ID   POL2_TRSV               Reviewed;        1101 AA.
AC   Q6UR06;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 70.
DE   RecName: Full=RNA2 polyprotein;
DE   AltName: Full=P2;
DE   Contains:
DE     RecName: Full=Protein 2A;
DE              Short=P2A;
DE   Contains:
DE     RecName: Full=Movement protein;
DE     AltName: Full=2B-MP;
DE   Contains:
DE     RecName: Full=Coat protein;
DE     AltName: Full=2C-CP;
OS   Tobacco ringspot virus (TobRV) (TRSV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Picornavirales; Secoviridae; Comovirinae; Nepovirus.
OX   NCBI_TaxID=12282;
OH   NCBI_TaxID=22868; Anemone.
OH   NCBI_TaxID=90645; Bacopa.
OH   NCBI_TaxID=4072; Capsicum annuum (Capsicum pepper).
OH   NCBI_TaxID=3649; Carica papaya (Papaya).
OH   NCBI_TaxID=3654; Citrullus lanatus (Watermelon) (Citrullus vulgaris).
OH   NCBI_TaxID=4281; Cornus.
OH   NCBI_TaxID=3656; Cucumis melo (Muskmelon).
OH   NCBI_TaxID=3659; Cucumis sativus (Cucumber).
OH   NCBI_TaxID=66679; Daphne.
OH   NCBI_TaxID=38871; Fraxinus (ash trees).
OH   NCBI_TaxID=49747; Gladiolus.
OH   NCBI_TaxID=3847; Glycine max (Soybean) (Glycine hispida).
OH   NCBI_TaxID=16107; Hemerocallis.
OH   NCBI_TaxID=23109; Hydrangea.
OH   NCBI_TaxID=127142; Impatiens walleriana.
OH   NCBI_TaxID=26378; Iris.
OH   NCBI_TaxID=4382; Lobelia.
OH   NCBI_TaxID=3869; Lupinus.
OH   NCBI_TaxID=3750; Malus domestica (Apple) (Pyrus malus).
OH   NCBI_TaxID=283210; Malus pumila (Paradise apple).
OH   NCBI_TaxID=21819; Mentha.
OH   NCBI_TaxID=39639; Narcissus pseudonarcissus (Daffodil).
OH   NCBI_TaxID=4097; Nicotiana tabacum (Common tobacco).
OH   NCBI_TaxID=4030; Pelargonium.
OH   NCBI_TaxID=4101; Petunia.
OH   NCBI_TaxID=3885; Phaseolus vulgaris (Kidney bean) (French bean).
OH   NCBI_TaxID=103544; Phlox subulata.
OH   NCBI_TaxID=3582; Portulaca.
OH   NCBI_TaxID=42229; Prunus avium (Cherry) (Cerasus avium).
OH   NCBI_TaxID=137206; Prunus incisa.
OH   NCBI_TaxID=3760; Prunus persica (Peach) (Amygdalus persica).
OH   NCBI_TaxID=1358727; Prunus serrula.
OH   NCBI_TaxID=97321; Prunus serrulata.
OH   NCBI_TaxID=132459; Pueraria montana.
OH   NCBI_TaxID=23216; Rubus (bramble).
OH   NCBI_TaxID=211815; Rubus plicatus.
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OH   NCBI_TaxID=4111; Solanum melongena (Eggplant) (Aubergine).
OH   NCBI_TaxID=69266; Vaccinium corymbosum (Highbush blueberry).
OH   NCBI_TaxID=3917; Vigna unguiculata (Cowpea).
OH   NCBI_TaxID=29760; Vitis vinifera (Grape).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Moon J.S., Domier L.L., Hartman G.L.;
RT   "Nucleotide sequence of Tobacco ringspot virus RNA2.";
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: [Protein 2A]: Implicated in RNA2 replication. Could also be
CC       required for nematode transmission of the virus (By similarity).
CC       {ECO:0000250}.
CC   -!- FUNCTION: [Movement protein]: Transports viral genome to neighboring
CC       plant cells directly through plasmosdesmata, without any budding. The
CC       movement protein allows efficient cell to cell propagation, by
CC       bypassing the host cell wall barrier. Acts by forming a tubular
CC       structure at the host plasmodesmata, enlarging it enough to allow free
CC       passage of virion capsids (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: [Movement protein]: Host cell junction, host
CC       plasmodesma {ECO:0000250}. Note=Assembles in tubules that are embedded
CC       within modified plasmodesmata. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: [Coat protein]: Virion {ECO:0000305}.
