AT331_ASPTN
ID AT331_ASPTN Reviewed; 551 AA.
AC Q0D153;
DT 15-FEB-2017, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=MFS-type transporter ATEG_00331 {ECO:0000305};
DE AltName: Full=Isoflavipucine biosynthesis cluster protein ATEG_00331 {ECO:0000303|PubMed:21236704};
DE Flags: Precursor;
GN ORFNames=ATEG_00331;
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156;
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION IN THE ISOFLAVIPUCINE CLUSTER, FUNCTION, AND INDUCTION.
RX PubMed=21236704; DOI=10.1016/j.chembiol.2010.12.011;
RA Gressler M., Zaehle C., Scherlach K., Hertweck C., Brock M.;
RT "Multifactorial induction of an orphan PKS-NRPS gene cluster in Aspergillus
RT terreus.";
RL Chem. Biol. 18:198-209(2011).
CC -!- FUNCTION: MFS-type transporter; part of the gene cluster that mediates
CC the biosynthesis of isoflavipucine (PubMed:21236704).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Expression is positively controled by the cluster-specific
CC regulator ATEG_00326 (PubMed:21236704). {ECO:0000269|PubMed:21236704}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC family. {ECO:0000305}.
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DR EMBL; CH476594; EAU38977.1; -; Genomic_DNA.
DR RefSeq; XP_001210417.1; XM_001210417.1.
DR AlphaFoldDB; Q0D153; -.
DR SMR; Q0D153; -.
DR STRING; 341663.Q0D153; -.
DR EnsemblFungi; EAU38977; EAU38977; ATEG_00331.
DR GeneID; 4355083; -.
DR VEuPathDB; FungiDB:ATEG_00331; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_000960_22_0_1; -.
DR OMA; LHADSSW; -.
DR OrthoDB; 653366at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 2.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..551
FT /note="MFS-type transporter ATEG_00331"
FT /id="PRO_5004170728"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 493..513
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 165
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 524
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 551 AA; 58992 MW; 7A85D997519E3743 CRC64;
MKAWLLVSSL CLSTFIAALE QTIISTAAES ISRSLHTTEL EFTWIGTAYL LPAAASTPPW
GKLSDIFGRK PVLMISIVVF FIGSLIGALA INIDMLIAGR VIQGTGGGGI LGLSATVIGD
VFSPRERSKY YGVLGVTWGV ACGLGPIVGG AFCQYVSWRW CFWINRTSLP QSSPNPLNLT
TSVPVAGVAG ALVLLFLEVH TPRTPIIEGL LAMDWLGTIT IVGATVMFLL GLGYGGIAYP
WNSATVVCLI VFGIGDNRRL RPDRMEGRQV LDHAAAPVQI PPPISPPSAS AYIHGLRLHR
PTLYYPPAVL SRSCSAPPRS LSGVYLLPVA VTLCVASTAT GLYISHSGRY RPPIYFGLVM
MILGHGLYIN LQPYASWARI IIFQIIAGLG LGPLFQAPII AIFSLTKPAD TASAAATVFF
ARDIATAMSI VFGGVIFQNR IRAFKSDIEG VVSPELTELI TSGGATTASD QIRALPAAAR
SLVRDRYNTA LRSEWIFYTA LSGAALLLSV FISKQVLSRD HKMNKTGLDV QEASRLEELE
KEKKAAATDA V
