AT5L2_HUMAN
ID AT5L2_HUMAN Reviewed; 100 AA.
AC Q7Z4Y8;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Putative ATP synthase subunit g 2, mitochondrial {ECO:0000305};
DE Short=ATPase subunit g 2;
DE AltName: Full=ATP synthase membrane subunit g-like protein {ECO:0000305};
GN Name=ATP5MGL {ECO:0000312|HGNC:HGNC:13213}; Synonyms=ATP5K2, ATP5L2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Lin W., Yu L., Zhou Y., Zhang M., Wang X.K., Zhao S.Y.;
RT "Cloning of a novel human cDNA homology to cattle heart F1Fo-ATP synthase
RT complex Fo membrane domain g subunit mRNA.";
RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC Complex V) produces ATP from ADP in the presence of a proton gradient
CC across the membrane which is generated by electron transport complexes
CC of the respiratory chain. F-type ATPases consist of two structural
CC domains, F(1) - containing the extramembraneous catalytic core, and
CC F(0) - containing the membrane proton channel, linked together by a
CC central stalk and a peripheral stalk. During catalysis, ATP synthesis
CC in the catalytic domain of F(1) is coupled via a rotary mechanism of
CC the central stalk subunits to proton translocation. Part of the complex
CC F(0) domain. Minor subunit located with subunit a in the membrane (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC - and CF(0) - the membrane proton channel. CF(0) seems to have nine
CC subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L).
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ATPase g subunit family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AF092923; AAP97217.1; -; mRNA.
DR EMBL; BC093719; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC093721; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS54534.1; -.
DR RefSeq; NP_001159349.1; NM_001165877.1.
DR AlphaFoldDB; Q7Z4Y8; -.
DR SMR; Q7Z4Y8; -.
DR BioGRID; 129369; 4.
DR ComplexPortal; CPX-6151; Mitochondrial proton-transporting ATP synthase complex.
DR STRING; 9606.ENSP00000421076; -.
DR iPTMnet; Q7Z4Y8; -.
DR PhosphoSitePlus; Q7Z4Y8; -.
DR BioMuta; ATP5L2; -.
DR DMDM; 74762435; -.
DR jPOST; Q7Z4Y8; -.
DR MassIVE; Q7Z4Y8; -.
DR MaxQB; Q7Z4Y8; -.
DR PaxDb; Q7Z4Y8; -.
DR PeptideAtlas; Q7Z4Y8; -.
DR PRIDE; Q7Z4Y8; -.
DR ProteomicsDB; 69254; -.
DR Antibodypedia; 57396; 109 antibodies from 20 providers.
DR DNASU; 267020; -.
DR Ensembl; ENST00000505920.1; ENSP00000421076.1; ENSG00000249222.1.
DR GeneID; 267020; -.
DR KEGG; hsa:267020; -.
DR MANE-Select; ENST00000505920.1; ENSP00000421076.1; NM_001165877.1; NP_001159349.1.
DR UCSC; uc003bda.1; human.
DR CTD; 267020; -.
DR DisGeNET; 267020; -.
DR GeneCards; ATP5MGL; -.
DR HGNC; HGNC:13213; ATP5MGL.
DR HPA; ENSG00000249222; Tissue enhanced (bone marrow, brain).
DR MalaCards; ATP5MGL; -.
DR neXtProt; NX_Q7Z4Y8; -.
DR OpenTargets; ENSG00000249222; -.
DR PharmGKB; PA134948694; -.
DR VEuPathDB; HostDB:ENSG00000249222; -.
DR eggNOG; KOG4103; Eukaryota.
DR GeneTree; ENSGT00390000009724; -.
DR HOGENOM; CLU_152793_1_1_1; -.
DR InParanoid; Q7Z4Y8; -.
DR OMA; EVSTWFY; -.
DR OrthoDB; 1461139at2759; -.
DR PhylomeDB; Q7Z4Y8; -.
DR TreeFam; TF313978; -.
DR PathwayCommons; Q7Z4Y8; -.
DR BioGRID-ORCS; 267020; 124 hits in 1004 CRISPR screens.
DR GenomeRNAi; 267020; -.
DR Pharos; Q7Z4Y8; Tdark.
DR PRO; PR:Q7Z4Y8; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q7Z4Y8; protein.
DR Bgee; ENSG00000249222; Expressed in adrenal tissue and 21 other tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IC:ComplexPortal.
DR GO; GO:0005753; C:mitochondrial proton-transporting ATP synthase complex; IC:ComplexPortal.
DR GO; GO:0000276; C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015986; P:proton motive force-driven ATP synthesis; IBA:GO_Central.
DR InterPro; IPR006808; ATP_synth_F0_gsu_mt.
DR InterPro; IPR016702; ATP_synth_su_G_mt_met.
DR PANTHER; PTHR12386; PTHR12386; 1.
DR Pfam; PF04718; ATP-synt_G; 1.
DR PIRSF; PIRSF017835; ATP-synth_g_mitoch_animal; 1.
PE 5: Uncertain;
KW ATP synthesis; CF(0); Hydrogen ion transport; Ion transport; Membrane;
KW Mitochondrion; Reference proteome; Transport.
FT CHAIN 1..100
FT /note="Putative ATP synthase subunit g 2, mitochondrial"
FT /id="PRO_0000225013"
SQ SEQUENCE 100 AA; 11037 MW; 660C6E40987172D6 CRC64;
MAPFVRNLVE KTPALVNAAV TYLKPRLAAF WYYTTVELVP PTPAEIPRAI QSLKKIVSSA
QTGSFKQLTV KEALLNGLVA TEVSTWFYVR EITGKRGIIG
