FT BINDING 186
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00450"
FT BINDING 189
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00450"
FT NON_CONS 111..112
FT /evidence="ECO:0000305"
FT NON_TER 1
FT NON_TER 246
SQ SEQUENCE 246 AA; 26354 MW; EA036F7C0792C7C6 CRC64;
SAQPVRAFTP WVELLSLLLS KARTSAFRDF GKDLDIVHLP RFFRDSQILP DEILLALHGF
GGKLRYAGSL PIFELARPLR VSLRLRVVAS PLDGPTVFTD ASSSTGQGAV VLTARTAPAA
VLHVRSHSDV PGFFTTGNAL ADQHAGHKVL TVREADLHST LHLGARALSR TCSIPMAVAR
EVVQACPHCN SAPALSAGVN PRGIAPLDVW QTDFTLEPRL APRSWLAVTV DTASTVIVAT
QHGRAN
