ID   POL2_RRVC               Reviewed;        1106 AA.
AC   Q6W8W3;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 69.
DE   RecName: Full=RNA2 polyprotein;
DE   AltName: Full=P2;
DE   Contains:
DE     RecName: Full=Protein 2A;
DE              Short=P2A;
DE   Contains:
DE     RecName: Full=Movement protein;
DE     AltName: Full=2B-MP;
DE   Contains:
DE     RecName: Full=Coat protein;
DE     AltName: Full=2C-CP;
OS   Raspberry ringspot virus (strain cherry) (RpRSV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Picornavirales; Secoviridae; Comovirinae; Nepovirus.
OX   NCBI_TaxID=281921;
OH   NCBI_TaxID=57918; Fragaria vesca (Woodland strawberry) (Potentilla vesca).
OH   NCBI_TaxID=39639; Narcissus pseudonarcissus (Daffodil).
OH   NCBI_TaxID=32247; Rubus idaeus (Raspberry).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=14602206; DOI=10.1016/j.virusres.2003.08.001;
RA   Ebel R., Schnabel A., Reustle G.M., Krczal G., Wetzel T.;
RT   "Complete nucleotide sequence of an isolate of the nepovirus raspberry
RT   ringspot virus from grapevine.";
RL   Virus Res. 97:141-144(2003).
CC   -!- FUNCTION: [Protein 2A]: Implicated in RNA2 replication. Could also be
CC       required for nematode transmission of the virus (By similarity).
CC       {ECO:0000250}.
CC   -!- FUNCTION: [Movement protein]: Transports viral genome to neighboring
CC       plant cells directly through plasmosdesmata, without any budding. The
CC       movement protein allows efficient cell to cell propagation, by
CC       bypassing the host cell wall barrier. Acts by forming a tubular
CC       structure at the host plasmodesmata, enlarging it enough to allow free
CC       passage of virion capsids (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: [Movement protein]: Host cell junction, host
CC       plasmodesma {ECO:0000250}. Note=Assembles in tubules that are embedded
CC       within modified plasmodesmata. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: [Coat protein]: Virion {ECO:0000305}.
CC   -!- PTM: Specific enzymatic cleavages in vivo by the P1 encoded 3C-like
CC       protease yield mature proteins. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Virions are comprised of 60 copies of the coat protein.
CC   -!- SIMILARITY: Belongs to the nepoviruses RNA2 polyprotein family.
CC       {ECO:0000305}.
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DR   EMBL; AY303788; AAQ73823.1; -; Genomic_RNA.
DR   RefSeq; NP_944488.1; NC_005267.1.
DR   SMR; Q6W8W3; -.
DR   PRIDE; Q6W8W3; -.
DR   GeneID; 2943114; -.
DR   KEGG; vg:2943114; -.
DR   Proteomes; UP000007182; Genome.
DR   GO; GO:0044219; C:host cell plasmodesma; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.20; -; 2.
DR   InterPro; IPR005054; Nepo_coat.
DR   InterPro; IPR005305; Nepo_coat_C.
DR   InterPro; IPR005306; Nepo_coat_N.
DR   InterPro; IPR029053; Viral_coat.
DR   Pfam; PF03391; Nepo_coat; 1.
DR   Pfam; PF03688; Nepo_coat_C; 1.
DR   Pfam; PF03689; Nepo_coat_N; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host cell junction; Transport; Viral movement protein;
KW   Virion.
FT   CHAIN           1..?
FT                   /note="Protein 2A"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000037106"
FT   CHAIN           ?..592
FT                   /note="Movement protein"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000037107"
FT   CHAIN           593..1106
FT                   /note="Coat protein"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000037108"
FT   REGION          224..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        225..241
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1106 AA;  123614 MW;  BA2C2EC03D7D214E CRC64;
     MSQFWGEFPE AVINTFQRLQ IALIGDIKKC PLSSPLFPEL SKLDAHSQHH LLASFELPRF
     GGVTPGVMEQ LHDAESELAE ARARLLRERL HAVANKENIP YLGDCMYYDA PGINQEELLQ
     AAFLEAPTPE WESGRIRPLW PKDDWFRDAK QGPYPEDYGD IPLGDFDNLY RAFDALVEEH
     WMSVYSTTLN PFALLRCGSE FVEECVVSAG SLIPACMMTD HHLQPTGDRQ ADKEERQDYA
     DSQDSIQSMG DFWKEFYSKD SGKKIPDSHK SRLANDPNKV GFTKSALFHK QPLAHSLAQT
     WANFRGTQDK ADLVKVTMDM NIEKYTVRLP DAVRTTAGPL YIEWINLPRM SENSARKLAE
     AGWNNADICG VDLAVKSHIA VGTPVRVIIS LVDGACSDMP TATMCAFEVN LAAQNNRSLN
     LPLLSLPFSR LLADLHDFQH RVKIACQFRD PEGFNVGTPM LSFSSLEFSE LKQTAFERNS
     LLRDSWSEIE KRACHGGGRC VASQGIVQTW EKEVNPPLKE YAPLVLPPVP QPKRNFIDQQ
     SGEVVRPLIQ KSRSMRFKSP SDLWSRPSVD GGSTFTLSPS RGSLRCDNVP GCAYEVDPLH
     LLYYELVNVP KDTLGGTLLT RIDVRAKAAT FDSAVWRQWV RDGCLKPKIK MRITAATSCF
     SGIVLGACLD AYRRIPATTK TDFTASLVTG LPNIVWATRD TSEIEWDIDL AAVCGHTFFA
     LEDTFGYMDF LVYVLRGNEV TAVADWSIYV SFHVDWTQES MSATLIPTFV WPPEPADISY
     FKEVWGPYHF TLDGTEAKES FSLMPGMAIP RGAQTVRTFP RVLAAHFRSW TGKVRMSIQE
     VSSIFLTGTY MVGVSWNATA DLTDITTRKH WIVKSGEVFE LDLYCPYGEN PTFTGLVNGI
     PYIIVHRLGG IIGPKDSVGT FGFMIHLHGL TGVYKNPTLH SGDRSVGSAW FRVTNILDDN
     LVFNIPGRIE DMVAVAGKYE VTNYANPTSM LFSVTGLHGG FIRLHITWCP NTSLGESKGT
     LKYMQYLYHT TTENFFGDQA TRGIIDQNGF TVDLACGDFF GATRVGLKGE VERLGIYSSN
     AKSIAEIRVS FEILSMKFYG STIRVK