ID   A9_VACCC                Reviewed;          99 AA.
AC   P20987;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   23-FEB-2022, entry version 60.
DE   RecName: Full=Virion membrane protein A9;
DE   Flags: Precursor;
GN   ORFNames=A9L;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Envelope protein. Required for an early step in virion
CC       morphogenesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}. Host cytoplasm {ECO:0000250}.
CC       Note=Component of the mature virion (MV) membrane. The mature virion is
CC       located in the cytoplasm of infected cells and is probably released by
CC       cell lysis. Also found in cytoplasmic virus factories (By similarity).
CC       {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A9 family. {ECO:0000305}.
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DR   EMBL; M35027; AAA48128.1; -; Genomic_DNA.
DR   PIR; B42518; B42518.
DR   SMR; P20987; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006920; Poxvirus_A9.
DR   Pfam; PF04835; Pox_A9; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Host cytoplasm; Late protein; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix; Viral envelope protein; Virion.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..99
FT                   /note="Virion membrane protein A9"
FT                   /id="PRO_0000099226"
FT   TOPO_DOM        23..45
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        67..83
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   REGION          73..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..99
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        88
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   99 AA;  11136 MW;  850D856D133C30F0 CRC64;
     MSCYTAILKS VGGLALFQVA NGAIDLCRHF FMYFCEQKLR PNSFWFVVVR AIASMIMYLV
     LGIALLYISE QDDKKNTNND GSNNDKRNES SINSNSSPK