POLC7_CYNDA
ID POLC7_CYNDA Reviewed; 80 AA.
AC P94092; Q9SAR4;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2001, sequence version 2.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Polcalcin Cyn d 7;
DE AltName: Full=Calcium-binding pollen allergen Cyn d 7;
DE AltName: Full=Calcium-binding protein B1;
DE AltName: Allergen=Cyn d 7;
OS Cynodon dactylon (Bermuda grass) (Panicum dactylon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Chloridoideae; Cynodonteae; Eleusininae; Cynodon.
OX NCBI_TaxID=28909;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Pollen;
RX PubMed=9037188; DOI=10.1016/s0014-5793(96)01520-7;
RA Suphioglu C., Ferreira F., Knox R.B.;
RT "Molecular cloning and immunological characterisation of Cyn d 7, a novel
RT calcium-binding allergen from Bermuda grass pollen.";
RL FEBS Lett. 402:167-172(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pollen;
RX PubMed=9363908; DOI=10.1159/000237678;
RA Smith P.M., Xu H., Swoboda I., Singh M.B.;
RT "Identification of a Ca2+ binding protein as a new Bermuda grass pollen
RT allergen Cyn d 7: IgE cross-reactivity with oilseed rape pollen allergen
RT Bra r 1.";
RL Int. Arch. Allergy Immunol. 114:265-271(1997).
CC -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC49648.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAA62634.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X91256; CAA62634.1; ALT_INIT; mRNA.
DR EMBL; U35683; AAC49648.1; ALT_INIT; Genomic_DNA.
DR EMBL; U75585; AAD00247.1; -; mRNA.
DR AlphaFoldDB; P94092; -.
DR SMR; P94092; -.
DR Allergome; 280; Cyn d 7.
DR Allergome; 3238; Cyn d 7.0101.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 1: Evidence at protein level;
KW Allergen; Calcium; Metal-binding; Repeat.
FT CHAIN 1..80
FT /note="Polcalcin Cyn d 7"
FT /id="PRO_0000073672"
FT DOMAIN 2..37
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 40..72
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 15
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 17
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 19
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 21
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 26
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 50
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 52
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 54
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 61
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 80 AA; 8801 MW; F83347BD7C2676F5 CRC64;
MADTGDMEHI FKRFDTNGDG KISLAELTDA LRTLGSTSAD EVQRMMAEID TDGDGFIDFD
EFISFCNANP GLMKDVAKVF
