ID   POL_RSFFV               Reviewed;         116 AA.
AC   P03358;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   02-DEC-2020, entry version 56.
DE   RecName: Full=Pol polyprotein;
DE   Contains:
DE     RecName: Full=Integrase;
DE              Short=IN;
DE              EC=2.7.7.- {ECO:0000305};
DE              EC=3.1.-.- {ECO:0000305};
DE   Flags: Fragment;
GN   Name=pol;
OS   Rauscher spleen focus-forming virus (RSFFV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Gammaretrovirus;
OC   unclassified Gammaretrovirus.
OX   NCBI_TaxID=11821;
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=6088793; DOI=10.1128/jvi.51.3.695-705.1984;
RA   Bestwick R.K., Boswell B.A., Kabat D.;
RT   "Molecular cloning of biologically active Rauscher spleen focus-forming
RT   virus and the sequences of its env gene and long terminal repeat.";
RL   J. Virol. 51:695-705(1984).
CC   -!- FUNCTION: [Integrase]: Catalyzes viral DNA integration into the host
CC       chromosome, by performing a series of DNA cutting and joining
CC       reactions. {ECO:0000305}.
CC   -!- MISCELLANEOUS: The Rauscher and Friend erythroleukemia viruses contain
CC       two components. The spleen focus-forming virus (SFFV) is replication
CC       defective, and causes foci of proliferating erythroid cells in spleens
CC       of infected mice. The second component is a replication competent
CC       murine leukemia virus (MuLV) that serves as a helper virus for SFFV.
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DR   EMBL; K02375; AAA46504.1; -; Genomic_RNA.
DR   PIR; A05070; A05070.
DR   SMR; P03358; -.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR   InterPro; IPR040643; MLVIN_C.
DR   Pfam; PF18697; MLVIN_C; 1.
PE   4: Predicted;
KW   DNA integration; Endonuclease; Hydrolase; Nuclease; Nucleotidyltransferase;
KW   Transferase; Viral genome integration; Virus entry into host cell.
FT   CHAIN           <1..116
FT                   /note="Integrase"
FT                   /id="PRO_0000442866"
FT   CHAIN           <1..116
FT                   /note="Pol polyprotein"
FT                   /id="PRO_0000125495"
FT   NON_TER         1
SQ   SEQUENCE   116 AA;  13029 MW;  510B26496C9C2155 CRC64;
     AHLHALYLVH HEVWRPLAAA YQHQLDRPIV PHPFRLGDTV WVRRHQTNNL QPRWKAPYTV
     LLTTPTALKV DGIAAWIHAA HVKAATTPPA GTASGPTWKV QRSQNPLKIR LTRGAP