ID   POL2_ARMVN              Reviewed;        1110 AA.
AC   Q91HK4;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=RNA2 polyprotein;
DE   AltName: Full=P2;
DE   Contains:
DE     RecName: Full=Protein 2A;
DE              Short=P2A;
DE   Contains:
DE     RecName: Full=Movement protein;
DE     AltName: Full=2B-MP;
DE   Contains:
DE     RecName: Full=Coat protein;
DE     AltName: Full=2C-CP;
OS   Arabis mosaic virus (isolate NW) (ArMV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Picornavirales; Secoviridae; Comovirinae; Nepovirus.
OX   NCBI_TaxID=282063;
OH   NCBI_TaxID=29760; Vitis vinifera (Grape).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=11325468; DOI=10.1016/s0168-1702(01)00235-0;
RA   Wetzel T., Meunier L., Jaeger U., Reustle G.M., Krczal G.;
RT   "Complete nucleotide sequences of the RNAs 2 of German isolates of
RT   Grapevine fanleaf and Arabis mosaic nepoviruses.";
RL   Virus Res. 75:139-145(2001).
CC   -!- FUNCTION: [Protein 2A]: Implicated in RNA2 replication. Could also be
CC       required for nematode transmission of the virus (By similarity).
CC       {ECO:0000250}.
CC   -!- FUNCTION: [Movement protein]: Transports viral genome to neighboring
CC       plant cells directly through plasmosdesmata, without any budding. The
CC       movement protein allows efficient cell to cell propagation, by
CC       bypassing the host cell wall barrier. Acts by forming a tubular
CC       structure at the host plasmodesmata, enlarging it enough to allow free
CC       passage of virion capsids (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: [Movement protein]: Host cell junction, host
CC       plasmodesma {ECO:0000250}. Note=Assembles in tubules that are embedded
CC       within modified plasmodesmata. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: [Coat protein]: Virion {ECO:0000305}.
CC   -!- PTM: Specific enzymatic cleavages in vivo by the P1 encoded 3C-like
CC       protease yield mature proteins. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Virions are comprised of 60 copies of the coat protein.
CC   -!- SIMILARITY: Belongs to the nepoviruses RNA2 polyprotein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY017339; AAK07728.1; -; Genomic_RNA.
DR   RefSeq; YP_053924.1; NC_006056.1.
DR   SMR; Q91HK4; -.
DR   PRIDE; Q91HK4; -.
DR   GeneID; 2943103; -.
DR   KEGG; vg:2943103; -.
DR   Proteomes; UP000007441; Genome.
DR   GO; GO:0044219; C:host cell plasmodesma; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.20; -; 2.
DR   InterPro; IPR005054; Nepo_coat.
DR   InterPro; IPR005305; Nepo_coat_C.
DR   InterPro; IPR005306; Nepo_coat_N.
DR   InterPro; IPR021081; Nepovirus_subgr_A_2A.
DR   InterPro; IPR029053; Viral_coat.
DR   Pfam; PF12312; NeA_P2; 1.
DR   Pfam; PF03391; Nepo_coat; 1.
DR   Pfam; PF03688; Nepo_coat_C; 1.
DR   Pfam; PF03689; Nepo_coat_N; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host cell junction; Transport; Viral movement protein;
KW   Virion.
FT   CHAIN           1..259
FT                   /note="Protein 2A"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000037094"
FT   CHAIN           260..605
FT                   /note="Movement protein"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000037095"
FT   CHAIN           606..1110
FT                   /note="Coat protein"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000037096"
FT   REGION          195..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..215
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1110 AA;  122186 MW;  BF0F7E6BF33B621D CRC64;
     MAKFYYSDRR LACWAAGKNP HLGGSIESWL AAIKSDSSFR QTVKEDVQVN RLQPTAVRMF
     SWKVGSGPID NPEKCNWHYV LTGEVPAQPT EPVKAREVVV PPVKVIPSPP PVPRPYFRPV
     GAFAPTRSGF IRATVERLSR KREESRAAAL FAELPLEYPQ GAPLVVPRGF AAMRWTYHAT
     WRRWYDASDE RALRVHPGGP ALPPPPPPPP IQKPPSFEER LQAALERQSC ARAFALETSL
     GLNMAWLGTA AIPSTSVCCA DGRTTGGQTI AQEADPINHR VTSNTAPGRA QWISERRSAL
     RRREQANSLQ SLAAQTDMTF EQARNAYLGA ADMVEQGLPL LPPLRNAYAP RGLWRGPSTR
     ANYTLDFRLN GIPTGQNTLE ILYNPVADEE MDEYRDRGMS AVVIDALEIA INPFGMPGNP
     TDLTVVATYG HERNMERAFI GSSSTFLGNG LARAIFFPGL QYSQEEPRRE SIIRLYVAST
     NATVDADSIL AAISVGTLRQ HIGSLHNRTV ASSVHAAQVQ GTTLRATMMG NAVVVSPEGS
     LVTGTPEANV QIGSGSSMRM VGPLAWENVE EPGQTFTIRN RSRSMRVDRN ADVGVALPRM
     STTTRGLAGR GSVQVPKDCQ AGRYLKTLDL RDMVSGFSGI QYEKWITAGL VMPDFKVVIR
     YPANAFTGIT WVMSFDAYNR ITSSITTTAS PAYTLSVPHW LLHHKNGTTS CDIDYGELCG
     HAMWFNATTF ESPKLHFTCL TGNNKELAAD WEFVVELYAE FEAAKTFLGR PNFVYSADAF
     NGSFKFLTIP PLEYDLSTTS AYKSVSLLLG QTLIDGTHKV YNYNNTLLSY YLGIGGVVKG
     RVHICSPCTY GIVLRVVSEW NGVTNNWNQL FKYPGCYIGE DGNFEIEIRS PYHRTPLRLL
     DAQAASAFTS TLNFYAISGP IAPSGETAKM PVVVQIDEIA LPDLSVPSFP NDYFLWVDFS
     AFTVDAEEYV IGSRFFDISS TTSTVHLGDN PFAHMIACHG LHHGILDLKL MWDLEGEFGK
     SSGGVTITKL CGDKATGMDG ASRVCALQNM GCETELYIGN FAGANPNSAL SLYSRWLAIK
     LDKARSMKML RILCKPRGNF EFYGRTCFRV