CC   -!- PTM: Specific enzymatic cleavages in vivo by the P1 encoded 3C-like
CC       protease yield mature proteins. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Virions are comprised of 60 copies of the coat protein.
CC   -!- SIMILARITY: Belongs to the nepoviruses RNA2 polyprotein family.
CC       {ECO:0000305}.
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DR   EMBL; AY363727; AAQ63694.1; -; Genomic_RNA.
DR   RefSeq; NP_919039.1; NC_005096.1.
DR   SMR; Q6UR06; -.
DR   GeneID; 2943106; -.
DR   KEGG; vg:2943106; -.
DR   Proteomes; UP000201113; Genome.
DR   GO; GO:0044219; C:host cell plasmodesma; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0046740; P:transport of virus in host, cell to cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.20; -; 2.
DR   InterPro; IPR005054; Nepo_coat.
DR   InterPro; IPR005305; Nepo_coat_C.
DR   InterPro; IPR005306; Nepo_coat_N.
DR   InterPro; IPR029053; Viral_coat.
DR   Pfam; PF03391; Nepo_coat; 1.
DR   Pfam; PF03688; Nepo_coat_C; 1.
DR   Pfam; PF03689; Nepo_coat_N; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host cell junction; Transport; Viral movement protein;
KW   Virion.
FT   CHAIN           1..228
FT                   /note="Protein 2A"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000037112"
FT   CHAIN           229..588
FT                   /note="Movement protein"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000037113"
FT   CHAIN           589..1101
FT                   /note="Coat protein"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000037114"
SQ   SEQUENCE   1101 AA;  122235 MW;  792DE76C871CDF9E CRC64;
     MEPLLWHVDA TTPSHIQALQ SGSLPPASPA AALTRVQRAL SFFRTAARKY CKQADAPDLF
     ALAMTRVAEH NDIAVDARNV EQLFHFVGQH VANTAERKAL RAALREQRAL FKASLPGACF
     PAPAPPGWGI PKPPPLPPPF VWKGCRYNVV APPPRIPQPP PLPKFAPFVR NNFRVVAPPP
     LGEVYQPVGA PFPQTRASAA LSFFRTASTC RQVLVESCIQ QPAFMTCCAS TGEVQEMTSM
     LTEARQTGKI LTPKEVSQAL AQKRKEIKGA EENRISFDEG VHLTEADVFH RLSLAKRFMA
     HKRDRTLVDV LMPTEHEVVR YPGTRPDGTL QMCVSALPRM SEEAARKLLE KGWKNSKNVS
     LDIGVTSYMP YGAPIVAFMT IMDGRTDDPQ EAALCANYMD LGREKSKVLS LPLVTIPLSE
     IEHDQGILDC LYIVTYFHGV QSYQPGTLMM SYGTLEFQEY SNNSFTTATR VRESWDQILK
     RNENLGKRVH AGIGVLGTIE KEMDQQLEDF PAINLETRPR PVVRTFQNAH QPLHKTRSMR
     IGTTSFTGNT GRTVLPPVVK TYEEGNANFD SLQSKPRHSS ASTAHLMCAV TVVPDPTCCG
     TLSFKVPKDA KKGKHLGTFD IRQAIMEYGG LHSQEWCAKG IVNPTFTVRM HAPRNAFAGL
     SIACTFDDYK RIDLPALGNE CPPSEMFELP TKVFMLKDAD VHEWQFNYGE LTGHGLCNWA
     NVVTQPTLYF FVASTNQVTM AADWQCIVTM HVDMGPVIDR FELVPTMTWP IQLGDTFAID
     RYYEAKEIKL DGSTSMLSIS YNFGGPVKHS KKHAISYSRA VMSRNLGWSG TISGSVKSVS
     SLFCTASFVI FPWEHEAPPT LRQVLWGPHQ IMHGDGQFEI AIKTRLHSAA TTEEGFGRLG
     ILPLSGPIAP DAHVGSYEFI VHIDTWRPDS QVHPPMFSSA ELYNWFTLTN LKPDANTGVV
     NFDIPGYIHD FASKDATVTL ASNPLSWLVA ATGWHYGEVD LCISWPRSKQ AQAQEGSVSI
     TTNYRDWGAY WQGQARIYDL RRTEAEIPIF LGSYAGATPS GALGKQNYVR ISIVNAKDIV
     ALRVCLRPKS IKFWGRSATL F