ID   POLG_CYVV               Reviewed;         391 AA.
AC   P20177; Q66344;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Genome polyprotein;
DE   Contains:
DE     RecName: Full=Nuclear inclusion protein B;
DE              Short=NI-B;
DE              Short=NIB;
DE     AltName: Full=RNA-directed RNA polymerase;
DE              EC=2.7.7.48;
DE   Contains:
DE     RecName: Full=Capsid protein;
DE              Short=CP;
DE     AltName: Full=Coat protein;
DE   Flags: Fragment;
OS   Clover yellow vein virus.
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Stelpaviricetes;
OC   Patatavirales; Potyviridae; Potyvirus.
OX   NCBI_TaxID=12198;
OH   NCBI_TaxID=4047; Coriandrum sativum (Coriander) (Chinese parsley).
OH   NCBI_TaxID=4039; Daucus carota (Wild carrot).
OH   NCBI_TaxID=3847; Glycine max (Soybean) (Glycine hispida).
OH   NCBI_TaxID=70371; Limonium sinuatum.
OH   NCBI_TaxID=3873; Lupinus luteus (European yellow lupine).
OH   NCBI_TaxID=3888; Pisum sativum (Garden pea).
OH   NCBI_TaxID=74517; Trifolium hybridum (Alsike clover).
OH   NCBI_TaxID=60916; Trifolium incarnatum (Crimson clover).
OH   NCBI_TaxID=57577; Trifolium pratense (Red clover).
OH   NCBI_TaxID=3899; Trifolium repens (Creeping white clover).
OH   NCBI_TaxID=3900; Trifolium subterraneum (Subterranean clover).
OH   NCBI_TaxID=97047; Trifolium vesiculosum.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate No. 30;
RX   PubMed=1864719; DOI=10.1159/000150205;
RA   Uyeda I., Takahashi T., Shikata E.;
RT   "Relatedness of the nucleotide sequence of the 3'-terminal region of clover
RT   yellow vein potyvirus RNA to bean yellow mosaic potyvirus RNA.";
RL   Intervirology 32:234-245(1991).
RN   [2]
RP   SEQUENCE REVISION.
RA   Takahashi Y., Uyeda I.;
RL   Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   REVIEW.
RX   PubMed=11226583; DOI=10.1016/s0168-1702(01)00220-9;
RA   Urcuqui-Inchima S., Haenni A.L., Bernardi F.;
RT   "Potyvirus proteins: a wealth of functions.";
RL   Virus Res. 74:157-175(2001).
CC   -!- FUNCTION: [Nuclear inclusion protein B]: An RNA-dependent RNA
CC       polymerase that plays an essential role in the virus replication.
CC   -!- FUNCTION: [Capsid protein]: Involved in aphid transmission, cell-to-
CC       cell and systemis movement, encapsidation of the viral RNA and in the
CC       regulation of viral RNA amplification. {ECO:0000250|UniProtKB:P04517}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU00539};
CC   -!- SUBCELLULAR LOCATION: [Capsid protein]: Virion {ECO:0000305}.
CC   -!- PTM: Genome polyprotein of potyviruses undergoes post-translational
CC       proteolytic processing by the main proteinase NIa-pro resulting in the
CC       production of at least ten individual proteins. The P1 proteinase and
CC       the HC-pro cleave only their respective C-termini autocatalytically.
CC       6K1 is essential for proper proteolytic separation of P3 from CI (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the potyviridae genome polyprotein family.
CC       {ECO:0000305}.
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DR   EMBL; D86044; BAA12975.1; -; Genomic_RNA.
DR   PIR; JQ1056; JQ0461.
DR   SMR; P20177; -.
DR   GO; GO:0030430; C:host cell cytoplasm; ISS:UniProtKB.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001592; Poty_coat.
DR   Pfam; PF00767; Poty_coat; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Nucleotidyltransferase; RNA-directed RNA polymerase;
KW   Transferase; Viral RNA replication; Virion.
FT   CHAIN           <1..120
FT                   /note="Nuclear inclusion protein B"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000040266"
FT   CHAIN           1..391
FT                   /note="Genome polyprotein"
FT                   /id="PRO_0000419997"
FT   CHAIN           121..391
FT                   /note="Capsid protein"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000040267"
FT   REGION          127..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..152
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            120..121
FT                   /note="Cleavage; by NIa-pro"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   391 AA;  44876 MW;  834A320DB6CFE443 CRC64;
     IKKEGLWIPK LEPERVVSIL EWDRAAEPEH RLEAICASMI EAWGYDDLLN HIRRFYLWVL
     DQAPYKQLSA EGKAPYISEV ALKSLYTGKP ATSCELEVYN KIHQEQHDEF DDSQMKFVFQ
     SDKEKLNVGE QQKSKDKESR QRDQEGENSN RQIIPDRDIN AGTTGTFSVP KLKKISGKLS
     LPKIKGKGLL NLDHLLVYVP NQDDISNNIA TQEQLEAWHE GVKNAYEVDD QQMEIICNGL
     MVWCIENGTS GDLQGEWTMM DGEKQVTFPL KPILDFAKPT LRQIMAHFSQ AAESYIEFRN
     STEKYMPRYG LQRNLTDYGL ARYAFDFYRL TSKTPARARE AHMQMKAAAI RGKSNHMFGL
     DGNVGTDEEN TERHTANDVN RNMHHIAGAR F