ID   AT391_HYAAE             Reviewed;         185 AA.
AC   H9BPR8;
DT   05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2012, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Avirulence protein ATR39-1 {ECO:0000303|PubMed:22359513};
DE   AltName: Full=Arabidopsis thaliana recognized protein 39-1 {ECO:0000303|PubMed:22359513};
DE   Flags: Precursor;
GN   Name=ATR39-1 {ECO:0000303|PubMed:22359513};
OS   Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS   (Peronospora arabidopsidis).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Hyaloperonospora.
OX   NCBI_TaxID=559515;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=Emoy2;
RX   PubMed=22359513; DOI=10.1371/journal.pgen.1002502;
RA   Goritschnig S., Krasileva K.V., Dahlbeck D., Staskawicz B.J.;
RT   "Computational prediction and molecular characterization of an oomycete
RT   effector and the cognate Arabidopsis resistance gene.";
RL   PLoS Genet. 8:E1002502-E1002502(2012).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Emoy2;
RX   PubMed=21148394; DOI=10.1126/science.1195203;
RA   Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA   Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA   Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K., Dong S.,
RA   Downton P., Dumas B., Fabro G., Fronick C., Fuerstenberg S.I., Fulton L.,
RA   Gaulin E., Govers F., Hughes L., Humphray S., Jiang R.H., Judelson H.,
RA   Kamoun S., Kyung K., Meijer H., Minx P., Morris P., Nelson J.,
RA   Phuntumart V., Qutob D., Rehmany A., Rougon-Cardoso A., Ryden P.,
RA   Torto-Alalibo T., Studholme D., Wang Y., Win J., Wood J., Clifton S.W.,
RA   Rogers J., Van den Ackerveken G., Jones J.D., McDowell J.M., Beynon J.,
RA   Tyler B.M.;
RT   "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora
RT   arabidopsidis genome.";
RL   Science 330:1549-1551(2010).
CC   -!- FUNCTION: Secreted effector that acts as an elicitor of hypersensitive
CC       response (HR) specifically on plants carrying defense protein RPP39
CC       (PubMed:22359513). The allele ATR39-1 is recognized by RPP39, whereas
CC       the ATR39-2 allele is not recognized (PubMed:22359513).
CC       {ECO:0000269|PubMed:22359513}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:22359513}. Host cell
CC       {ECO:0000305|PubMed:22359513}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:22359513}.
CC   -!- MISCELLANEOUS: ATR39 has 2 polymorphic alleles that are highly
CC       conserved among Hyaloperonospora arabidopsidis isolate. This
CC       conservation is in stark contrast with other characterized
CC       H.arabidopsidis effectors ATR1, ATR5 and ATR13, which are highly
CC       divergent. The presence of amino acids 'Glu-168' and 'Val-169' in
CC       ATR39-2 blocks recognition by host defense protein RPP39.
CC       {ECO:0000269|PubMed:22359513}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; JQ045572; AFD62207.1; -; Genomic_DNA.
DR   EMBL; JH597954; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H9BPR8; -.
DR   PHI-base; PHI:4771; -.
DR   Proteomes; UP000011713; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0043657; C:host cell; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Reference proteome; Secreted; Signal; Virulence.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..185
FT                   /note="Avirulence protein ATR39-1"
FT                   /id="PRO_5003618370"
FT   MOTIF           49..66
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:22359513"
SQ   SEQUENCE   185 AA;  20242 MW;  465BF425E53F51AD CRC64;
     MVKCTPLLAL TVIVSAGSDA LSDPTVKRLA KLATINQAPA TQSNSDSKRV LRASDVPDEV
     AAGESRSPKS LWPWEVEDKL APLKEKLIST SADDLEAGGS ANKNALPMIW RWLWQNQIET
     KKTPIDEISK EVQTAMDLIS SQATHEELNK AGVSVSDYVK ALRFTLSDID VVNRGMEYNI
     HLGNK