ID   POLG_SUMVS              Reviewed;         365 AA.
AC   P25242;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Genome polyprotein;
DE   Contains:
DE     RecName: Full=Nuclear inclusion protein B;
DE              Short=NI-B;
DE              Short=NIB;
DE     AltName: Full=RNA-directed RNA polymerase;
DE              EC=2.7.7.48;
DE   Contains:
DE     RecName: Full=Capsid protein;
DE              Short=CP;
DE     AltName: Full=Coat protein;
DE   Flags: Fragment;
OS   Sugarcane mosaic virus (strain SC).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Stelpaviricetes;
OC   Patatavirales; Potyviridae; Potyvirus.
OX   NCBI_TaxID=12225;
OH   NCBI_TaxID=4510; Eleusine.
OH   NCBI_TaxID=4539; Panicum.
OH   NCBI_TaxID=4546; Saccharum.
OH   NCBI_TaxID=4554; Setaria.
OH   NCBI_TaxID=4558; Sorghum bicolor (Sorghum) (Sorghum vulgare).
OH   NCBI_TaxID=4577; Zea mays (Maize).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1993866; DOI=10.1099/0022-1317-72-2-237;
RA   Frenkel M.J., Jilka J.M., McKern N.M., Strike P.M., Clark J.M. Jr.,
RA   Shukla D.D., Ward C.W.;
RT   "Unexpected sequence diversity in the amino-terminal ends of the coat
RT   proteins of strains of sugarcane mosaic virus.";
RL   J. Gen. Virol. 72:237-242(1991).
RN   [2]
RP   REVIEW.
RX   PubMed=11226583; DOI=10.1016/s0168-1702(01)00220-9;
RA   Urcuqui-Inchima S., Haenni A.L., Bernardi F.;
RT   "Potyvirus proteins: a wealth of functions.";
RL   Virus Res. 74:157-175(2001).
CC   -!- FUNCTION: [Nuclear inclusion protein B]: An RNA-dependent RNA
CC       polymerase that plays an essential role in the virus replication.
CC   -!- FUNCTION: [Capsid protein]: Involved in aphid transmission, cell-to-
CC       cell and systemis movement, encapsidation of the viral RNA and in the
CC       regulation of viral RNA amplification. {ECO:0000250|UniProtKB:P04517}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU00539};
CC   -!- SUBCELLULAR LOCATION: [Capsid protein]: Virion {ECO:0000305}.
CC   -!- PTM: [Genome polyprotein]: Genome polyprotein of potyviruses undergoes
CC       post-translational proteolytic processing by the main proteinase NIa-
CC       pro resulting in the production of at least ten individual proteins.
CC       The P1 proteinase and the HC-pro cleave only their respective C-termini
CC       autocatalytically. 6K1 is essential for proper proteolytic separation
CC       of P3 from CI (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the potyviridae genome polyprotein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D00948; BAA00796.1; -; mRNA.
DR   PIR; PH0207; GNVSSC.
DR   SMR; P25242; -.
DR   GO; GO:0030430; C:host cell cytoplasm; ISS:UniProtKB.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR001592; Poty_coat.
DR   Pfam; PF00767; Poty_coat; 1.
PE   2: Evidence at transcript level;
KW   Capsid protein; Nucleotidyltransferase; RNA-directed RNA polymerase;
KW   Transferase; Virion.
FT   CHAIN           <1..52
FT                   /note="Nuclear inclusion protein B"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000040448"
FT   CHAIN           1..365
FT                   /note="Genome polyprotein"
FT                   /id="PRO_0000420025"
FT   CHAIN           53..365
FT                   /note="Capsid protein"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000040449"
FT   REGION          56..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          334..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            52..53
FT                   /note="Cleavage; by NIa-pro"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   365 AA;  39701 MW;  4FF2A9A1EB6E6DFA CRC64;
     KEGLAPYIAE TALRNLYLGS GIKEEEIEKY FKQFAKDLPG YLEDYNDEVF HQAGTVDAGA
     QGGGGNAGTQ PPATGAAAQG GAQPPATGAA AQPPTTQGSQ LPQGGATGGG GAQTGAGGTG
     SVTGGQRDKD VDAGTTGKIT VPKLKAMSKK MRLPKAKGQD VLHLDFLLTY KPQQQDISNT
     RATREEFDRW YEAIKKEYEL DDTQMTVVMS GLMVWCIENG CSPNISGSWT MMDGDEQTVF
     PLKPVIENAS PTFRQIMHHF SDAAEAYIEY RNSTERYMPR YGLQRNLTDY SLARYAFDFY
     EMNSRTPARA KEAHMQMKAA AVRGSNTRLF GLDGNVGETQ ENTERHTAGD VSRNMHSLLG
     VQQHH