ID   A9_VACCA                Reviewed;          94 AA.
AC   O57222;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   23-FEB-2022, entry version 52.
DE   RecName: Full=Virion membrane protein A9;
DE   Flags: Precursor;
GN   OrderedLocusNames=MVA120L, ACAM3000_MVA_120; ORFNames=A9L;
OS   Vaccinia virus (strain Ankara) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=126794;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9601507; DOI=10.1006/viro.1998.9123;
RA   Antoine G., Scheiflinger F., Dorner F., Falkner F.G.;
RT   "The complete genomic sequence of the modified vaccinia Ankara strain:
RT   comparison with other orthopoxviruses.";
RL   Virology 244:365-396(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Acambis 3000;
RA   Esposito J.J., Frace M., Sammons S.A., Olsen-Rasmussen M.S., Osborne J.,
RA   Khristova M., Wohlhueter R.M.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Envelope protein. Required for an early step in virion
CC       morphogenesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}. Host cytoplasm {ECO:0000250}.
CC       Note=Component of the mature virion (MV) membrane. The mature virion is
CC       located in the cytoplasm of infected cells and is probably released by
CC       cell lysis. Also found in cytoplasmic virus factories (By similarity).
CC       {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A9 family. {ECO:0000305}.
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DR   EMBL; U94848; AAB96461.1; -; Genomic_DNA.
DR   EMBL; AY603355; AAT10518.1; -; Genomic_DNA.
DR   PIR; T37396; T37396.
DR   SMR; O57222; -.
DR   Proteomes; UP000159908; Genome.
DR   Proteomes; UP000172909; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006920; Poxvirus_A9.
DR   Pfam; PF04835; Pox_A9; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Host cytoplasm; Late protein; Membrane; Signal;
KW   Transmembrane; Transmembrane helix; Viral envelope protein; Virion.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..94
FT                   /note="Virion membrane protein A9"
FT                   /id="PRO_0000099225"
FT   TOPO_DOM        23..45
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        67..83
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   REGION          74..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        83
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   94 AA;  10647 MW;  F3C947A91DA96DDB CRC64;
     MSCYTAILKS VGGLALFQVA NGAIDLCRHF FMYFCEQKLR PNSFWFVVVR AIASMIMYLV
     LGIALLYISE QDNKKNTNND KRNESSINSN SSPK