ID   POLR_DROME              Reviewed;        1057 AA.
AC   P16423;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM;
DE   AltName: Full=Retrovirus-related Pol polyprotein from type II retrotransposable element R2DM;
DE   Includes:
DE     RecName: Full=Protease;
DE              EC=3.4.23.-;
DE   Includes:
DE     RecName: Full=Reverse transcriptase;
DE              EC=2.7.7.49;
DE   Includes:
DE     RecName: Full=Endonuclease;
GN   Name=pol;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Oregon-R;
RX   PubMed=1690812; DOI=10.1016/0022-2836(90)90303-4;
RA   Jakubczak J.L., Xiong Y., Eickbush T.H.;
RT   "Type I (R1) and type II (R2) ribosomal DNA insertions of Drosophila
RT   melanogaster are retrotransposable elements closely related to those of
RT   Bombyx mori.";
RL   J. Mol. Biol. 212:37-52(1990).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.49; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU00405};
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DR   EMBL; X51967; CAA36225.1; -; Genomic_DNA.
DR   PIR; S09112; S09112.
DR   AlphaFoldDB; P16423; -.
DR   PRIDE; P16423; -.
DR   FlyBase; FBgn0016699; R2-element\ORF.
DR   PRO; PR:P16423; -.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00078; RVT_1; 1.
DR   SMART; SM00355; ZnF_C2H2; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS50878; RT_POL; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   4: Predicted;
KW   Aspartyl protease; Endonuclease; Hydrolase; Metal-binding; Nuclease;
KW   Nucleotidyltransferase; Protease; RNA-directed DNA polymerase; Transferase;
KW   Transposable element; Zinc; Zinc-finger.
FT   CHAIN           1..1057
FT                   /note="Retrovirus-related Pol polyprotein from type-2
FT                   retrotransposable element R2DM"
FT                   /id="PRO_0000058511"
FT   DOMAIN          384..660
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00405"
FT   ZN_FING         61..84
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          173..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1057 AA;  120041 MW;  64989B5E215CD2AF CRC64;
     FERKNFSDGL VPQRKFIHIG TTSTNNEPRI PLHNLMTTRP SVDIFPEDQY EPNAAATLSR
     VPCTVCGRSF NSKRGLGVHM RSRHPDELDE ERRRVDIKAR WSDEEKWMMA RKEVELTANG
     CKHINKQLAV YFANRSVEAI KKLRQRGDYK EKIEQIRGQS ALAPEVANLT IRRRPSRSEQ
     DHQVTTSETT PITPFEQSNR EILRTLRGYS PVECHSKWRA QELQTIIDRA HLEGKETTLQ
     CLSLYLLGIF PAQGVRHTLT RPPRRPRNRR ESRRQQYAVV QRNWDKHKGR CIKSLLNGTD
     ESVMPSQEIM VPYWREVMTQ PSPSSCSGEV IQMDHSLERV WSAITEQDLR ASRVSLSSSP
     GPDGITPKSA REVPSGIMLR IMNLILWCGN LPHSIRLART VFIPKTVTAK RPQDFRPISV
     PSVLVRQLNA ILATRLNSSI NWDPRQRGFL PTDGCADNAT IVDLVLRHSH KHFRSCYIAN
     LDVSKAFDSL SHASIYDTLR AYGAPKGFVD YVQNTYEGGG TSLNGDGWSS EEFVPARGVK
     QGDPLSPILF NLVMDRLLRT LPSEIGAKVG NAITNAAAFA DDLVLFAETR MGLQVLLDKT
     LDFLSIVGLK LNADKCFTVG IKGQPKQKCT VLEAQSFYVG SSEIPSLKRT DEWKYLGINF
     TATGRVRCNP AEDIGPKLQR LTKAPLKPQQ RLFALRTVLI PQLYHKLALG SVAIGVLRKT
     DKLIRYYVRR WLNLPLDVPI AFVHAPPKSG GLGIPSLRWV APMLRLRRLS NIKWPHLTQN
     EVASSFLEAE KQRARDRLLA EQNELLSRPA IEKYWANKLY LSVDGSGLRE GGHYGPQHGW
     VSQPTRLLTG KEYMDGIRLR INALPTKSRT TRGRHELERQ CRAGCDAPET TNHIMQKCYR
     SHGRRVARHN CVVNRIKRGL EERGCVVIVE PSLQCESGLN KPDLVALRQN HIDVIDTQIV
     TDGHSMDDAH QRKINRYDRP DIRTELRRRF EAAGDIEFHS ATLNWRGIWS GQSVKRLIAK
     GLLSKYDSHI ISVQVMRGSL GCFKQFMYLS GFSRDWT