ID   POL1_MOUSE              Reviewed;         120 AA.
AC   P10400;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Retrovirus-related Pol polyprotein;
DE   Includes:
DE     RecName: Full=Reverse transcriptase;
DE              EC=2.7.7.49;
DE   Includes:
DE     RecName: Full=Endonuclease;
DE   Flags: Fragment;
GN   Name=Pol;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (CLONE E1).
RX   PubMed=2415714; DOI=10.1128/jvi.56.3.691-700.1985;
RA   Levy D.E., Lerner R.A., Wilson M.C.;
RT   "Normal expression of polymorphic endogenous retroviral RNA containing
RT   segments identical to mink cell focus-forming virus.";
RL   J. Virol. 56:691-700(1985).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.49;
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DR   EMBL; M11301; AAA37560.1; -; mRNA.
DR   PIR; A29350; A29350.
DR   AlphaFoldDB; P10400; -.
DR   SMR; P10400; -.
DR   MaxQB; P10400; -.
DR   PeptideAtlas; P10400; -.
DR   PRIDE; P10400; -.
DR   ProteomicsDB; 289779; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P10400; protein.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR040643; MLVIN_C.
DR   Pfam; PF18697; MLVIN_C; 1.
PE   2: Evidence at transcript level;
KW   Endonuclease; Hydrolase; Nuclease; Nucleotidyltransferase;
KW   Reference proteome; RNA-directed DNA polymerase; Transferase.
FT   CHAIN           <1..120
FT                   /note="Retrovirus-related Pol polyprotein"
FT                   /id="PRO_0000058508"
FT   REGION          90..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..109
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   120 AA;  13302 MW;  0B4A2F30D1B83363 CRC64;
     PSLQAHLQAL QAVQREVWKP LAAAYQDQQD QPVIPHPFRV GDTVWVRRHQ TKNLEPRWKG
     PYTVLLTTPT ALKVDGIAAW IHAAHVKAAT TPPAGTASGP TWKVQRSQNP LKIRLTRGAP