ID   POL2_CRLVP              Reviewed;         960 AA.
AC   Q6EWG8;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   23-FEB-2022, entry version 51.
DE   RecName: Full=RNA2 polyprotein;
DE   AltName: Full=P2;
DE   Contains:
DE     RecName: Full=Movement protein;
DE   Contains:
DE     RecName: Full=Capsid protein VP25;
DE   Contains:
DE     RecName: Full=Capsid protein VP20;
DE   Contains:
DE     RecName: Full=Capsid protein VP24;
OS   Cherry rasp leaf virus (isolate Potato/United States) (CRLV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Picornavirales; Secoviridae; Cheravirus.
OX   NCBI_TaxID=650137;
OH   NCBI_TaxID=230209; Balsamorhiza sagittata.
OH   NCBI_TaxID=3750; Malus domestica (Apple) (Pyrus malus).
OH   NCBI_TaxID=29818; Plantago major (Common plantain).
OH   NCBI_TaxID=42229; Prunus avium (Cherry) (Cerasus avium).
OH   NCBI_TaxID=3760; Prunus persica (Peach) (Amygdalus persica).
OH   NCBI_TaxID=50225; Taraxacum officinale (Common dandelion) (Leontodon taraxacum).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15503203; DOI=10.1007/s00705-004-0362-3;
RA   Thompson J.R., Perry K.L., De Jong W.;
RT   "A new potato virus in a new lineage of picorna-like viruses.";
RL   Arch. Virol. 149:2141-2154(2004).
CC   -!- FUNCTION: [Movement protein]: Transports viral genome to neighboring
CC       plant cells directly through plasmosdesmata, without any budding. The
CC       movement protein allows efficient cell to cell propagation, by
CC       bypassing the host cell wall barrier. Acts by forming a tubular
CC       structure at the host plasmodesmata, enlarging it enough to allow free
CC       passage of virion capsids (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: Capsid proteins VP20, VP24, and VP25 form a capsid enclosing
CC       the viral positive strand RNA genome. Together they form an icosahedral
CC       capsid pseudo T=3 with a diameter of approximately 30 nm (Potential).
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: [Movement protein]: Host cell junction, host
CC       plasmodesma {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: [Capsid protein VP25]: Virion {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: [Capsid protein VP20]: Virion {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: [Capsid protein VP24]: Virion {ECO:0000305}.
CC   -!- PTM: Specific enzymatic cleavages in vivo by the P1 encoded 3C-like
CC       protease yield mature proteins. {ECO:0000250}.
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DR   EMBL; AJ621358; CAF21714.1; -; Genomic_RNA.
DR   RefSeq; YP_081445.1; NC_006272.1.
DR   SMR; Q6EWG8; -.
DR   PRIDE; Q6EWG8; -.
DR   GeneID; 3021845; -.
DR   KEGG; vg:3021845; -.
DR   Proteomes; UP000006923; Genome.
DR   GO; GO:0044219; C:host cell plasmodesma; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.20; -; 1.
DR   InterPro; IPR029053; Viral_coat.
PE   3: Inferred from homology;
KW   Capsid protein; Host cell junction; Reference proteome; Transport;
KW   Viral movement protein; Virion.
FT   CHAIN           1..374
FT                   /note="Movement protein"
FT                   /id="PRO_5000072357"
FT   CHAIN           375..592
FT                   /note="Capsid protein VP25"
FT                   /id="PRO_5000072358"
FT   CHAIN           593..767
FT                   /note="Capsid protein VP20"
FT                   /id="PRO_5000072359"
FT   CHAIN           768..960
FT                   /note="Capsid protein VP24"
FT                   /id="PRO_5000072360"
FT   REGION          350..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            374..375
FT                   /note="Cleavage"
FT                   /evidence="ECO:0000255"
FT   SITE            592..593
FT                   /note="Cleavage"
FT                   /evidence="ECO:0000255"
FT   SITE            767..768
FT                   /note="Cleavage"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   960 AA;  106236 MW;  F4DB833C84272873 CRC64;
     MEPERSQLAP EEVPDSFRVE TPAAMLARLR AESAAKKEAA RRAAMPYNDD LLVGSELTYL
     AKDDVFGCGR SALKRLFSRP SAEENVVVSH PLSVKEQVVR YQRPRTDHDP YVAVYTPLPH
     ITEEQARKLM EKGFSNSSNV ALDMAVQSHV GQGTPLLAMC GIMDSRTDDP NEALQVAGYF
     DLGRDRCDLI SLPLINFPLN KEDFDDYMRG LYLCTMFHNV RGFQNNKALC SYSAVGFDQH
     KETPRCIRSR VKESWEDILA RNNENEFSRV QSGQNLLNAI EKERNEAIPD VGAHQFACVP
     PSKGTPQTSL LTSDGVIKRP NFTLPRSAST RFNMPLNMRY SGRNSVDTAR HSLTTNSGGR
     STSLRQDPNL LEGQGPSIDF TKIIFPTVVE RNFSNPRAEI VNTIKQLYGD TVETLSVNPP
     ESYSAERLIG RVFSTLHGSF GATDLVEGKV LMSVKIVDLL SSANLGALLL AEVLGGNLTM
     RVTALITLNK YTSFALKLVY DELAQLAPDA TNFGVASVLP GAIFPSQEKS FSFDFNIFSM
     GSYINFKENE GFGRISLVAL SSPNLPDQMP DSANITLEFS VVNVDTSVYN LGQGQCLDLD
     RFPVHVTSKS KALSGGAKHA QAEFSLNLYE LGPHFNRFQA ICGHLAGYSG DLIIDWMISA
     SALTNGRCYI VPVYDQNTFS EVSEEKLRQC KYVSKELSLN RSGTVHMPFS SSFGSYTKNK
     YPKLLFVFPG GISGPSGETI HVNIQVRDVL HFSGLGHQLL KPILAAEGPD PFSFHLFYLH
     CGTLKTESLN KGGMWCVPVS PINLAAMKHG TGSSLVFNES FVSKTHNWLH YMASCTAYWR
     GTLTYELRVT YNSRVNAVAN LVAFYTSQVE DLFGFSDKAV GDTGIASICG DAFSVRISIP
     FVTPTLWLRT YRNAYDVFTS CNGSLYFHLP TSGVKSVQLF VRAESDFSFE RFRALKAEYT