AT7L1_MOUSE
ID AT7L1_MOUSE Reviewed; 146 AA.
AC Q9CZ05; Q8VD60;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Ataxin-7-like protein 1;
DE AltName: Full=Ataxin-7-like protein 4;
GN Name=Atxn7l1; Synonyms=Atxn7l4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-146 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 28-146 (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CZ05-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CZ05-2; Sequence=VSP_021186;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH17546.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB28677.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC132312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC132354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK013145; BAB28677.1; ALT_INIT; mRNA.
DR EMBL; BC017546; AAH17546.1; ALT_INIT; mRNA.
DR CCDS; CCDS25874.2; -. [Q9CZ05-1]
DR RefSeq; NP_082415.2; NM_028139.5. [Q9CZ05-1]
DR AlphaFoldDB; Q9CZ05; -.
DR IntAct; Q9CZ05; 2.
DR MINT; Q9CZ05; -.
DR iPTMnet; Q9CZ05; -.
DR PhosphoSitePlus; Q9CZ05; -.
DR PRIDE; Q9CZ05; -.
DR ProteomicsDB; 265171; -. [Q9CZ05-1]
DR ProteomicsDB; 265172; -. [Q9CZ05-2]
DR Antibodypedia; 17103; 235 antibodies from 23 providers.
DR DNASU; 380753; -.
DR Ensembl; ENSMUST00000077456; ENSMUSP00000076668; ENSMUSG00000020564. [Q9CZ05-2]
DR Ensembl; ENSMUST00000110824; ENSMUSP00000106448; ENSMUSG00000020564. [Q9CZ05-1]
DR GeneID; 380753; -.
DR KEGG; mmu:380753; -.
DR UCSC; uc007nin.2; mouse. [Q9CZ05-1]
DR UCSC; uc007nio.2; mouse. [Q9CZ05-2]
DR CTD; 222255; -.
DR MGI; MGI:3584458; Atxn7l1.
DR VEuPathDB; HostDB:ENSMUSG00000020564; -.
DR GeneTree; ENSGT00940000158612; -.
DR HOGENOM; CLU_148763_0_0_1; -.
DR InParanoid; Q9CZ05; -.
DR OrthoDB; 693000at2759; -.
DR BioGRID-ORCS; 380753; 4 hits in 38 CRISPR screens.
DR ChiTaRS; Atxn7l1; mouse.
DR PRO; PR:Q9CZ05; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q9CZ05; protein.
DR Bgee; ENSMUSG00000020564; Expressed in granulocyte and 210 other tissues.
DR ExpressionAtlas; Q9CZ05; baseline and differential.
DR Genevisible; Q9CZ05; MM.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..146
FT /note="Ataxin-7-like protein 1"
FT /id="PRO_0000254144"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 62..84
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021186"
SQ SEQUENCE 146 AA; 16186 MW; 19DA9F91E6CF8CF1 CRC64;
MTSERSRIPC LSAAAAEGTG KKQQEGTAMA TLHRKVPSPE AFLGKPWSSW IDAAKLHCSD
NVDLEEAGKE GGKSREVMRL NKEDMHLFGH YPAHDDFYLV VCSACNQVVK PQVFQSHCGR
KQDSKRNASI SWSGAESRQA LEQRQV
